Category: 1692-25-7

In 2019,Talanta included an article by Xu, Shaomei; Che, Songtian; Ma, Pinyi; Zhang, Fangmei; Xu, Longbin; Liu, Xin; Wang, Xinghua; Song, Daqian; Sun, Ying. Application of 1692-25-7. The article was titled 《One-step fabrication of boronic-acid-functionalized carbon dots for the detection of sialic acid》. The information in the text is summarized as follows:

Typically, sialic acids (SA) with a nine-carbon backbone are found at the glycan chain termini on the cell membranes, which play crucial roles in various physiol. and pathol. processes. The expression level of SA in the blood serum has been reported to correlate with various disease states among cancer. A novel approach for preparing fluorescent boronic-acid-modified carbon dots (C-dots) for the detection of SA was developed. The functionalized C-dots were synthesized by a facile, one-step hydrothermal method using 3-pyridineboronic acid as the sole carbon source. The added SA selectively recognized the C-dots, leading to the fluorescence quenching of the C-dots in a linear range of 80-4000 μM with a detection limit of 54 μM. The as-developed boronic-acid nanoprobe was successfully applied for the detection of SA in human serum samples with satisfactory results. In addition, this method afforded results within 4 min. Compared to other methods, this new proposed approach was simpler and exhibited excellent sensitivity and selectivity, demonstrating immense potential as an alternative for SA detection. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Application of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Phenyldihydropyrazolones as Novel Lead Compounds Against Trypanosoma cruzi》 were Sijm, Maarten; Siciliano de Araujo, Julianna; Kunz, Stefan; Schroeder, Susanne; Edink, Ewald; Orrling, Kristina M.; Matheeussen, An; van de Meer, Tiffany; Sadek, Payman; Custers, Hans; Cotillo, Ignacio; Martin, Julio J.; Siderius, Marco; Maes, Louis; Brown, David G.; de Nazare Correia Soeiro, Maria; Sterk, GeertJan; de Esch, Iwan J. P.; Leurs, Rob. And the article was published in ACS Omega in 2019. HPLC of Formula: 1692-25-7 The author mentioned the following in the article:

As over 6 million people are infected with Chagas disease and only limited therapeutic options are available, there is an urgent need for novel drugs. The involvement of cyclic nucleotide phosphodiesterases (PDE) in the life cycle and biol. fitness of a number of protozoan parasites has been described and several of these enzymes are thought to be viable drug targets. Within this context, a PDE-focused library was screened for its ability to affect the viability of Trypanosoma cruzi parasites. Previously reported human PDE4 inhibitor, 5-(3-(benzyloxy)-4-methoxyphenyl)-2-isopropyl-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one, was identified as a hit. Upon optimization on three positions of the phenylpyrazolone scaffold, 2-isopropyl-5-(4-methoxy-3-(pyridin-3-yl)phenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (I) proved to be the most active compound against intracellular forms of T. cruzi (pIC50 = 6.4) with a 100-fold selectivity with respect to toxicity towards human MRC-5 cells. Evaluation on different life stages and clin. relevant T. cruzi strains revealed that the phenylpyrazolones are not active against the bloodstream form of the Y strain but show submicromolar activity against the intracellular form of the Y- and Tulahuen strains as well as against the nitro-drug resistant Colombiana strain. In vitro screening of phenylpyrazolones against TcrPDEB1, TcrPDEC and TcrCYP51 showed that there was a poor correlation between enzyme inhibition and the observed phenotypic effect. Amongst the most potent compounds both TcrCYP51 and non-TcrCYP51 inhibitors are identified, which were both equally able to inhibit T. cruzi in vitro. In addition to this study using Pyridin-3-ylboronic acid, there are many other studies that have used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H6BNO2In 2022 ,《Merging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening》 was published in ACS Catalysis. The article was written by Li, Shasha; Pissarnitski, Dmitri; Nowak, Timothy; Wleklinski, Michael; Krska, Shane W.. The article contains the following contents:

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki-Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chem. diversification method by synthesizing a multidimensional library of diverse peptides in high yields. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and biological evaluation of analogs of didehydroepiandrosterone as potential new anticancer agents》 was written by Solum, Eirik J.; Liekens, Sandra; Hansen, Trond Vidar. Related Products of 1692-25-7 And the article was included in Molecules in 2020. The article conveys some information:

The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs I (Ar = C6H5, isoquinolin-5-yl, indole-5-yl, etc.) of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are the most promising anti-proliferative agents. These compounds exhibited potent cytotoxic effects in CEM, HeLa and HMEC-1 cells. All three compounds exhibited IC50 values < 10μM. The analog I (Ar = indole-5-yl) exhibited an IC50 value of 0.59μM towards the human dermal microvascular endothelial cell line (HMEC-1), significantly lower than the reference standard 2-methoxyestradiol. At a concentration at 50 nM the most potent I (Ar = isoquinolin-5-y) compound reduced the activity of CDK8 to 35%. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Qiu, Jian; Wang, Cece; Zhou, Lu; Lou, Yixian; Yang, Kai; Song, Qiuling published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Radical-Promoted Defluoroalkylborylation of Trifluoromethyl Alkenes To Access gem-Difluorohomoallylic Boronates》.Safety of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Gem-Difluoroalkenyl boronates are attractive synthons for constructing diverse gem-difluoroalkenes and organoboron compounds However, the strategies for the construction of gem-difluorohomoallyl boronates has scarcely been described. Herein, authors develop an efficient protocol for the construction of gem-difluorohomoallylic boronates through a Ni-catalyzed radical-promoted defluoroalkylborylation of α-trifluoromethyl alkenes with α-haloboronates under mild conditions. This reaction features a broad substrate scope with good functional group tolerance and diverse transformations. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Pyridin-3-ylboronic acidIn 2020 ,《Sequential C-S and S-N Coupling Approach to Sulfonamides》 was published in Organic Letters. The article was written by Chen, Kai; Chen, Wei; Han, Bing; Chen, Wanzhi; Liu, Miaochang; Wu, Huayue. The article contains the following contents:

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides RNHS(O)2R1 [R = Ph, 3-pyridyl, 1-naphthyl, etc.; R1 = Ph, 2-thienyl, 2-naphthyl, etc.] was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Di, Jia-Qi; Zhang, Mo; Chen, Yu-Xuan; Wang, Jin-Xin; Geng, Shan-Shan; Tang, Jia-Qi; Zhang, Zhan-Hui published their research in Green Chemistry in 2021. The article was titled 《Copper anchored on phosphorus g-C3N4 as a highly efficient photocatalyst for the synthesis of N-arylpyridin-2-amines》.Safety of Pyridin-3-ylboronic acid The article contains the following contents:

A heterogeneous photocatalyst based on copper modified phosphorus doped g-C3N4 (Cu/P-CN) has been prepared and characterized. This recyclable catalyst exhibited high photocatalytic activity for the synthesis of N-arylpyridin-2-amine derivatives I (Ar = Ph, naphthalen-1-yl, thiophen-3-yl, dibenzo[b,d]furan-3-yl, etc.; R = H, Me; R1 = H, Cl, Br, Me, NO2; R2 = H, Cl, Br, Me; R3 = H, Cl, Br) by the reaction of 2-aminopyridines II and aryl boronic acids ArB(OH)2 at room temperature under the irradiation of blue light. Importantly, the range of substrates for this coupling reaction has been expanded to include aryl boronic acids with strong electron-withdrawing groups as viable raw materials. In addition, this heterogeneous catalyst can be used at least 6 times while maintaining its catalytic activity. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bollenbach, Maud; Nemska, Simona; Wagner, Patrick; Camelin, Guillaume; Daubeuf, Francois; Obrecht, Adeline; Villa, Pascal; Rognan, Didier; Bihel, Frederic; Bourguignon, Jean-Jacques; Schmitt, Martine; Frossard, Nelly published their research in Molecules in 2021. The article was titled 《Design, synthesis and biological evaluation of arylpyridin-2-yl guanidine derivatives and cyclic mimetics as novel MSK1 inhibitors. An application in an asthma model》.Electric Literature of C5H6BNO2 The article contains the following contents:

In order to identify new MSK1 inhibitors, a screening of a library of low mol. weight compounds was performed, and the results highlighted the I [R = phenyl] ( IC50~18μM) as a starting hit for structure-activity relationship study. Derivatives, homologues and rigid mimetics of I [R = Ph, 2-furanyl, 3-pyridine, etc.] were designed, and all synthesized compounds were evaluated for their inhibitory activity towards MSK1. Among them, the non-cytotoxic 2-aminobenzimidazole was the most potent at inhibiting significantly: (i) MSK1 activity, (ii) the release of IL-6 in inflammatory conditions in vitro (IC50~2μM) and (iii) the inflammatory cell recruitment to the airways in a mouse model of asthma. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synergistic Enhancement Effects of Carbon Quantum Dots and Au Nanoclusters for Cathodic ECL and Non-enzyme Detections of Glucose》 was written by Han, Shuang; Gao, Yuan; Li, Lin; Lu, Beibei; Zou, Yongxing; Zhang, Ling; Zhang, Jiaheng. Quality Control of Pyridin-3-ylboronic acid And the article was included in Electroanalysis in 2020. The article conveys some information:

In this study, we found that glucose enhance electrochemiluminescence (ECL) intensity of both Au nanoclusters (Au NCs) and carbon quantum dots (CQDs) with K2S2O8 as the co-reactants. The enhancing effects by Au NCs and CQDs were overlapped, enabling the detection of glucose. The increased ECL intensity of glucose was linear with the logarithm of concentrations of glucose in the range of 50μM-3.0 mM, and the limit of detection is 20μM. Anti-interruption ability was achieved, and ascorbic acid, urea, and uric acid had little influence to glucose detection. This method realized the direct detection of glucose by enhancing ECL of Au NCs and CQDs, which was fast and economic, possessing potential applications for glucose detection in human serum. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H6BNO2In 2022 ,《A Pyridine-based Donor-Acceptor Molecule: A Highly Reactive Organophotocatalyst that Enables the Reductive Cleavage of C-Br Bonds through Halogen Bonding》 appeared in ACS Catalysis. The author of the article were Kato, Natsuki; Nanjo, Takeshi; Takemoto, Yoshiji. The article conveys some information:

A pyridine-based donor-acceptor mol. that exhibited high reactivity as a visible-light photoredox catalyst. This photoredox catalyst enabled the formation of radicals from alkyl bromides, which were useful radical precursors that unfortunately do not perform well under reductive conditions, by a direct, photocatalytic reductive cleavage of the C-Br bond. A wide variety of alkyl bromides including unactivated ones could be used under ambient conditions without any addnl. activating agents to give the C-C coupling products in good yield. Mechanistic studies indicated that the photocatalyst interacts with alkyl bromides through halogen bonding and that the pyridine moiety was important for the progress of the reaction. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Synthetic Route of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem