Category: 1692-25-7

Cao, Liang; Zhao, He; Guan, Rongqing; Jiang, Huanfeng; Dixneuf, Pierre. H.; Zhang, Min published an article in 2021. The article was titled 《Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution》, and you may find the article in Nature Communications.SDS of cas: 1692-25-7 The information in the text is summarized as follows:

Despite the widespread applications of 2-(hetero)aryl N-heteroarenes in numerous fields of science and technol., universal access to such compounds is hampered due to the lack of a general method for their synthesis. Herein, by a H2O-mediated H2-evolution cross-coupling strategy, an iridium(III)-catalyzed facile method to direct α-arylation of N-heteroarenes with both aryl and heteroaryl boronic acids, proceeding with broad substrate scope and excellent functional compatibility, oxidant and reductant-free conditions, operational simplicity, easy scalability, and no need for prefunctionalization of N-heteroarenes is reported. This method is applicable for structural modification of biomedical mols., and offers a practical route for direct access to 2-(hetero)aryl N-heteroarenes, a class of potential cyclometalated CN̂ ligands and NN̂ bidentate ligands that are difficult to prepare with the existing α-C-H arylation methods, thus filling an important gap in the capabilities of synthetic organic chem. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7SDS of cas: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.SDS of cas: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reason, Thomas E.; Goka, Benjamin; Krause, Jeanette A.; Fionah, Abelline K.; Zahran, Elsayed M.; Rayat, Sundeep published their research in CrystEngComm in 2021. The article was titled 《Cu2O nanoparticle-catalyzed synthesis of diaryl tetrazolones and investigation of their solid-state properties》.Synthetic Route of C5H6BNO2 The article contains the following contents:

An efficient and versatile method for the synthesis of 1,4-diaryl tetrazolones I [Ar1 = Ph, 4-MeOC6H4, 4-O2NC6H4; Ar2 = Ph, 4-FC6H4, 3-pyridyl, etc.] was reported which involved C-N coupling of aryl tetrazolones with aryl boronic acids in the presence of Cu2O nanoparticles under an oxygen atm. and DMSO as solvent. The reaction tolerated a variety of electron donating and electron withdrawing substituents on both substrates and produced the desired 1,4-diaryl tetrazolones I in moderate to good yields. In the crystal lattice, the mols. exhibited π···π stacking interactions between the adjacent layers as well as weak through-space electrostatic C-H···O interactions involved the pendant rings and tetrazolone carbonyl. The compounds I [Ar1 = 4-MeOC6H4; Ar2 = 3-MeC6H4, 3-FC6H4] differed only in the presence of one group (Me or fluoro), exhibited an identical pattern of noncovalent interactions in the solid-state. Hirshfeld surface anal. had also been performed to visualize intermol. interactions. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones》 was published in Organic Letters in 2020. These research results belong to Guo, Yuan-Qiang; Wang, Ruiguo; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. Electric Literature of C5H6BNO2 The article mentions the following:

Herein, we describe an efficient, practical photocatalytic deoxygenation/defluorination protocol for the synthesis of γ,γ-difluoroallylic ketones from com. available aromatic carboxylic acids, triphenylphosphine, and α-trifluoromethyl alkenes. The protocol has good functional group tolerance and a broad substrate scope. Using this method, we accomplished the late-stage functionalization of several bioactive mols. The experimental part of the paper was very detailed, including the reaction process of Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Siddiqa, Ayesha; Zubair, Muhammad; Bilal, Muhammad; Rasool, Nasir; Qamar, Muhammad Usman; Khalid, Aqsa; Ahmad, Gulraiz; Imran, Muhammad; Mahmood, Sajid; Ashraf, Ghulam Abbas published an article in Pharmaceuticals. The title of the article was 《Synthesis of Functionalized N-(4-Bromophenyl)furan-2-carboxamides via Suzuki-Miyaura Cross-Coupling: Anti-Bacterial Activities against Clinically Isolated Drug Resistant A. baumannii, K. pneumoniae, E. cloacae and MRSA and Its Validation via a Computational Approach》.HPLC of Formula: 1692-25-7 The author mentioned the following in the article:

N-(4-Bromophenyl)furan-2-carboxamide I [R = Br] was synthesized by the reaction furan-2-carbonyl chloride and 4-bromoaniline in the presence of Et3N in excellent yields of 94%. The carboxamide I [R = Br] was arylated by employing triphenylphosphine palladium as a catalyst and K3PO4 as a base to afford N-(4-bromophenyl)furan-2-carboxamide analogs I [R = 4-MeC6H4, 4-MeOC6H4, 4-ClC6H4, etc.] in moderate to good yields (43-83%). Furthermore, in vitro anti-bacterial activities of the resp. compounds against clin. isolated drug-resistant bacteria A. baumannii, K. pneumoniae, E. cloacae and S. aureus was investigated. The mol. I [R = Br] was found to be the most effective activity against these bacteria, particularly NDM-pos. bacteria A. baumannii as compared to various com. available drugs. Docking studies and MD simulations further validated it, expressing the active site and mol. interaction stability. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H6BNO2In 2022 ,《Solvent and Counteranion Assisted Dynamic Self-Assembly of Molecular Triangles and Tetrahedral Cages》 was published in Inorganic Chemistry. The article was written by Kumar, Atul; Banerjee, Ranit; Zangrando, Ennio; Mukherjee, Partha Sarathi. The article contains the following contents:

Self-assembly of naked PdII ions sep. with newly designed bis(3-pyridyl)benzothiadiazole (L1) and bis(3-pyridyl)thiazolo[5,4-d]thiazole (L2) donors sep., under varying exptl. conditions, yielded Pd4L8 (L = L1 or L2) tetrahedral cages and their homologous Pd3L6 (L = L1 or L2) double-walled triangular macrocycles. The resulting assemblies exhibited solvent, temperature, and counteranion induced dynamic equilibrium Treatment of L1 with Pd(BF4)2 in acetonitrile (ACN) resulted in selective formation of a tetrahedral cage [Pd4(L1)8](BF4)8 (1a), which is in dynamic equilibrium with its homolog triangle [Pd3(L1)6](BF4)6 (2a) in DMSO. However, similar self-assembly using L2 instead of L1 yielded an equilibrium mixture of tetrahedral cage [Pd4(L2)8](BF4)8 (3a) and triangle [Pd3(L2)6](BF4)6 (4a) forms in both ACN and DMSO. The assembles were characterized by multinuclear NMR and ESI-MS while the structure of the tetrahedral cage (1a) was determined by single crystal x-ray diffraction. Existence of a dynamic equilibrium between the assemblies in solution was studied via variable temperature 1H NMR. The equilibrium constant K = ([Pd4L8]3/[Pd3L6]4) was calculated at each exptl. temperature and fitted with the Van’t Hoff equation to determine the standard enthalpy (ΔH°) and entropy (ΔS°) associated with the interconversion of the double-walled triangle to tetrahedral cage. The thermodn. feasibility of structural interconversion was analyzed from the change in ΔG°, which suggests favorable conversion of Pd3L6 triangle to Pd4L8 cage at elevated temperature for L1 in DMSO and L2 in ACN. Similar self-assembly reactions of L1 and L2 with Pd(NO3)2 instead of Pd(BF4)2 resulted in selective formation of a tetrahedral cage [Pd4(L1)8](NO3)8 (1b) and double-walled triangle [Pd3(L2)6](NO3)6 (4b), resp. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Molecular design and structural pecularities of the 3- and 4-pyridylboron-capped tris-glyoximate and tris-dichloroglyoximate iron(II) clathrochelates with apical donor groups》 were Zelinskii, Genrikh E.; Belov, Alexander S.; Vologzhanina, Anna V.; Limarev, Ilya P.; Dorovatovskii, Pavel V.; Zubavichus, Yan V.; Lebed, Ekaterina G.; Voloshin, Yan Z.; Dedov, Alexey G.. And the article was published in Polyhedron in 2019. Reference of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Tris-glyoximate and tris-dichloroglyoximate iron(II) clathrochelates with apical pyridyl groups were obtained through one-pot template condensation of the corresponding α-dioxime with 3- or 4-pyridylboronic acids on the iron(II) ion as a matrix under vigorous reaction conditions using the boiling CF3COOH as a solvent. The initially formed mixtures of mono- and diprotonated clathrochelate species were converted into the target macrobicyclic intracomplexes under basic conditions. These complexes were characterized using elemental anal., MALDI-TOF mass spectrometry, IR, UV-visible, 1H and 13C NMR spectroscopies, and by single crystal x-ray diffraction as well. In their mols., the encapsulated iron(II) ion is situated in the center of its FeN6-coordination polyhedron. The geometry of all the FeN6-coordination polyhedra is intermediate between a trigonal prism and a trigonal antiprism with the average distortion angles φ from 16.7 to 17.7°. Their heights h fall from 2.36 to 2.38 Å and the averaged bite angles α vary in a narrow range 78.2-78.4°. Characteristic feature of the 3- and 4-pyridylboron-capped glyoximate clathrochelate mols., as compared with their aliphatic and aromatic analogs, is shortening of the chelate C-C bonds from 1.45 to 1.42 Å. Comparison of the values of a ligand aspect ratio for the obtained new pyridyl-terminated iron(II) clathrochelates with those for their known aliphatic tris-dioximate analogs was performed. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cao, Liang; Zhao, He; Guan, Rongqing; Jiang, Huanfeng; Dixneuf, Pierre. H.; Zhang, Min published an article in 2021. The article was titled 《Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution》, and you may find the article in Nature Communications.SDS of cas: 1692-25-7 The information in the text is summarized as follows:

Despite the widespread applications of 2-(hetero)aryl N-heteroarenes in numerous fields of science and technol., universal access to such compounds is hampered due to the lack of a general method for their synthesis. Herein, by a H2O-mediated H2-evolution cross-coupling strategy, an iridium(III)-catalyzed facile method to direct α-arylation of N-heteroarenes with both aryl and heteroaryl boronic acids, proceeding with broad substrate scope and excellent functional compatibility, oxidant and reductant-free conditions, operational simplicity, easy scalability, and no need for prefunctionalization of N-heteroarenes is reported. This method is applicable for structural modification of biomedical mols., and offers a practical route for direct access to 2-(hetero)aryl N-heteroarenes, a class of potential cyclometalated CN̂ ligands and NN̂ bidentate ligands that are difficult to prepare with the existing α-C-H arylation methods, thus filling an important gap in the capabilities of synthetic organic chem. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7SDS of cas: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.SDS of cas: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discrimination of Pd0 and Pd2+ in solution and in live cells by novel light-up fluorescent probe with AIE and ESIPT characteristics》 was written by Wang, Qiang; Chen, Qingqing; Li, Chunbin; Lai, Qingfang; Zou, Fenglan; Liang, Feng; Jiang, Guoyu; Wang, Jianguo. Related Products of 1692-25-7 And the article was included in Microchemical Journal in 2020. The article conveys some information:

A novel and simple light-up fluorescent probe (PASPy-al) with a D-π-A structure based on AIE as well as ESIPT processes was designed for highly selective discrimination of Pd2+ and Pd0. PASPy-al displayed a large Stokes shift (95 nm), a high light-up ratio (116 fold) and a low limit of detection (LOD: 96 nM) toward Pd0. Moreover, the practical applications of PASPy-al for detection of Pd0 in environmental, human urine and pharmaceutical samples were realized, indicating the unique advantages of designing anti-ACQ fluorescent probes based on AIE and ESIPT mechanism. Fluorescence imaging of Pd0 in live cells was realized by using PASPy-al. Furthermore, imaging of Pd0 generation in live cells was also realized by in situ reduction of Pd2+ to Pd0 in the presence of reducing agent like CO, indicating the potential ability of this probe for further fluorescent imaging of cellular reducing agent. The easy preparation of probe PASPy-al plus their excellent parameters would make it a simple to handle probe for detection of Pd0 both in practical samples and in live cells. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ohtsu, Hiroyoshi; Kim, Joonsik; Kanamaru, Tatsuya; Inoue, Daishi; Hashizume, Daisuke; Kawano, Masaki published an article in 2021. The article was titled 《Stepwise Observation of Iodine Diffusion in a Flexible Coordination Network Having Dual Interactive Sites》, and you may find the article in Inorganic Chemistry.Reference of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

We created dual interactive sites in a porous coordination network using a CuI cluster and a rotation-restricted ligand, tetra(3-pyridyl)phenylmethane (3-TPPM). The dual interactive sites of iodide and Cu ions can adsorb I2 via four-step processes including two chemisorption processes. Initially, one I2 mol. was physisorbed in a pore and successively chemisorbed on iodide sites of the pore surface, and then the next I2 mol. was physisorbed and chemisorbed on Cu ions to form a cross-linked network. We revealed the four-step I2 diffusion process by single-crystal X-ray structure determination and spectroscopic kinetic anal. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Zhewen; Zhao, Jun; Liu, Yuhang; Li, Guangfeng; Wang, Heng; Hou, Yali; Zhang, Mingming; Li, Xiaopeng; Yan, Xuzhou published an article in 2021. The article was titled 《Conformational effect on fluorescence emission of tetraphenylethylene-based metallacycles》, and you may find the article in Chinese Chemical Letters.Application In Synthesis of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

Herein, the authors designed and constructed two metallacycles, 1 and 2, to illustrate the conformational effect of isomeric AIE fluorophores on the platform of supramol. coordination complexes (SCCs). Specifically, the dangling Ph rings in TPE units of the metallacycle 1 align completely outside the main cyclic structure, while in the metallacycle 2, these Ph rings align half inside and half outside. The exptl. results showed that two metallacycles exhibited different behaviors in terms of AIE fluorescence and chem. sensing, which could be attributed to the subtle structural difference of the TPE units. This work represents the unification of topics such as self-assembly, AIE, and chem. sensing, and further promotes the understanding for the structure-property relationship of isomeric AIE fluorophores.Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem