Category: 1692-25-7

Recommanded Product: 1692-25-7In 2022 ,《Design, synthesis and antitumor evaluation of novel quinazoline analogs in hepatocellular carcinoma cell》 appeared in Journal of Molecular Structure. The author of the article were Yu, Pan; Cao, Weiya; Yang, Shilong; Wang, Yuan; Xia, Aixin; Tan, Xinlan; Wang, Luyi. The article conveys some information:

In this paper, five quinazoline analogs I (R = Cl, 1H-indol-5-yl, 4-chlorophenyl, pyridin-3-yl, 4-aminophenyl) were preliminary designed through scaffold shopping from mTOR inhibitors and synthesized in four steps. Five compounds I exhibited potent antitumor activity against the HepG2 cell line by MTT assay. Compound I (R = 1H-indol-5-yl) (II) (IC50 = 4.06μM) was found as the most potent analog and showed better antiproliferative ability than sorafenib (IC50 = 6.14μM). The result of the wound healing assay and transwell migration assay indicated II strong potential to suppress HepG2 cell migration in a dose- and time-dependent manner. The underlying mechanism of its cytotoxicity was also investigated and the results of western blotting confirmed that compound II exposure could block the cell cycle, promote apoptosis and inhibit AKT and mTOR phosphorylation in HepG2 cells. Mol. docking further supported that compound II showed a high affinity to mTOR kinase. The results favored rational design intention and hinted that the new quinazolines I might be helpful in the further explorations of potent agents. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer》 was published in Pharmacological Research in 2020. These research results belong to Zhang, Yu-Hang; Luo, Dong-Dong; Wan, Sheng-Biao; Qu, Xian-Jun. Computed Properties of C5H6BNO2 The article mentions the following:

In this study, S1PR2 was reckoned as a brand-new GPCR target for designing inhibitors to reverse 5-FU resistance. Herein a series of pyrrolidine pyrazoles as the S1PR2 inhibitors were designed, synthesized and evaluated for their activities of anti-FU-resistance. Among them, the most promising compound JTE-013, exhibited excellent inhibition on DPD expression and potent anti-FU-resistance activity in various human cancer cell lines, along with the in vivo HCT116DPD cells xenograft model, in which the inhibition rate of 5-FU was greatly increased from 13.01%-75.87%. The underlying mechanism was uncovered that JTE-013 demonstrated an anti-FU-resistance activity by blocking S1PR2 internalization to the endoplasmic reticulum (ER), which inhibited the degradation of 5-FU into α-fluoro-β-alanine (FBAL) by downregulating tumoral DPD expression. Overall, JTE-013 could serve as the lead compound for the discovery of new anti-FU-resistance drugs. This study provides novel insights that S1PR2 inhibitors could sensitize 5-FU therapy in colorectal cancer. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Computed Properties of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1692-25-7In 2020 ,《General Access to C-Centered Radicals: Combining a Bioinspired Photocatalyst with Boronic Acids in Aqueous Media》 appeared in ACS Catalysis. The author of the article were Chilamari, Maheshwerreddy; Immel, Jacob R.; Bloom, Steven. The article conveys some information:

Carbon-centered radicals are indispensable building blocks for modern synthetic chem. In recent years, visible light photoredox catalysis has become a promising avenue to access C-centered radicals from a broad array of latent functional groups, including boronic acids. Herein, we present an aqueous protocol wherein water features a starring role to help transform aliphatic, aromatic, and heteroaromatic boronic acids to C-centered radicals with a bioinspired flavin photocatalyst. These radicals are used to deliver a diverse pool of alkylated products, including three pharmaceutically relevant compounds, via open-shell conjugate addition to disparate Michael acceptors. The mechanism of the reaction is investigated by computational studies, deuterium labeling, radical-trapping experiments, and spectroscopic anal. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Regioisomeric monopyridine-functionalized triarylethene: small AIEgens with isomeric effect and an efficient platform for the selective and sensitive detection of Pd2+ and Fe3+》 was written by Mukherjee, Atasi; Chakravarty, Manab. Application of 1692-25-7 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

Previously, pyridine-functionalized tetraarylethenes have been established as potential AIEgens (aggregation-induced emission-active fluorogens) for numerous applications, whereas monopyridyl-linked triarylethene has been reported as a non-AIEgen. In this study, we afforded AIE-active monopyridine-functionalized unsym. substituted triarylethene in which naphthyl, biphenyl, and 4-phenylpyridine rotors were attached to an alkene stator. Moreover, two regioisomeric pyridyl compounds were synthesized to study the isomeric effect on AIE properties. Both regioisomeric compounds were found to be AIE-active with slight variation. The reasons behind the AIE properties of these compounds were substantiated by SEM studies, lifetime measurements, and mol. packing studies in a single crystal. The relatively large number of non-covalent interactions in the 4-pyridyl isomer were slightly unfavorable for the emission of fluorescence in the aggregate state; however, these interactions were beneficial for the emission of strong fluorescence in the solid state. Both compounds were individually utilized for the naked eye detection and identification of Fe3+ and Pd2+ based on the extent of fluorescence quenching in the solution state (~10-9 M detection limit) and the solid state (10-3 M for Pd2+ and 10-2 M for Fe3+). The quenching mechanism was found to involve the static and dynamic complexation of pyridyl N-atom with the metal ion. This fact was further proved by 1H NMR titration In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Application of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heydari, Somayyeh; Habibi, Davood; Reza Faraji, Ali; Keypour, Hassan; Mahmoudabadi, Masoumeh published their research in Inorganica Chimica Acta in 2021. The article was titled 《An overview on the progress and development on the palladium catalyzed direct cyanation》.Formula: C5H6BNO2 The article contains the following contents:

The simultaneous use of the new Pd nano-catalyst as well as the three types of the N-arylsulfonyl cyanamides 4-ClC6H4N(CN)S(O)2C6H4(4-X) (X = CH3, Br, NO2) as potent reagents for the in situ generation of the pos. CN ion for the direct cyanation of phenylboronic acids ArB(OH)2 [Ar = 4-ClC6H4, pyridin-3-yl, 2-(dihydroxyboranyl)phenyl, etc.] in acetonitrile at reflux conditions has been described. The experimental part of the paper was very detailed, including the reaction process of Pyridin-3-ylboronic acid(cas: 1692-25-7Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H6BNO2In 2020 ,《Reactivity of Boronic Acids toward Catechols in Aqueous Solution》 appeared in Journal of Organic Chemistry. The author of the article were Suzuki, Yota; Kusuyama, Daisuke; Sugaya, Tomoaki; Iwatsuki, Satoshi; Inamo, Masahiko; Takagi, Hideo D.; Ishihara, Koji. The article conveys some information:

Fundamental information on the reactivities of boronic acids toward catechols in aqueous solution is required in all the fields dealing with boronic acid. However, comprehensive studies on reactivity are often hindered by so-called “”proton ambiguity,”” which makes it impossible for the rate constants of boronic acid and boronate ion to be determined sep. Herein, we set up two reaction systems without proton ambiguity: (1) Alizarin Red S and (2) Tiron with several boronic acids (RB(OH)2) with different pKa’s and performed kinetic and equilibrium studies on the reaction systems. It was shown that the logarithms of the rate constants of RB(OH)2 and its conjugate boronate ion (RB(OH)3-) decreased and increased linearly, resp., with increasing pKa of RB(OH)2 for both systems. Consequently, the reactivities of RB(OH)2 and RB(OH)3- were reversed at high RB(OH)2 pKa. It was also shown that the bulky o-substituents of phenylboronic acids retarded the backward reactions, resulting in enhancement of the formation constants of boronic acid-catechol esters. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7COA of Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Su; Lei, Yang; Guo, Jing; Huang, Jian-Feng; Hou, Chao-Ping; Liu, Jun-Min published an article in 2021. The article was titled 《Constructing Heterogeneous Direct Z-Scheme Photocatalysts Based on Metal-Organic Cages and Graphitic-C3N4 for High-Efficiency Photocatalytic Water Splitting》, and you may find the article in ACS Applied Materials & Interfaces.Electric Literature of C5H6BNO2 The information in the text is summarized as follows:

The development of artificial devices that mimic the highly efficient and ingenious photosystems in nature is worthy of in-depth study. A metal-organic cage (MOC) Pd2(M-4)4(BF4)4, denoted as MOC-Q1, integrating four organic photosensitized ligands M-4 and two Pd2+ catalytic centers is designed for a photochem. mol. device (PMD). MOC-Q1 is successfully immobilized on graphitic carbon nitride (g-C3N4) by hydrogen bonds to obtain a robust heterogeneous direct Z-scheme g-C3N4/MOC-Q1 photocatalyst for H2 generation under visible light. The optimized g-C3N4/MOC-Q1 (2 wt %) system shows high hydrogen evolution activity (4495 μmol g-1 h-1 based on the catalyst mass) and exhibits stable performances for 25 h (a turnover number of 19,268 based on MOC-Q1), significantly outperforming pure MOC-Q1, g-C3N4, and comparsion materials Pd/g-C3N4/M-4, which is the highest one of all reported heterogeneous MOC-based photocatalysts under visible irradiation This enhancement can be ascribed to the synergistic effects of high-efficient electron transfer, extended visible-light response region, and good protective environment for MOC-Q1 arising from an efficient direct Z-scheme heterostructure of g-C3N4/MOC-Q1. This rationally designed and synthesized MOC/g-C3N4-based heterogeneous PMD is expected to have great potential in photocatalytic water splitting. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of Pyridin-3-ylboronic acidIn 2022 ,《Facile Synthesis of 2-Methylnicotinonitrile through Degenerate Ring Transformation of Pyridinium Salts》 appeared in Journal of Organic Chemistry. The author of the article were Duan, Xiaoxia; Sun, Rui; Tang, Juan; Li, Shun; Yang, Xiao; Zheng, Xueli; Li, Ruixiang; Chen, Hua; Fu, Haiyan; Yuan, Maolin. The article conveys some information:

Nucleophilic recyclization of pyridinium salts involving a CCN interchange ring transformation for the synthesis of 2-methylnicotinonitrile derivatives was herein developed. 3-Aminocrotononitrile (3-ACN) produced in situ from CH3CN acted as a C-nucleophile, as well as the source of CH3 and CN groups, which was supported by isotope-labeling and control experiments In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1692-25-7In 2021 ,《Supramolecular Engineering Strategy to Construct BODIPY-Based White Light Emission Materials》 was published in Chemistry – An Asian Journal. The article was written by Li, Fang-Zhou; Zhou, Liang-Liang; Kuang, Gui-Chao. The article contains the following contents:

Two kinds of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dyads BDP-OH containing 4-hydroxystyrene groups and BDP-PY bearing pyridinyl units were prepared In addition, a naphthalene derivative NAP-PY modified by pyridinyl moieties substituent was made. The above three dyads could be used to construct white-light emission (WLE) material by a supramol. engineering strategy due to their three primary colors of blue, green and red. The supramol. correlations between the hydroxyl group of BDP-OH and the pyridinyl groups of NAP-PY and BDP-PY were confirmed by 1H NMR titration, 2D NOESY and FTIR. A fluorescence monitor application was carried out based on the realization of WLE. This work might be useful for designing other WLE supramol. systems and image display. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ahmad, Gulraiz; Rasool, Nasir; Qamar, Muhammad Usman; Alam, Mohammed Mujahid; Kosar, Naveen; Mahmood, Tariq; Imran, Muhammad published their research in Arabian Journal of Chemistry in 2021. The article was titled 《Facile synthesis of 4-aryl-N-(5-methyl-1H-pyrazol-3-yl)benzamides via Suzuki Miyaura reaction: Antibacterial activity against clinically isolated NDM-1-positive bacteria and their Docking Studies》.Synthetic Route of C5H6BNO2 The article contains the following contents:

The production of new pyrazole amide derivatives I (Ar = 4-AcC6H4, 4-ClC6H4, 4-MeOC6H4, etc.) and their potential against New Delhi metallo-β-lactamase-1 (NDM-1) producing bacteria was described in the present manuscript. The 4-bromo-N-(5-methyl-1H-pyrazol-3-yl)benzamide was synthesized via direct amidation of protected 5-methyl-1H-pyrazol-3-amine. The target pyrazole amide derivatives I were synthesized in moderate to excellent yield via Palladium catalyzed Suzuki cross-coupling of intermediate mol. with different aryl and heteroaryl boronic acids. The in vitro antibacterial effect against NDM-1-pos. Acinetobacter baumannii and Klebsiella pneumoniae of newly synthesized analogs I were determined by Agar well diffusion method. Moreover, MIC and MBC values were also evaluated against the tested bacteria. In addition, the Mol. Docking study of pyrazole amide derivatives I against the NDM producing A. baumannii was performed to investigate the intermol. interaction. The binding affinity and their values were compared with L-captopril. The I (Ar = 3-ClC6H4) had greatest potential value and was appeared as a promising antibacterial agent.Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem