Category: 1692-25-7

Lu, Ru-Qiang; Zhuo, You-Zhen; Bao, Yue-Hua; Yang, Lin-Lin; Qu, Hang; Tang, Xiao; Wang, Xin-Chang; Li, Zhi-Hao; Cao, Xiao-Yu published their research in Chemistry – A European Journal in 2021. The article was titled 《Cyclopentadienone Derivative Dimers as Tunable Photoswitches》.Recommanded Product: Pyridin-3-ylboronic acid The article contains the following contents:

A series of photoswitchable cyclopentadienone derivative dimers bearing bromo, thienyl, 4-(dimethylamino)phenyl, 3-pyridinyl, 4-nitrophenyl and cyano groups was designed and facilely synthesized. Photoswitching properties such as the photoconversions in the photostationary state (PSS), the thermal kinetics and thermal half-lives of photoisomers were systematically studied. These photoswitches show high fatigue resistance and large photoconversions in the PSS. This work proves that the photoswitching properties of photoswitches based on cyclopentadienone dimers can be tuned by substitution groups and also pave the way to functionalize the cyclopentadienone derivative dimer-based photoswitch, which is important for its future applications. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Lei; Yu, Jiancheng; Xie, Chengyi; Wang, Chenlu; Guan, Pengfei; Hu, Jun Jack; Tang, Keqi published their research in Analyst (Cambridge, United Kingdom) in 2021. The article was titled 《A TIMS-TOF mass spectrometry study of disaccharides from in situ ESI derivatization with 3-pyridinylboronate》.Application In Synthesis of Pyridin-3-ylboronic acid The article contains the following contents:

3-Pyridinylboronate, a zwitterionic boronic acid, displayed effective in situ ESI for reversible covalent tagging of saccharides in both cation and anion modes. The ion mobilities of thus-generated ions were examined with the Bruker TIMS-TOF fleX instrument. Nine disaccharides were examined using this method. They have identical mass-to-charge ratios, differing only in monomer compositions, regio-linkages, and anomeric configurations (α or β). The IMS separations of the disaccharides from this method were compared with those from sodium adducts reported in the literature. The differentiation effects of this method on the disaccharide isomers were increased on average by an order of magnitude. Using this method, all the pairs of disaccharides selected from nine isomers were completely identified by comparing the mobility spectra of single-tagged and double-tagged ions. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kanao, Eisuke; Tsuchiya, Yuko; Tanaka, Kei; Masuda, Yusuke; Tanigawa, Tetsuya; Naito, Toyohiro; Sano, Tomoharu; Kubo, Takuya; Otsuka, Koji published an article in 2021. The article was titled 《Poly(ethylene glycol) Hydrogels with a Boronic Acid Monomer via Molecular Imprinting for Selective Removal of Quinic Acid Gamma-Lactone in Coffee》, and you may find the article in ACS Applied Polymer Materials.HPLC of Formula: 1692-25-7 The information in the text is summarized as follows:

We developed molecularly imprinted polymers (MIPs) with a poly(ethylene glycol) (PEG)-based cross-linker and boronic acids in functional monomers, which selectively form a complex with a diol structure for selective removal of lactones from a coffee beverage. We synthesized a boronic acid monomer, 1-allylpyridinium-3-boronic acid, which has lower pKa and stronger binding strength to saccharides than commonly used boronic acids. Then, we prepared the MIPs with the monomer and succeeded in selective adsorption for a type of lactones, quinic acid gamma-lactone (QAGL). Furthermore, the high hydrophilicity of PEG and the mol. imprinting effect prevented an un-specific adsorption of other components in coffee. Finally, we achieved in removal of QAGL in coffee with high yield and at high speed by using the MIP-based microsphere as a separation medium in solid-phase extraction This study provides a simple method for better-tasting freshly brewed coffee. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1692-25-7In 2022 ,《Article on 3-Pyridinylboronic Acid Ameliorates Rotenone-Induced Oxidative Stress Through Nrf2 Target Genes in Zebrafish Embryos》 appeared in Neurochemical Research. The author of the article were Ustundag, Fumet Duygu; Unal, Ismail; Ustundag, Unsal Veli; Cansiz, Derya; Beler, Merih; Karagoz, Atakan; Kara Subasat, Hulya; Alturfan, A. Ata; Mega Tiber, Pinar; Emekli-Alturfan, Ebru. The article conveys some information:

Parkinsons disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone is a neurotoxin that can pass the blood-brain barrier and is used to generate PD models in exptl. animals. Boron is a microelement necessary for neural activity in the brain. Antioxidant, non-cytotoxic, anti-genotoxic, anti-carcinogenic effects of boric acid, the salt compound of boron has been reported before. Boronic acids have been approved for treatment by FDA and are included in drug discovery studies and pyridine boronic acids are a subclass of heterocyclic boronic acids used in drug design and discovery as substituted pyridines based on crystal engineering principles. The aim of our study was to determine the effect of 3-pyridinylboronic acid in rotenone-exposed zebrafish embryos, focusing on oxidant-antioxidant parameters and gene expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) target genes gclm, gclc, hmox1a, nqo1, and PD related genes, brain-derived neurotrophic factor, dj1, and tnfα. Zebrafish embryos were exposed to Rotenone (10μg/l); Low Dose 3-Pyridinylboronic acid (100μM); High Dose 3-Pyridinylboronic acid (200μM); Rotenone + Low Dose-3-Pyridinylboronic acid (10μg/l + 100μM); Rotenone + High Dose-3-Pyridinylboronic acid (10μg/l + 200μM) in well plates for 96 h post-fertilization (hpf). Our study showed for the first time that 3-pyridinylboronic acid, as a novel sub-class of the heterocyclic boronic acid compound, improved locomotor activities, ameliorated oxidant-antioxidant status by decreasing LPO and NO levels, and normalized the expressions of bdnf, dj1, tnf and Nrf2 target genes hmox1a and nqo1 in rotenone exposed zebrafish embryos. On the other hand, it caused the deterioration of the oxidant-antioxidant balance in the control group through increased lipid peroxidation, nitric oxide levels, and decreased antioxidant enzymes. We believe that these results should be interpreted in the context of the dose-toxicity and benefit-harm relationship of the effects of 3-pyridinylboronic. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Baran, Andrei; Babkova, Mariia; Petkus, Jana; Shubin, Kirill published an article in Applied Organometallic Chemistry. The title of the article was 《Suzuki-Miyaura arylation of 2,3-, 2,4-, 2,5-, and 3,4-dibromothiophenes》.Safety of Pyridin-3-ylboronic acid The author mentioned the following in the article:

A convenient and general method for Suzuki-Miyaura double cross-coupling of boronic acid with dibromothiophenes was developed to form diarylthiophenes I [Ar = Ph, 4-ClC6H4, 4-NCC6H4, etc.] using a simple and cheap catalytic system Pd(OAc)2/PPh3 in 95% EtOH. The overall efficiency of the catalytic process and slight excess of boronic acids allowed to suppress formation of side products and significantly simplify the purification of products. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1692-25-7In 2020 ,《Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Teng, Yu; Li, Xinyu; Ren, Shengnan; Cheng, Yu; Xi, Kun; Shen, Hongtao; Ma, Wenzhuo; Luo, Guoshun; Xiang, Hua. The article conveys some information:

Herein, a series of quinazoline derivatives I [R1 = Br, 3-pyridyl, (6-fluoro-3-pyridyl), (6-chloro-3-pyridyl), 3-quinolyl; R2 = vinyl, Et, HC=CH2CH3, C≡CCH3; R3 = H, Me] bearing acrylamide fragment were prepared using skeleton-deconstruction strategy. The preliminary bioactivity evaluation resulted in the discovery of lead compound I [R1 = 3-quinolyl; R2 = vinyl; R3 = Me]. Compound I [R1 = 3-quinolyl; R2 = vinyl; R3 = Me] exhibited excellent enzyme activity against PI3Kδ (IC50 = 27.5 nM) compared with BEZ235 as well as the significant anti-proliferation activities. With the high selectivity over other PI3K isoforms and potent effects on PI3K/Akt pathway, compoundI [R1 = 3-quinolyl; R2 = vinyl; R3 = Me] could be identified as a promising PI3Kδ inhibitor worthy of further profiling. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Screen of Unfocused Libraries Identified Compounds with Direct or Synergistic Antibacterial Activity》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to Mugnaini, Claudia; Sannio, Filomena; Brizzi, Antonella; Del Prete, Rosita; Simone, Tiziana; Ferraro, Teresa; De Luca, Filomena; Corelli, Federico; Docquier, Jean-Denis. Product Details of 1692-25-7 The article mentions the following:

Antibiotic resistance is an increasingly important global public health issue, as major opportunistic pathogens are evolving toward multidrug- and pan-drug resistance phenotypes. New antibiotics are thus needed to maintain our ability to treat bacterial infections. According to the WHO, carbapenem-resistant Acinetobacter, Enterobactericaeae, and Pseudomonas are the most critical targets for the development of new antibacterial drugs. An automated phenotypic screen was implemented to screen 634 synthetic compounds obtained inhouse for both their direct-acting and synergistic activity. Fourteen percent and 10% of the compounds showed growth inhibition against tested Gram-pos. and Gram-neg. bacteria, resp. The most active direct-acting compounds showed a broad-spectrum antibacterial activity, including on some multidrug-resistant clin. isolates. In addition, 47 compounds were identified for their ability to potentiate the activity of other antibiotics. Compounds of three different scaffolds (2-quinolones, phenols, and pyrazoles) showed a strong potentiation of colistin, some being able to revert colistin resistance in Acinetobacter baumannii.Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaur, Gurpreet; Sinha, Avisikta; Ravikanth, Mangalampalli published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Synthesis of Mono β-Pyrrole Substituted Triphyrin(2.1.1)s》.Category: pyridine-derivatives The article contains the following contents:

A series of ten mono β-substituted triphyrin(2.1.1)s I [R = Me, Ph, 4-pyridyl, etc.] were synthesized by coupling mono β-bromo triphyrin(2.1.1) I [R = Br] with appropriate boronic acid in THF/toluene/water (1 : 1 : 1) in the presence of a catalytic amount of Pd(PPh3)4 in 17-67% yields. Different boronic acids such as Me, Ph, p-tolyl, p-anisyl, p-fluorophenyl, p-chlorophenyl, 3-thienyl, 3-pyridyl, 4-pyridyl, p-biphenyl boronic acids were used. This synthetic approach to β-substituted triphyrin(2.1.1)s I was facile. The mono-β-substituted triphyrin(2.1.1)s I were characterized and studied by mass spectrometry, NMR, absorption, electrochem. and DFT/TD-DFT techniques. The spectral studies indicated slight alterations in their electronic properties due to presence of an alkyl/aryl/heteroaryl substituent at the β-pyrrole carbon. DFT studies indicated that the pyrrole ring which was substituted with alkyl group at its β-position exhibited more deviation compared to the other two pyrroles of triphyrin(2.1.1) I macrocycle from the mean plane. However, the β-aryl/heteroaryl substituted pyrrole showed less deviation from the mean plane and overall β-aryl/heteroaryl macrocycle was planar. Furthermore, the studies also supported the participation of a β-substituent with π-delocalization of triphyrin(2.1.1) I. TD-DFT studies support the exptl. observations. The experimental part of the paper was very detailed, including the reaction process of Pyridin-3-ylboronic acid(cas: 1692-25-7Category: pyridine-derivatives)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1692-25-7In 2021 ,《Catalytic Enantioselective Synthesis of Pyridyl Sulfoximines》 appeared in Journal of the American Chemical Society. The author of the article were Tang, Yu; Miller, Scott J.. The article conveys some information:

The synthesis of chiral sulfoximines, e.g., I, through the desymmetrizing N-oxidation of pyridyl sulfoximines, e.g., II, using an aspartic-acid-containing peptide catalyst III (R = Ts, Boc) was reported. Various mono- and bis-pyridyl sulfoximine oxides, e.g., I and IV, are obtained with up to 99:1 er. The directing group introduced on the substrate highly enhances the enantioinduction and could be easily removed to give the free N-H sulfoximines V. Addnl., peptides with Me ester and the Me amide C-terminal protecting group give the opposite enantiomers of the product. A binding model is proposed to explain this phenomenon. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Wenwu; Liu, Xin; Tian, Liting; Gao, Yaping; Liu, Wenjie; Chen, Huanhua; Jiang, Xiaowen; Xu, Zihua; Ding, Huaiwei; Zhao, Qingchun published an article in 2021. The article was titled 《Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer’s disease》, and you may find the article in European Journal of Medicinal Chemistry.HPLC of Formula: 1692-25-7 The information in the text is summarized as follows:

Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss and behavioral disturbances, ultimately leading to death. Glycogen synthase kinase 3β (GSK-3β) and dual-specificity tyrosine phosphorylation regulated kinase1A (DYRK1A) have gained a lot of attention for its role in tau pathol. To search for potential dual GSK-3β/DYRK1A inhibitors, we focused on harmine, a natural β-carboline alkaloid, which has been extensively studied for its various biol. effects on the prevention of AD. In this study, a new series of harmine derivatives were designed, synthesized and evaluated as dual GSK-3β/DYRK1A inhibitors for their multiple biol. activities. The in vitro results indicated that most of them displayed promising activity against GSK-3β and DYRK1A. Among them, compound ZDWX-25 (I) showed potent inhibitory effects on GSK-3β and DYRK1A with IC50 values of 71 and 103 nM, resp. Mol. modeling and kinetic studies verified that ZDWX-25 could interact with the ATP binding pocket of GSK-3β and DYRK1A. Western blot anal. revealed that ZDWX-25 inhibited hyperphosphorylation of tau protein in okadaic acid (OKA)-induced SH-SY5Y cells. In addition, ZDWX-25 showed good blood-brain barrier penetrability in vitro. More importantly, ZDWX-25 could ameliorate the impaired learning and memory in APP/PS1/Tau transgenic mice. These results indicated that the harmine-based compounds could be served as promising dual-targeted candidates for AD. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem