Category: 1692-25-7

The author of 《Halide-Rebound Polymerization of Twisted Amides》 were Fu, Liangbing; Xu, Mizhi; Yu, Jiyao; Gutekunst, Will R.. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: Pyridin-3-ylboronic acid The author mentioned the following in the article:

The first living polymerization of twisted amides is reported, achieved using simple primary alkyl iodides as initiators. Polymerization occurs through a halide-rebound mechanism in which the nucleophilic twisted amide is quaternized and subsequently ring-opened by the iodide counterion. The covalent electrophilic polymerization generates polymers with living chain ends that are both isolable and stable to ambient conditions, enabling the synthesis of block polymers. This presents a new class of polymers for study that possess high glass transition temperatures and robust thermal stability. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and antifungal activity of imidazo[1,2-b]pyridazine derivatives against phytopathogenic fungi》 was written by Fan, Lingling; Luo, Zhongfu; Li, Yi; Liu, Xinyun; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong. Formula: C5H6BNO2 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

A series of 3,6-disubstituted imidazo[1,2-b]pyridazine derivatives were synthesized and characterized with spectroscopic analyses. The antifungal activities of these compounds against nine phytopathogenic fungi were evaluated by the mycelium growth rate method. The in vitro antifungal bioassays indicated that most of compounds displayed excellent and broad-spectrum antifungal activities. Especially, compounds 6-chloro-3-phenylimidazo[1,2-b]pyridazine, 6-chloro-3-(2-fluorophenyl)imidazo[1,2-b]pyridazine, 6-chloro-3-(2-chlorophenyl)imidazo[1,2-b]pyridazine, 6-chloro-3-(thiophen-3-yl)imidazo[1,2-b]pyridazine and 6-methoxy-3-phenylimidazo[1,2-b]pyridazine exhibited 1.9-25.5 fold more potent than the com. available fungicide hymexazol against Corn Curvalaria Leaf Spot (CL), Alternaria alternate (AA), Pyricularia oryzae (PO) and Alternaria brassicae (AB) strains. Structure-activity relation anal. showed that the enhanced antifungal activity is significantly affected by the substituents on the benzene ring and pyridazine ring. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duan, Ying-Chao; Jin, Lin-Feng; Ren, Hong-Mei; Zhang, Shao-Jie; Liu, Yue-Jiao; Xu, Yong-Tao; He, Zi-Hao; Song, Yu; Yuan, Hang; Chen, Shu-Hui; Guan, Yuan-Yuan published an article in 2021. The article was titled 《Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer》, and you may find the article in European Journal of Medicinal Chemistry.Safety of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

A series of novel LSD1/HDAC bifunctional inhibitors with a styrylpyridine skeleton I [meta-, para-substituted; X = CH, N; R = H, 3-thienyl, 2-hydroxy-5-fluorophenyl, etc; R1 = H, F], II and III [R2 = H, F; R3 = H, Me, F3C; R4 = H, F, HO, MeO] were designed and synthesized based on our previously reported LSD1 inhibitors. The representative compounds I [para-substituted; X = N; R = 2-hydroxyphenyl, 2-fluoro-4-methylphenyl; R1 = H] showed potent activity against LSD1 and HDAC at both mol. and cellular level and displayed high selectivity against MAO-A/B. Compounds I [para-substituted; X = N; R = 2-hydroxyphenyl, 2-fluoro-4-methylphenyl; R1 = H] demonstrated potent antiproliferative activities against MGC-803 and HCT-116 cancer cell lines. Compound I [para-substituted, X = N, R = 2-fluoro-4-methylphenyl, R1 = H] showed superior in-vitro anticancer potency against a panel of gastric cancer cell lines than ORY-1001 and SP-2509 with IC50 values ranging from 0.23 to 1.56μM. Compounds I [para-substituted; X = N; R = 2-hydroxyphenyl, 2-fluoro-4-methylphenyl; R1 = H] significantly modulated the expression of Bcl-2, Bax, Vimentin, ZO-1 and E-cadherin, induced apoptosis, reduced colony formation and suppressed migration in MGC-803 cancer cells. In addition, preliminary absorption, distribution, metabolism, excretion (ADME) studies revealed that compounds I [para-substituted; X = N; R = 2-hydroxyphenyl, 2-fluoro-4-methylphenyl; R1 = H] showed acceptable metabolic stability in human liver microsomes with minimal inhibition of cytochrome P450s (CYPs). Those results indicated that compound I [para-substituted, X = N, R = 2-fluoro-4-methylphenyl, R1 = H] could be a promising lead compound for further development as a therapeutic agent in gastric cancers via LSD1 and HDAC dual inhibition. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tarzia, Andrew; Lewis, James E. M.; Jelfs, Kim E. published an article in 2021. The article was titled 《High-Throughput Computational Evaluation of Low Symmetry Pd2L4 Cages to Aid in System Design》, and you may find the article in Angewandte Chemie, International Edition.Recommanded Product: 1692-25-7 The information in the text is summarized as follows:

Unsym. ditopic ligands can self-assemble into reduced-symmetry Pd2L4 metallo-cages with anisotropic cavities, with implications for high specificity and affinity guest-binding. Mixtures of cage isomers can form, however, resulting in undesirable system heterogeneity. It is paramount to be able to design components that preferentially form a single isomer. Previous data suggested that computational methods could predict with reasonable accuracy whether unsym. ligands would preferentially self-assemble into single cage isomers under constraints of geometrical mismatch. Authors successfully apply a collaborative computational and exptl. workflow to mitigate costly trial-and-error synthetic approaches. Their rapid computational workflow constructs unsym. ligands and their Pd2L4 cage isomers, ranking the likelihood for exclusively forming cis-Pd2L4 assemblies. From this narrowed search space, we successfully synthesized four new, low-symmetry, cis-Pd2L4 cages. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Graphene Oxide as a Carbocatalyst for Sustainable ipso-Hydroxylation of Arylboronic Acids: A Simple and Straightforward Strategy To Access Phenols》 were Karthik, Murugan; Suresh, Palaniswamy. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. COA of Formula: C5H6BNO2 The author mentioned the following in the article:

A metal-free and straightforward protocol for the synthesis of phenols from aryl and heteroaryl boronic acids has been demonstrated using graphene oxide as a carbocatalyst. This sustainable ipso-hydroxylation takes place under mild conditions using aqueous H2O2 as an oxidant in a water medium in a short time under organocatalytic and base-free conditions. The control experiments reveal that the presence of carboxyl groups promotes ipso-hydroxylation. The developed methodol. offers GO as a benign solid-acid catalyst with good sustainability which can be reused several times without significant loss in its catalytic activities; this was proven by the Fourier transform IR and powder X-ray diffraction studies of the reused catalyst. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7COA of Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Asymmetric remote C-H borylation of aliphatic amides and esters with a modular iridium catalyst》 was published in Science (Washington, DC, United States) in 2020. These research results belong to Reyes, Ronald L.; Sato, Miyu; Iwai, Tomohiro; Suzuki, Kimichi; Maeda, Satoshi; Sawamura, Masaya. Electric Literature of C5H6BNO2 The article mentions the following:

Site selectivity and stereocontrol remain major challenges in C-H bond functionalization chem., especially in linear aliphatic saturated hydrocarbon scaffolds. We report the highly enantioselective and site-selective catalytic borylation of remote C(sp3)-H bonds γ to the carbonyl group in aliphatic secondary and tertiary amides and esters. A chiral C-H activation catalyst was modularly assembled from an iridium center, a chiral monophosphite ligand, an achiral urea-pyridine receptor ligand, and pinacolatoboryl groups. Quantum chem. calculations support an enzyme-like structural cavity formed by the catalyst components, which bind the substrate through multiple noncovalent interactions. Versatile synthetic utility of the enantioenriched γ-borylcarboxylic acid derivatives was demonstrated. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Manley, Paul W.; Huth, Felix; Moussaoui, Saliha; Schoepfer, Joseph published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《A kinase inhibitor which specifically targets the ABL myristate pocket (STAMP), but unlike asciminib crosses the blood-brain barrier》.Computed Properties of C5H6BNO2 The author mentioned the following in the article:

The ubiquitously expressed ABL1 and ABL2 protein kinases play many important roles in cell function. Although they have been implicated in neuron development, maintenance and signaling, there are no good tool compounds to evaluate the effects of ABL kinase inhibition in the brain. Asciminib is a recently approved drug that specifically and potently inhibits the tyrosine kinase activity of ABL1, ABL2 and that of the chimeric BCR-ABL1 oncoprotein which causes chronic myeloid leukemia. Herein we show that asciminib does not penetrate the intact blood-brain barrier (BBB) following administration to rats, which curtails its utility for assessing the in vivo effects of ABL kinase inhibition in the brain. However, we describe another specific ABL kinase inhibitor, possessing physicochem. characteristics suitable for BBB penetration, and which after administration (either i.v., i.p. or p.o.) to mice achieves substantial, pharmacol. relevant brain concentrations This bipyridine compound (4) therefore has potential for elucidating the role of ABL kinases in the brain in non-clin. studies. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Computed Properties of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1692-25-7In 2019 ,《Red/Near-Infrared Thermally Activated Delayed Fluorescence OLEDs with Near 100 % Internal Quantum Efficiency》 was published in Angewandte Chemie, International Edition. The article was written by Chen, Jia-Xiong; Tao, Wen-Wen; Chen, Wen-Cheng; Xiao, Ya-Fang; Wang, Kai; Cao, Chen; Yu, Jia; Li, Shengliang; Geng, Feng-Xia; Adachi, Chihaya; Lee, Chun-Sing; Zhang, Xiao-Hong. The article contains the following contents:

Developing red thermally activated delayed fluorescence (TADF) emitters, attainable for both high-efficient red organic light-emitting diodes (OLEDs) and non-doped deep red/near-IR (NIR) OLEDs, is challenging. Now, two red emitters, BPPZ-PXZ and mDPBPZ-PXZ, with twisted donor-acceptor structures were designed and synthesized to study mol. design strategies of high-efficiency red TADF emitters. BPPZ-PXZ employs the strictest mol. restrictions to suppress energy loss and realizes red emission with a photoluminescence quantum yield (ΦPL) of 100±0.8 % and external quantum efficiency (EQE) of 25.2 % in a doped OLED. Its non-doped OLED has an EQE of 2.5 % owing to unavoidable intermol. π-π interactions. MDPBPZ-PXZ releases two pyridine substituents from its fused acceptor moiety. Although mDPBPZ-PXZ realizes a lower EQE of 21.7 % in the doped OLED, its non-doped device shows a superior EQE of 5.2 % with a deep red/NIR emission at peak of 680 nm. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hosseini, Raziyeh; Ranjbar-Karimi, Reza; Mohammadiannejad, Kazem published an article in 2022. The article was titled 《3,3′-((Arylmethylene)bis(4-methoxy-3,1-phenylene)) dipyridine derivatives as convenient ligands for Suzuki-Miyaura chemo- and homoselective cross-coupling reactions》, and you may find the article in Journal of the Iranian Chemical Society.Product Details of 1692-25-7 The information in the text is summarized as follows:

Four novel N,N-bidentate triarylmethane-based ligands I [Ar = Ph, 4-methylphenyl, 3-nitrophenyl] bearing β-pyridyl residues have been prepared and the catalytic activity of their in-situ generated palladium complexes were studied in the Suzuki-Miyaura cross-coupling reactions. Air and moisture stable 3,3′-((arylmethylene)bis(4-methoxy3,1-phenylene))dipyridines I showed excellent activity in the Suzuki coupling reactions of aryl halides with aryl boronic acids under thermal and sonochem. reaction conditions. The described methodol. provided good to high yields in short reaction times at ambient conditions. Moreover, it offered a straightforward way for Suzuki-Miyaura chemo- and homoselective cross-coupling of aryl halides with Ph boronic acid. The structures of synthesized compounds were fully characterized by FT-IR, 1H-NMR, 13C-NMR, and elemental analyses. The coordination of palladium acetate to nitrogen sites of I [Ar = Ph] was also studied using FTIR spectroscopy, EDX anal. and SEM observations. The in-situ generated Pd-complexes of N,N-bidentate ligands I were described as robust and highly effective catalytic systems for the Suzuki cross-coupling of aryl halides with aryl boronic acids under thermal and sonochem. reaction conditions. In addition to this study using Pyridin-3-ylboronic acid, there are many other studies that have used Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2022 ,《Effects of 3-Pyridinylboronic acid in zebrafish enmbryos exposed to neurotoxin,1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine》 appeared in Drug and Chemical Toxicology (1977). The author of the article were Ustundag, Fumet Duygu; Unal, Ismail; Cansiz, Derya; Ustundag, Unsal Veli; Subasat, Hulya Kara; Alturfan, A. Ata; Tiber, Pinar Mega; Emekli-Alturfan, Ebru. The article conveys some information:

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the mol. pathways in the pathogenesis of Parkinson disease and also for potential therapeutic agent research. Boron has been shown to play an important role in the neural activity of the brain. Boronic acids are used in combinatorial approaches in drug design and discovery. The effect of 3-pyridinylboronic acid which is an important sub-class of heterocyclic boronic acids has not been evaluated in case of MPTP exposure in zebrafish embryos. Accordingly, this study was designed to investigate the effects of 3-pyridinylboronic acid on MPTP exposed zebrafish embryos focusing on the mol. pathways related to neurodegeneration and apoptosis by RT-PCR. Zebrafish embryos were exposed to MPTP (800μM); MPTP + Low Dose 3-Pyridinylboronic acid (50μM) (MPTP + LB) and MPTP + High Dose 3-Pyridinylboronic acid (100μM) (MPTP + HB) in well plates for 72 h post fertilization. Results of our study showed that MPTP induced a P53 dependent and Bax mediated apoptosis in zebrafish embryos and 3-pyridinylboronic acid restored the locomotor activity and gene expressions related to mitochondrial dysfunction and oxidative stress due to the deleterious effects of MPTP, in a dose-dependent manner. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Category: pyridine-derivatives)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem