Category: 170235-18-4

Kanno, Hisashi et al. published their patent in 1999 |CAS: 170235-18-4

The Article related to phenoxypicolinic acid alkylidenehydrazide preparation herbicide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: pyridine-derivatives

On January 7, 1999, Kanno, Hisashi; Yoshida, Kazuo; Sato, Tsutomu; Sato, Kobi; Kanda, Yoichi published a patent.Category: pyridine-derivatives The title of the patent was Preparation of 6-phenoxypicolinic acid alkylidenehydrazide derivatives as herbicides. And the patent contained the following:

Claimed are 6-Phenoxypicolinic acid alkylidenehydrazide derivatives [I; R1 = halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, C1-4 alkylamino, C1-4 dialkylamino, (C1-4 alkyl)(C7-8aralkyl)amino; m = 0-3; R2, R3 = H, C1-10 C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, Ph, or aryl-C1-3 alkyl each optionally substituted with Xa or Xb; ; X1, Xb = halo, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkyl, C3-6 cycloalkyl, or cyano; na = nb = 0 or integer selected from number of H atoms substitutable with Xa and Xb in R2 and R3; or when R2 and R3 are an alkyl chain, R2 and R3 are directly linked together to form a ring optionally interposed with O, S, or optionally C1-4 alkyl-substituted NH; Y = C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, or halo; p = 0-5; when m, n, na, nb, and p are ≥2, R1, R2, Xa, Xb, and Y are same or different groups], a process for producing these, and a herbicide containing any of the derivatives as the active ingredient. These compounds exhibit excellent herbicidal activity with high selectivity at low dosage and does not inflict damage to the subsequent crops in double-cropping. Thus, 6-methoxy-6-[3-(trifluoromethyl)phenoxy]picolinic acid was stirred with chloroacetaldehyde in a mixture of 40% aqueous NaOH and EtOH at room temperature for ∼4 h to give 88% 6-methoxy-6-[3-(trifluoromethyl)phenoxy]picolinic acid (2-chloroethylidene)hydrazide (II). II 100 g/10 post emergence are controlled ≥50% Amaranthus retroflexus, Brassica kaber, Solanum nigrum, and Galium spurium. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Category: pyridine-derivatives

The Article related to phenoxypicolinic acid alkylidenehydrazide preparation herbicide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kanno, Hisashi et al. published their patent in 1998 |CAS: 170235-18-4

The Article related to phenoxypicolinic acid preparation agrochem fungicide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 170235-18-4

On July 9, 1998, Kanno, Hisashi; Kanda, Yoichi; Sunagawa, Kazuhiko; Eizuka, Takayoshi published a patent.SDS of cas: 170235-18-4 The title of the patent was Preparation of phenoxypicolinic acid derivatives as agrochemical fungicides. And the patent contained the following:

The title compounds [I; R = halo, C1-4 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, or alkylamino, etc.; n1 = 1-3; Y = C1-4 alkyl, haloalkyl, alkoxy, or haloalkoxy, etc.; m = 0-5] are prepared I are useful as active ingredients contained in agricultural or horticultural fungicides. Thus, 2-bromo-4-methoxy-6-[3-(trifluoromethyl)phenoxy]pyridine (preparation given) was treated with n-BuLi, reacted with CO2, and treated with 1N HCl to give 30% I (Rn1 = 4-OMe, Ym = 3-CF3), which at 1 kg/ha showed > 70% fungicidal effect for Botrytis cinerea. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).SDS of cas: 170235-18-4

The Article related to phenoxypicolinic acid preparation agrochem fungicide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 170235-18-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kelly, T. Ross et al. published their research in Journal of Organic Chemistry in 1996 |CAS: 170235-18-4

The Article related to sulfomycinamate preparation, oxazole triflate preparation coupling reaction, pyridyl triflate preparation coupling thiazole, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Safety of Methyl 6-bromo-5-methoxypicolinate

On July 12, 1996, Kelly, T. Ross; Lang, Fengrui published an article.Safety of Methyl 6-bromo-5-methoxypicolinate The title of the article was Total Synthesis of Dimethyl Sulfomycinamate. And the article contained the following:

Di-Me sulfomycinamate, a methanolysis product from the natural antibiotic sulfomycin I, is synthesized in 11 steps. The chem. of various pyridine, thiazole, and oxazole heterocycles and their coupling reactions under palladium catalysis are examined The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions on a doubly-activated pyridine and the condensation reaction between bromo ketone and amide to form the oxazole moiety. The first preparation of oxazole triflates is described, as is some of their chem. properties. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Safety of Methyl 6-bromo-5-methoxypicolinate

The Article related to sulfomycinamate preparation, oxazole triflate preparation coupling reaction, pyridyl triflate preparation coupling thiazole, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Safety of Methyl 6-bromo-5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kelly, T. Ross et al. published their research in Tetrahedron Letters in 1995 |CAS: 170235-18-4

The Article related to sulfomycinamate total synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Quality Control of Methyl 6-bromo-5-methoxypicolinate

On July 24, 1995, Kelly, T. Ross; Lang, Fengrui published an article.Quality Control of Methyl 6-bromo-5-methoxypicolinate The title of the article was Total synthesis of dimethyl sulfomycinamate. And the article contained the following:

The first total synthesis of di-Me sulfomycinamate is described. Highlights of the synthesis include a selective palladium-catalyzed coupling reaction on a bromo triflate, and a condensation reaction to form the oxazole ring. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Quality Control of Methyl 6-bromo-5-methoxypicolinate

The Article related to sulfomycinamate total synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Quality Control of Methyl 6-bromo-5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Magda, Darren et al. published their patent in 2014 |CAS: 170235-18-4

The Article related to dimacrocycle preparation complex therapeutic and diagnostic application, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Product Details of 170235-18-4

On May 22, 2014, Magda, Darren; Xu, Jide; Butlin, Nathaniel G. published a patent.Product Details of 170235-18-4 The title of the patent was Preparation of di-macrocycles and their complexes for use in therapeutics and diagnostic applications. And the patent contained the following:

The invention relates to chem. compounds of formula I and complexes that can be used in therapeutic and diagnostic applications. Compounds of formula I wherein B1, B2, B3 and B4 are independently N, C, B, Si and P; F1 and F2 are independently H, (un)substituted alkyl, (un)substituted heteroaryl, (un)substituted aryl, etc.; L1 – L9 are independently (un)substituted alkyl, (un)substituted heteroalkyl, (un)substituted aryl, etc.; A1, A2, A3 and A4 are independently substituted aryl and (un)substituted heteroaryl; are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their metal chelation ability for use in therapeutic and diagnostic application (some data given). The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Product Details of 170235-18-4

The Article related to dimacrocycle preparation complex therapeutic and diagnostic application, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Product Details of 170235-18-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kelly, T. Ross et al. published their research in Journal of Organic Chemistry in 1996 |CAS: 170235-18-4

The Article related to sulfomycinamate preparation, oxazole triflate preparation coupling reaction, pyridyl triflate preparation coupling thiazole, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Safety of Methyl 6-bromo-5-methoxypicolinate

On July 12, 1996, Kelly, T. Ross; Lang, Fengrui published an article.Safety of Methyl 6-bromo-5-methoxypicolinate The title of the article was Total Synthesis of Dimethyl Sulfomycinamate. And the article contained the following:

Di-Me sulfomycinamate, a methanolysis product from the natural antibiotic sulfomycin I, is synthesized in 11 steps. The chem. of various pyridine, thiazole, and oxazole heterocycles and their coupling reactions under palladium catalysis are examined The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions on a doubly-activated pyridine and the condensation reaction between bromo ketone and amide to form the oxazole moiety. The first preparation of oxazole triflates is described, as is some of their chem. properties. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Safety of Methyl 6-bromo-5-methoxypicolinate

The Article related to sulfomycinamate preparation, oxazole triflate preparation coupling reaction, pyridyl triflate preparation coupling thiazole, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Safety of Methyl 6-bromo-5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kelly, T. Ross et al. published their research in Tetrahedron Letters in 1995 |CAS: 170235-18-4

The Article related to sulfomycinamate total synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Quality Control of Methyl 6-bromo-5-methoxypicolinate

On July 24, 1995, Kelly, T. Ross; Lang, Fengrui published an article.Quality Control of Methyl 6-bromo-5-methoxypicolinate The title of the article was Total synthesis of dimethyl sulfomycinamate. And the article contained the following:

The first total synthesis of di-Me sulfomycinamate is described. Highlights of the synthesis include a selective palladium-catalyzed coupling reaction on a bromo triflate, and a condensation reaction to form the oxazole ring. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Quality Control of Methyl 6-bromo-5-methoxypicolinate

The Article related to sulfomycinamate total synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Quality Control of Methyl 6-bromo-5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Magda, Darren et al. published their patent in 2014 |CAS: 170235-18-4

The Article related to dimacrocycle preparation complex therapeutic and diagnostic application, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Product Details of 170235-18-4

On May 22, 2014, Magda, Darren; Xu, Jide; Butlin, Nathaniel G. published a patent.Product Details of 170235-18-4 The title of the patent was Preparation of di-macrocycles and their complexes for use in therapeutics and diagnostic applications. And the patent contained the following:

The invention relates to chem. compounds of formula I and complexes that can be used in therapeutic and diagnostic applications. Compounds of formula I wherein B1, B2, B3 and B4 are independently N, C, B, Si and P; F1 and F2 are independently H, (un)substituted alkyl, (un)substituted heteroaryl, (un)substituted aryl, etc.; L1 – L9 are independently (un)substituted alkyl, (un)substituted heteroalkyl, (un)substituted aryl, etc.; A1, A2, A3 and A4 are independently substituted aryl and (un)substituted heteroaryl; are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their metal chelation ability for use in therapeutic and diagnostic application (some data given). The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Product Details of 170235-18-4

The Article related to dimacrocycle preparation complex therapeutic and diagnostic application, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Product Details of 170235-18-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: Methyl 6-bromo-5-methoxypicolinate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,170235-18-4, its application will become more common.

Related Products of 170235-18-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 170235-18-4 as follows.

(1) 3-(trifluoromethyl) phenol (1.317 g, 0.0081 mol) was dissolved in 10 ml of dried dimethyl acetamide. While cooling the obtained solution with water, sodium hydride (0.39 g (ca. 60% in mineral oil), 0.0081*1.2 mol) was added to the solution. After completion of the foaming, a solution obtained by dissolving 6-bromo-5-methoxy-2-pyridine carboxylic acid methyl ester (2.0 g, 0.0081 mol) in 10 ml of dried dimethyl acetamide, and then copper iodide (1.55 g, 0.081 mol) were successively added to the solution. The obtained mixture was heated and stirred at 120 C. for 10 hours. Thereafter, the obtained reaction solution was cooled, mixed with 50 ml of water and then with 50 ml of ethyl acetate, and filtered through a glass filter provided with Hyflo Super-Cell. The obtained filtrate was extracted with ethyl acetate to obtain an aimed product. An organic phase was separated from the product, washed with water and then dried with anhydrous sodium sulfate. The dried product was concentrated, and the obtained residues were purified by silica gel column chromatography (eluding solution: ethyl acetate/hexane). Yield weight: 0.68 g; yield percentage: 26%; solid; melting point: 116 to 118 C.; 1 H-NMR (60 MHz, CDCl3, delta): 3.76(3H, s), 3.86(3H, s), 7.16(1H, d, J=8 Hz), 7.2-7.5(4H, complex), 7.80(1H, d, J=8 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,170235-18-4, its application will become more common.

Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US6159901; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: Methyl 6-bromo-5-methoxypicolinate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,170235-18-4, its application will become more common.

Related Products of 170235-18-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 170235-18-4 as follows.

(1) 3-(trifluoromethyl) phenol (1.317 g, 0.0081 mol) was dissolved in 10 ml of dried dimethyl acetamide. While cooling the obtained solution with water, sodium hydride (0.39 g (ca. 60% in mineral oil), 0.0081*1.2 mol) was added to the solution. After completion of the foaming, a solution obtained by dissolving 6-bromo-5-methoxy-2-pyridine carboxylic acid methyl ester (2.0 g, 0.0081 mol) in 10 ml of dried dimethyl acetamide, and then copper iodide (1.55 g, 0.081 mol) were successively added to the solution. The obtained mixture was heated and stirred at 120 C. for 10 hours. Thereafter, the obtained reaction solution was cooled, mixed with 50 ml of water and then with 50 ml of ethyl acetate, and filtered through a glass filter provided with Hyflo Super-Cell. The obtained filtrate was extracted with ethyl acetate to obtain an aimed product. An organic phase was separated from the product, washed with water and then dried with anhydrous sodium sulfate. The dried product was concentrated, and the obtained residues were purified by silica gel column chromatography (eluding solution: ethyl acetate/hexane). Yield weight: 0.68 g; yield percentage: 26%; solid; melting point: 116 to 118 C.; 1 H-NMR (60 MHz, CDCl3, delta): 3.76(3H, s), 3.86(3H, s), 7.16(1H, d, J=8 Hz), 7.2-7.5(4H, complex), 7.80(1H, d, J=8 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,170235-18-4, its application will become more common.

Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US6159901; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem