Category: 170886-13-2

Reference of 170886-13-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 170886-13-2, name is 2-(Trifluoromethyl)pyridin-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

An alternative synthetic process is provided: A mixture of 2-(trifluoromethyl)pyridin-4-ol (5 g, 30.7 mmol), 3,4-difluorobenzaldehyde (4.36 g, 30.7 mmol) and potassium carbonate (8.47 g, 61.3 mmol) in Nu,Nu-dimethylformamide (DMF) (30 mL) was sealed and heated under microwave at 110 C for 3 h. Then the reaction mixture was cooled, and concentrated in vacuo. The concentrate was purified via Biotage column (Hexane/EtOAc 100% to 3/1) to afford the title compound (6.4 g, 37.6%) as a white solid. LCMS (ESI): m/z 286 [M + H]+; 1.35 min (ret time)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 170886-13-2, 2-(Trifluoromethyl)pyridin-4-ol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; SANG, Yingxia; WAN, Zehong; ZHANG, Qing; WO2014/114694; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 170886-13-2, name is 2-(Trifluoromethyl)pyridin-4-ol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H4F3NO

Example 231 Synthesis of 4-methoxy-2-(trifluoromethyl)pyridine. To a solution of 2-(trifluoromethyl)pyridin-4-ol (5.8 g, 35.56 mmol) in DMF (40 mL) was added iodomethane (11.1 g, 78.23 mmol) and K2CO3 (6.05 g, 43.74 mmol). Then the reaction mixture was stirred at 65 C. for 2 h. The mixture was treated with H2O (100 mL) and extracted with EtOAc (70 mL*3). The combined organic layers were washed with brine, dried over Na2SO4, concentrated to give 4-methoxy-2-(trifluoromethyl)pyridine as a yellow oil (3.5 g, yield: 55%) which was used in next step without further purification. ESI-MS [M+H]+: 178.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 170886-13-2, 2-(Trifluoromethyl)pyridin-4-ol.

Reference:
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 170886-13-2, name is 2-(Trifluoromethyl)pyridin-4-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C6H4F3NO

An alternative synthetic procedure is provided: 3,4,5-trifluorobenzaldehyde (1.08 g, 6.74 mmol) was added to a solution of 2-trifluoromethyl)pyridin-4-ol (1 g, 6.13 mmol) and potassium carbonate (1.017 g, 7.36 mmol) in Nu,Nu-dimethylformamide (DMF) (10 mL) under nitrogen with stirring. The reaction mixture was stirred at 100 C for 16 h, cooled to rt, and then diluted with EtOAc (30 mL) and water (30 mL). The organic phase was washed three times with water (30 mL), dried over sodium sulphate, and then concentrated in vacuo to afford the title compound (1.8 g, 97%). LCMS (ESI): m/z 304 [M + H]+; 1.17 min (ret time)

The synthetic route of 170886-13-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; SANG, Yingxia; WAN, Zehong; ZHANG, Qing; WO2014/114694; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 170886-13-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 170886-13-2, name is 2-(Trifluoromethyl)pyridin-4-ol. A new synthetic method of this compound is introduced below.

A mixture of 2-(trifluoromethyl)pyridin-4-ol (100 mg, 0.613 mmol) and Lawesson?s reagent (123.99 mg, 0.307 mmol) in toluene (10 mL) was refluxed for 2 hours. Excess solvent was evaporated under reduced pressure. The residue was purified by automate column chromatography to give the desired product (75 mg, 68% yield). LC-MS: m/z: 180 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,170886-13-2, 2-(Trifluoromethyl)pyridin-4-ol, and friends who are interested can also refer to it.

Reference:
Patent; HELMHOLTZ-ZENTRUM FUeR INFEKTIONSFORSCHUNG GMBH; AHMED, Ahmed S. A.; EMPTING, Martin; HAMED, Mostafa; HARTMANN, Rolf W.; HAUPENTHAL, Joerg; HASTERKAMP, Thomas; KAMAL, Ahmed A. M.; MAURER, Christine K.; ROeHRIG, Teresa; SCHUeTZ, Christian; YAHIAOUI, Samir; ZENDER, Michael; (128 pag.)WO2020/7938; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 170886-13-2 as follows., 170886-13-2

Starting material 8d 5-Iodo-2-(trifluoromethyl)pyridin-4-ol:A 250 mL round bottom flask was charged 2-(trifluoromethyl)pyridin-4-ol (prepared as described in Tyvorskii, V. I., Bobrov, D. N. Chemistry of Heterocyclic Compounds 1997, 33, 1138-9; 42.7 mmol). MeOH (45 mL) was added, and the solution was cooled to 0 0C. Potassium carbonate (6.55 g, 47.4 mmol) was added, and the resulting mixture was treated with iodine (11.37 g, 44.8 mmol) in portions over 5 minutes. The resulting mixture was allowed to stir at 0 0C, with slow warming to room temperature. After stirring at room temperature overnight, the reaction was quenched with aqueous NaS2theta3, was acidifed withHOAc (10 mL), and was extracted with EtOAc (4x). The combined organics were washed with brine, concentrated, and purified by silica gel chromatography (gradient elution; Rf in70:30 hexanes:EtOAc = 0.30) to give a pale yellow solid (2.74 g, 22%) of -90% purity. M/Z = 288. 1H NMR (400 MHz, DMSO-D6) delta ppm 7.19 (m, 1 H) 8.80 (m, 1 H) 12.43 (s, 1 H).

The chemical industry reduces the impact on the environment during synthesis 170886-13-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/59238; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem