Category: 171178-21-5

Application of 171178-21-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 171178-21-5 as follows.

6-Chloro-3-nitropicolinamide, 4.80 g (23.8 mmol), and palladium carbon (10%), 0.67 g (6.3 mmol), were added into 60 ml_ of ethyl acetate. The resulting mixture was stirred under hydrogen atmosphere (2 atm) for 3 hours at room temperature. Then palladium on carbon was filtered out and washed with ethyl acetate. The solvent was removed in vacuo to give 3.79 g (89%) of the product as a yellow solid. MS (ESIpos): m/z = 172 (M+H)+; LC-MS (Method 4, Acetonitrile-Water-0.1 % FA-10%B): Rt = 0.59 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,171178-21-5, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAYER HEALTHCARE CHINA; WORTMANN, Lars; SAUTIER, Brice; EIS, Knut; BRIEM, Hans; BOeHNKE, Niels; VON NUSSBAUM, Franz; HILIG, Roman; BADER, Benjamin; SCHROeDER, Jens; PETERSEN, Kirstin; LIENAU, Philip; WENGNER, Antje, Margret; MOOSMAYER, Dieter; WANG, Qiuwen; (278 pag.)WO2019/201848; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 171178-21-5, Adding some certain compound to certain chemical reactions, such as: 171178-21-5, name is 6-Chloro-3-nitropicolinamide,molecular formula is C6H4ClN3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 171178-21-5.

To a solution of 700 mg (2.1 mmol) of Intermediate 2 and 770 mg (4.2 mmol) of 6- chloro-3-nitropyridine-2-carboxamide (prepared as in G. W. Rewcastle, et. al. J. Med. Chem. 1996, 39, 1823-1835) in 8 mL of toluene and 4 mL of NN-dimethylformamide was added 1.7 mL (10.6 mmol) of N,N-diisopropylethylamine and the solution was stirred under nitrogen at reflux for 30 h. The reaction mixture was then cooled to ambient temperature, diluted with 15 mL of methylene chloride and poured into 100 mL of a saturated aqueous bicarbonate solution. The layers were separated and the aqueous layer extracted with three 100 mL portions of methylene chloride and the combined organic phases were dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to yield a yellow solid. The yellow solid was purified by flash chromatography on a Biotage Horizon system (silica gel, 0 to 70% ethyl acetate/hexanes gradient) to give the title compound as a yellow crystalline solid. LC/MS 496.6 (M+l).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 171178-21-5, 6-Chloro-3-nitropicolinamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2006/39325; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem