Category: 17228-64-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17228-64-7, name is 2-Chloro-6-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 17228-64-7

General procedure: A heating reaction vessel was charged with the prescribed amount of catalyst, naphthylpyrimidine (0.5 mmol), aryl chloride (0.6 mmol), K2CO3 (1.5 mmol), KO2CR (0.1 mmol), PAr3 (0.1 mmol) and water (3 mL) under nitrogen. The vessel was sealed and heated at 120 C (oil bath temperature) for 24 h. The resulting mixture was cooled to room temperature, and the aqueous layer was extracted with ethyl acetate, then the combined organic layers were washed with water, dried over MgSO4, filtered, and the solvent was removed on a rotary evaporator. The resulting residue was purified by flash chromatography to give the corresponding products 1-34.

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Reference:
Article; Li, Hong-Mei; Tu, Tian-Yong; Han, Xin; Wang, Zhi-Qiang; Fu, Wei-Jun; Hao, Xin-Qi; Song, Mao-Ping; Xu, Chen; Synlett; vol. 29; 13; (2018); p. 1729 – 1734;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17228-64-7 ,Some common heterocyclic compound, 17228-64-7, molecular formula is C6H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Under Nitrogen, to a 10 mL Schlenk flask equipped with a magnetic bar, potassium hydroxide (4.5 mmol, 252 mg), phenyl boronic acid (3.15 mmol), and aryl chlorides (3 mmol) (if liquid, was injected through the septum later), catalyst 3 (0.05 mol% catalyst loading, 1 mg) were added in turn, followed by addition of 2-propanol (5 mL) and H2O (0.5 mL). The mixture was then stirred at 80 for 2 h. It was also monitored by gas chromatography. Water was added to the reaction mixture, which was extracted by ethyl acetate, dried over anhydrous Na2SO4, and the solvent was evaporated in vacuum. When necessary the product was purified by flash chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17228-64-7, 2-Chloro-6-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shen, An; Hu, Yu-Cai; Liu, Ting-Ting; Ni, Chen; Luo, Yong; Cao, Yu-Cai; Tetrahedron Letters; vol. 57; 19; (2016); p. 2055 – 2058;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 17228-64-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17228-64-7, name is 2-Chloro-6-methoxypyridine, molecular formula is C6H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the solution of Compound 57 (10.0 g, 69.6 mmol, 1.00 eq) in THF (200 mL) andNMP (20.0 mL) was added Fe(acac)3 (1.23 g, 3.48 mmol, 0.05 eq). Then i-PrMgC1 (2 M, 41.79 mL, 1.20 eq) was added dropwise at -30 C within 30 mm. The mixture was stirred at 0 C for 1 h. The reaction mixture was quenched with saturated aqueous NH4C1 (80 mL) at 0 C. Then the two phases were separated and the aqueous phase was extracted with methyl t-butyl ether (80 mL). The combined organic phases were washed with water (4 x 50 mL). Then the organic phase was dried over anhydrous Na2504, filtered and concentrated to give compound 58 (7.10 g, 46.9 mmol, 67% yield) as a yellow liquid which was used for the next step without purification.?H NMR (400MHz, Chloroform-d) oe = 7.48 (t, J 7.7 Hz, 1H), 6.72 (d, J 7.1 Hz, 1H), 6.54 (d, J 7.9 Hz, 1H), 3.93 (s, 3H), 2.95 (td, J 6.8, 13.7 Hz, 1H), 1.28 (d, J= 7.1 Hz, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17228-64-7, 2-Chloro-6-methoxypyridine.

Reference:
Patent; AFFERENT PHARMACEUTICALS INC.; HAWLEY, Ronald Charles; IBRAHIM, Prabha; FORD, Anthony, P.; GEVER, Joel, R.; (171 pag.)WO2017/160569; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 17228-64-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17228-64-7, name is 2-Chloro-6-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.

To a stirred solution of 9(7.00 g, 48.8 mmol) in CH3CN (25 mL) was added NBS (13.0 g, 73.1 mmol) at room temperature. The resulting mixture was refluxed for 24 h. Then the reaction was quenched with saturated aqueous Na2S2O3and extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, n-hexane-EtOAc=98 : 2) to afford methoxypyridine 31(6.83 g, 63%) as a colorless solid.31: mp 64-65C; IR (film, cm-1): 1584, 1551, 1466, 1408, 1344, 1306, 1256, 1155, 1121, 1022, 1009; 1H-NMR (CDCl3, 500 MHz) delta: 7.72 (d, J=8.50 Hz, 1H), 6.58 (d, J=8.50 Hz, 1H), 3.92 (s, 3H); 13C-NMR (CDCl3, 125 MHz) delta: 162.4, 147.3, 143.8, 110.9, 110.1, 54.3; HR-MS (ESI-TOF): Calcd for C6H6BrClNO [(M+H)+] 221.9316. Found 221.9314.

Statistics shows that 17228-64-7 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-6-methoxypyridine.

Reference:
Article; Inai, Makoto; Ouchi, Hitoshi; Asahina, Aya; Asakawa, Tomohiro; Hamashima, Yoshitaka; Kan, Toshiyuki; Chemical and Pharmaceutical Bulletin; vol. 64; 7; (2016); p. 723 – 732;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17228-64-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17228-64-7, name is 2-Chloro-6-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

An oven dried threaded 2 dram, 17*60 mm reaction vial equipped with a Teflon-coated magnetic stir bar is charged with [(pi-allyl)Pd(Bippyphos)]OTf (16 mg, 0.02 mmol, 2 mol %), BippyPhos (10 mg, 0.02 mmol, 2 mol %), 2-phenylindole (193 mg, 1.00 mmol), and NaOt-Bu (135 mg, 1.40 mmol). The vial is capped with a polypropylene cap with PTFE-faced silicone septum and is evacuated and backfilled with nitrogen. This evacuation/backfill cycle is repeated two additional times. Anhydrous toluene (4 mL) and 2-chloro-6-methoxypyridine (119 muL, 1.00 mmol) are added sequentially via syringe. The nitrogen needle is removed and the vial is placed on a preheated aluminum block (110 C.) and stirred for 16 hours. The tube is then removed from the heating block and allowed to cool to room temperature. The reaction mixture is diluted with 10 mL of EtOAc, filtered through a pad of Celite, and concentrated in vacuo. The residue is chromatographed on silica gel using a Teledyne ISCO CombiFlashRf with a gradient of 0-5% EtOAc/hexanes as the eluent to give 293 mg (0.98 mmol, 98%) of 1-(6-methoxypyridin-2-yl)-2-phenyl-1H-indole as a colorless oil. 1H NMR (400 MHz, CDCl3, delta): 7.75 (d, J=7.8 Hz, 1H), 7.69 (d, J=7.8 Hz, 1H), 7.55 (t, J=7.8 Hz, 1H), 7.31-7.20 (m, 7H), 6.80 (s, 1H), 6.67-6.62 (m, 2H), 3.76 (s, 3H). 13C NMR (100 MHz, CDCl3, delta): 163.7, 149.6, 140.6, 140.1, 138.4, 133.5, 129.0, 128.9, 128.3, 127.5, 123.0, 121.5, 120.8, 113.6, 111.7, 108.6, 105.6, 53.8.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17228-64-7, 2-Chloro-6-methoxypyridine.

Reference:
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas; Jon Deangelis, Andrew; (66 pag.)US9777030; (2017); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem