Category: 17281-59-3

A new synthesis of 3,4-diaminothiophenes was written by Tominaga, Yoshinori;Fujito, Hiroshi;Matsuda, Yoshiro;Kobayashi, Goro. And the article was included in Heterocycles in 1977.SDS of cas: 17281-59-3 This article mentions the following:

Thiophenediamines I (R = CN, CONH₂, CO₂Et, Bz) were prepared by treating R¹CH₂CNCl^– (R¹ = pyridinio) with CS₂-NaOH, treating R¹C(CN):C(SNa)S^– with R²CH₂R (R² = Cl, Br), cyclizing R¹C(CN):C(S^–)SCH₂R with NEt₃, methylating ylides II (R³ = S^–), treating II (R³ = SMe) with MeNH₂-HCl and neutralizing. I condensed with R⁴COCOR⁴ (R⁴ = H, Me, Ph) to give the thienopyrazines III. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3SDS of cas: 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cytotoxicity estimation of ionic liquids based on their effective structural features was written by Fatemi, Mohammad H.;Izadiyan, Parisa. And the article was included in Chemosphere in 2011.Product Details of 17281-59-3 This article mentions the following:

Cytotoxicity of a diverse set of 227 ionic liquids (taken from UFT/Merck Ionic Liquids Biol. Effects Database) containing 94 imidazolium, 53 pyridinium, 23 pyrrolidinium, 22 ammonium, 15 piperidinium, 10 morpholinium, 5 phosphanium, and 5 quinolinium cations in combination with 25 different types of anions to Leukemia Rat Cell Line (IPC-81) was estimated from their structural parameters using quant. structure – toxicity relationship “QSTR” methodol. Linear and nonlinear models were developed using genetic algorithm (GA), multiple linear regressions (MLR) and multilayer perceptron neural network (MLP NN) approaches. Robustness and reliability of the constructed models were evaluated through internal and external validation methods. Furthermore, chem. applicability domain was determined via leverage approach. In this work, it was revealed that the cationic moieties make the major contribution to cytotoxicity and the anionic parts play a secondary role in cytotoxicity of the ionic liquids studied here. Structural information represented in this work, can be used for a rational design of safer ILs. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Product Details of 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation of new nitrogen-bridged heterocycles. 42. Synthesis and the reaction of pyridinium N-ylides using bifunctional ethyl thiocyanatoacetates was written by Kakehi, Akikazu;Ito, Suketaka;Hashimoto, Yasunobu. And the article was included in Bulletin of the Chemical Society of Japan in 1996.Formula: C7H7ClN2 This article mentions the following:

Various pyridinium (monosubstituted methylide)s I (R², R³, R⁴ = H, Me; R⁵ = cyano, CO₂Et, COMe, COPh) were smoothly attached to the cyano group in Et thiocyanatoacetate or Et 2-thiocyanatopropionate to afford the corresponding pyridinium (substituted cyanomethylide)s II in low-to-moderate yields, while pyridinium (unsubstituted amidate)s III (R¹, R², R³ = H, Me) reacted with the ester carbonyl group in the same reagents to give pyridinium (thiocyanatoacetato)- or (2-thiocyanatopropiono)amidates IV in considerable yields. The 1,3-dipolar cycloadditions of some pyridinium (unsym. substituted cyanomethylide)s with di-Me acetylenedicarboxylate (DMAD) in various solvents afforded only di-Me 3-cyanoindolizine-1,2-dicarboxylate, except for a few examples. On the other hand, the treatment of pyridinium (thiocyanatoaceto)- or (2-thiocyanatopropiono)amidates with a strong base, such as potassium tert-butoxide, gave new bicyclic mesoionic compounds, N-[2-(1,3,4-thiadiazolo[3,2-a]pyridinio)]acetamidate derivatives V, in moderate yields. The intermediacy of N-[1-(2-thiocyanatopyridinio)]acetamidates in the formation reactions of the latter compounds was also proven by independent syntheses. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A convenient synthesis of perfluoroalkylated indolizinylphosphonates was written by Shen, Yanchang;Zhang, Yuming;Jiang, Guo-Fang. And the article was included in Synthesis in 2002.HPLC of Formula: 17281-59-3 This article mentions the following:

A convenient method for the synthesis of perfluoroalkylated indolizinylphosphonates via the 1,3-cycloaddition of pyridinium N-ylides and perfluoroalkynylphosphonates in 49-77% yields is described. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3HPLC of Formula: 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.HPLC of Formula: 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis in the 4-azafluorene group. Part III was written by Chatterjea, J. N.;Shaw, S. C.;Singh, S. N.. And the article was included in Journal of the Indian Chemical Society in 1978.Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride This article mentions the following:

Cyclocondensation of benzylideneindandiones I (R = H, Me, MeO, NO₂) with NH₄OAc in the presence of 1-phenacylpyridinium bromide gave the diindenopyridines II. Hantzsch cyclization of 2-benzylidene-1-indanone with PhC(NH₂):CCN gave the dihydroazafluorenone III, which was aromatized by chromic acid, hydrolyzed, and decarboxylated to give the azafluorenone IV (Z = O). Wolff-Kishner reduction of IV (Z = O) gave IV (Z = H₂). Treatment of 2-benzylideneindan-1-one with NH₄OAc and 1-acetonylpyridinium bromide gave 3-methyl-1-phenyl-4-azafluorene, which was also obtained from Et 3-methyl-1-phenyl-4-azafluorenone-2-carboxylate by successive hydrolysis, decarboxylation, and Wolff-Kishner reduction 1-Benzylidene-2-indanone was prepared from Et 3-benzylidene-2-oxo-1-indancarboxylate by hydrolysis-decarboxylation. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective synthesis of some imidazopyridine-fused chromones was written by Costa, Marta;Proenca, M. Fernanda. And the article was included in Tetrahedron in 2011.Formula: C7H7ClN2 This article mentions the following:

A fused heterocyclic scaffold combining the imidazo[1,2-a]pyridine with a substituted chromone was synthesized in a one-pot procedure. The reaction proceeds by intramol. cyclization of 1-(2-imino-2H-chromen-3-yl)pyridinium chloride in ethanol and in the presence of DABCO. A detailed study of the exptl. conditions allowed a clear understanding of the reaction pathway. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and reaction of 3,4-diaminothiophenes was written by Tominaga, Yoshinori;Fujito, Hiroshi;Norisue, Hajime;Ushirogochi, Atsuyuki;Matsuda, Yoshiro;Kobayashi, Goro. And the article was included in Yakugaku Zasshi in 1979.SDS of cas: 17281-59-3 This article mentions the following:

Addition of pyridinium chloride I and CS₂ gave Ia, which was alkylated by XCH₂Y (X = Cl, Br; Y = CN, CO₂Et, Bz, CONH₂), cyclized, and iodomethylated to give II (R¹ = CN, CO₂Et, Bz, CONH₂; R² = pyridinio iodide). Cleavage of II iodide by addition of MeNH₂ followed by cyclization, acid hydrolysis, and neutralization gave II (R¹ = CN, CO₂Et, Bz, CONH₂; R² = NH₂). Also prepared were thieno[3,2-d]pyrimidinones III (R³ = Me, Ph; R⁴ = NH₂, NHBz, pyridinio chloride) and the thieno[3′,4′:4,5]imidazo[1,2-a]pyridine IV. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3SDS of cas: 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Equilibrium acidities and homolytic bond dissociation energies of the acidic carbon-hydrogen bonds in N-substituted trimethylammonium and pyridinium cations was written by Zhang, Xian Man;Bordwell, Frederick G.;Van Der Puy, Michael;Fried, Herbert E.. And the article was included in Journal of Organic Chemistry in 1993.Related Products of 17281-59-3 This article mentions the following:

Equilibrium acidities (pK_HA) of the cations in 16 N-substituted trimethylammonium salts, one N-phenacylquinuclidinium salt, 8 N-substituted pyridinium salts, and N-(ethoxycarbonyl)isoquinolinium bromide, together with the oxidation potentials of their conjugate bases, have been determined in Me₂SO. The acidifying effects of the α-trimethylammonium groups (α-Me₃N⁺) and the α-pyridinium groups (α-PyN⁺) on the adjacent acidic C-H bonds in these cations were found to average about 10 and 18 pK_HA units, resp. The homolytic bond dissociation energies of the acidic C-H bonds in these cations, estimated by the combination of the equilibrium acidities with the oxidation potentials of their corresponding conjugate bases (ylides), show that the α-trimethylammonium groups destabilize adjacent radicals by 2-6 kcal/mol, whereas α-pyridinium groups stabilize adjacent radicals by 3-6 kcal/mol. The effects of α-pyridinium groups on the stabilization energies of the radicals derived from these cations were ca. 4-10 kcal/mol smaller than those of the corresponding Ph groups, whereas their effects on the equilibrium acidities of the cations were 5.4-13.1 pK_HA units larger. The pK_HA value of tetramethylammonium cation (Me₄N⁺) was estimated by extrapolation to be about 42 in Me₂SO. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Related Products of 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Predictive in silico Modeling of Ionic Liquids toward Inhibition of the Acetyl Cholinesterase Enzyme of Electrophorus electricus: A Predictive Toxicology Approach was written by Das, Rudra Narayan;Roy, Kunal. And the article was included in Industrial & Engineering Chemistry Research in 2014.Related Products of 17281-59-3 This article mentions the following:

Chems. are the essential components of the industry for maneuvering the required need of the living ecosystem. Ionic liquids are a group of promising novel chems. with potential usefulness toward various industrial applications, although they are not entirely devoid of hazardous outcomes. The present study is an attempt to investigate the chem. attributes of a wide variety of 292 ionic liquids toward their inhibitory potential of acetyl cholinesterase enzyme of elec. eel through the development of predictive regression and classification-based quant. math. models in the light of the OECD guidelines. Mol. docking studies have addnl. corroborated the results. Hydrophilicity, hydrophobicity, branching, and pos. charged N-species were observed to be the major chem. contributors to such toxicity. The docking studies chiefly portrayed the π-cationic type interaction of the cationic N⁺ atom with the Phe 288, Phe 290, and Trp 23 residues of the acyl binding pocket to be responsible for enzyme inhibition. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Related Products of 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation of new nitrogen-bridged heterocycles. 72. A new approach to 1-acyl-3-(substituted methylthio)thieno[3′,4′:4,5]imidazo[1,5-a]pyridine derivatives was written by Kakehi, Akikazu;Suga, Hiroyuki;Okumura, Yukihisa;Itoh, Kennosuke;Kobayashi, Kouji;Aikawa, Yoshihiro;Misawa, Kotaro. And the article was included in Chemical & Pharmaceutical Bulletin in 2010.Recommanded Product: 17281-59-3 This article mentions the following:

The alk. treatment of the pyridinium salts, readily available from the S-alkylation of 3-amino-4-(1-pyridinio)thiophene-5-thiolates with various alkyl halides, in chloroform at room temperature afforded the corresponding thieno[3′,4′:4,5]imidazo[1,2-a]pyridine derivatives, e.g., I (R = Ph, 4-ClC₆H₄, OEt, etc., R⁴ = H, Me, PhCH₂, Ph, etc.), in low to moderate yields via the intramol. cyclization of the resulting 1,5-dipoles followed by the aromatization of the primary cycloadducts. Interestingly, the reactions using unsym. 3-amino-4-[1-(3-methylpyridinio)]thiophene-5-thiolates afforded only 8-methylthieno[3′,4′:4,5]imidazo[1,2-a]pyridines and the other 6-Me derivatives were not formed at all. In addition, the isolation of a byproduct in the condensation reaction of pyridinium salt with the solvent (CHCl₃) is also discussed. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Recommanded Product: 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem