Category: 17281-59-3

Liu, Juanjuan published the artcileIodine-promoted synthesis of acylindolizine derivatives from acetylenecarboxylates and pyridinium, isoquinolinium, or quinolinium ylides, Category: pyridine-derivatives, the publication is Monatshefte fuer Chemie (2014), 145(4), 617-625, database is CAplus.

An iodine-promoted synthesis of acylindolizinecarboxylates via 1,3-dipolar cycloaddition of nitrogen ylides with acetylenecarboxylates and subsequent aromatization for the generation of a wide range of structurally interesting, pharmacol. and photoelec. significant compounds is reported. Only readily available materials, mild conditions, and operationally trivial reaction protocols were required.

Monatshefte fuer Chemie published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yan, Fangyou published the artcilePredicting Toxicity of Ionic Liquids in Acetylcholinesterase Enzyme by the Quantitative Structure-Activity Relationship Method Using Topological Indexes, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Journal of Chemical & Engineering Data (2012), 57(8), 2252-2257, database is CAplus.

A new topol. index (TI) was proposed based on atom characters (e.g., atom radius, atom electronegativity, etc.) and atom positions in the hydrogen-suppressed mol. structure in our previous work. In this work, the TI was used for predicting the toxicity of ILs in acetylcholin esterase (log EC₅₀ AChE) by the multiple linear regression (MLR) method. For ILs composed entirely of cations and anions, the TIs are calculated from cations and anions, resp. The 221 ILs used in the MLR model are based on imidazolium (Im), pyridinium (Pyi), pyrrolidinium (Pyo), ammonium (Am), phosphonium (Ph), quinolinium (Qu), piperidinium (Pi), and morpholinium (Mo). The regression coefficient (R²) and the overall average absolute error (AAE) are 0.877 and 0.153, resp.

Journal of Chemical & Engineering Data published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C20H19NO4, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fang, Xiang published the artcileSynthesis of monofluorinated indolizines and their derivatives by the 1,3-dipolar reaction of N-ylides with fluorinated vinyl tosylates, COA of Formula: C7H7ClN2, the publication is Tetrahedron (2004), 60(25), 5487-5493, database is CAplus.

Monofluorinated indolizines, benzo[d]indolizines and 4H-pyrrolo[1,2-a]benzimidazoles were synthesized in moderate yields by 1,3-dipolar cycloaddition reaction between fluorinated vinyl tosylates and N-ylides of pyridinium, isoquinolinium and benzimidazolium, generated in situ from their halide salts. When the same N-ylides were allowed to react with 2,3,3-trifluoro-1-propenyl tosylate, the unexpected product formylated indolizines and their derivatives, e.g., I, were obtained. A reaction mechanism is also proposed.

Tetrahedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, COA of Formula: C7H7ClN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Banks, Ronald Eric published the artcileFluorocarbon derivatives of nitrogen. Part 11. Synthesis of some 2-(trifluoromethyl)imidazo[1,2-a]pyridines from trifluoroacetonitrile, Related Products of pyridine-derivatives, the publication is Journal of Fluorine Chemistry (1984), 26(4), 499-506, database is CAplus.

The title compound (I; R = Me₃CO₂C), prepared from CF₃CN and pyridinium t-butoxycarbonylmethylide, reacts smoothly with CF₃CO₂H to give the acid (I; R = HO₂C), which was decarboxylated to I (R = H) on heating. The cyano derivative (I; R = cyano) can be obtained via treatment of CF₃CN with pyridinium cyanomethylide, which is sufficiently reactive to effect nucleophilic displacement of fluorine from pentafluoropyridine under mild conditions to give II.

Journal of Fluorine Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kakehi, Akikazu published the artcilePreparation of new nitrogen-bridged heterocycles. 72. A new approach to 1-acyl-3-(substituted methylthio)thieno[3′,4′:4,5]imidazo[1,5-a]pyridine derivatives, HPLC of Formula: 17281-59-3, the publication is Chemical & Pharmaceutical Bulletin (2010), 58(11), 1502-1510, database is CAplus and MEDLINE.

The alk. treatment of the pyridinium salts, readily available from the S-alkylation of 3-amino-4-(1-pyridinio)thiophene-5-thiolates with various alkyl halides, in chloroform at room temperature afforded the corresponding thieno[3′,4′:4,5]imidazo[1,2-a]pyridine derivatives, e.g., I (R = Ph, 4-ClC₆H₄, OEt, etc., R⁴ = H, Me, PhCH₂, Ph, etc.), in low to moderate yields via the intramol. cyclization of the resulting 1,5-dipoles followed by the aromatization of the primary cycloadducts. Interestingly, the reactions using unsym. 3-amino-4-[1-(3-methylpyridinio)]thiophene-5-thiolates afforded only 8-methylthieno[3′,4′:4,5]imidazo[1,2-a]pyridines and the other 6-Me derivatives were not formed at all. In addition, the isolation of a byproduct in the condensation reaction of pyridinium salt with the solvent (CHCl₃) is also discussed.

Chemical & Pharmaceutical Bulletin published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, HPLC of Formula: 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kakehi, Akikazu published the artcilePreparation of new nitrogen-bridged heterocycles. 60. Syntheses and conformational analyses of bis(indolizin-1-yl) disulfides, HPLC of Formula: 17281-59-3, the publication is Chemical & Pharmaceutical Bulletin (2007), 55(10), 1458-1465, database is CAplus and MEDLINE.

Bis(indolizin-1-yl) disulfides I (R = cyano, CO₂Et, COPh, R¹ = Me, Et, CH₂Ph, etc., R² = H, Me), readily obtainable from the treatment of 1-(benzoylthio)indolizines II with piperidine, were prepared and their conformations were investigated. In comparison with those of 1-(benzoylthio)indolizines, the ¹H-NMR spectra of these disulfides showed considerable high field shifts (δ 0.13-0.82 ppm) on each pyridine ring proton and the UV spectra exhibited significant bathochromic and hyperchromic shifts. These results supported strongly the participation of an intramol. π-π interaction between two indolizine rings in these mols. and, hence, of a particular gauche (cis) conformation. However, the conformational considerations and mol. calculations (Mopac PM3) for some bis(indolizin-1-yl) disulfides showed the presence of four more stable gauche forms in which two are enantiomeric, resulting in three types of gauche structures. These three types of gauche structures were confirmed by X-ray analyses.

Chemical & Pharmaceutical Bulletin published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, HPLC of Formula: 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Arning, Juergen published the artcileQualitative and quantitative structure activity relationships for the inhibitory effects of cationic head groups, functionalized side chains and anions of ionic liquids on acetylcholinesterase, Quality Control of 17281-59-3, the publication is Green Chemistry (2008), 10(1), 47-58, database is CAplus.

To contribute to a deeper insight into the hazard potential of ionic liquids to humans and the environment, an acetylcholinesterase (AchE) inhibition screening assay was used to identify toxicophore substructures and interaction potentials mediating enzyme inhibition. The pos. charged nitrogen atom, a widely delocalized aromatic system, and the lipophilicity of the side chains connected to the cationic head groups can be identified as the key structural elements in binding to the enzymes active site. With respect to this, the dimethylaminopyridinium, the quinolinium and the pyridinium head groups exhibit a very strong inhibitory potential to the enzyme with IC₅₀ values around 10 μM. In contrast, the polar and non-aromatic morpholinium head group is found to be only weakly inhibiting to the enzyme activity, with IC₅₀ values > 500 μM. The introduction of polar hydroxy, ether or nitrile functions into the alkyl side chain is shown to be a potent structural alteration to shift the corresponding ionic liquids to a lower inhibitory potential. Supporting this fact, for a series of imidazolium cations, a QSAR correlation was set up by the linear regression of the log IC₅₀ vs. the logarithm of the HPLC-derived lipophilicity parameter k₀. Addnl., a broad set of anion species (inorganic, organic and complex borate anions), commonly used as ionic liquid counterions, was tested and the vast majority exhibited no effect on AchE. Only the fluoride and fluoride containing anion species which readily undergo hydrolytic cleavage can be identified to act as AchE inhibitors.

Green Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Quality Control of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Neumann, Jennifer published the artcileBiodegradability of 27 pyrrolidinium, morpholinium, piperidinium, imidazolium and pyridinium ionic liquid cations under aerobic conditions, Synthetic Route of 17281-59-3, the publication is Green Chemistry (2014), 16(4), 2174-2184, database is CAplus.

The chem. and thermal stability of ionic liquids (ILs) makes them interesting for a large variety of applications in nearly all areas of the chem. industry. However, this stability is often reflected in their recalcitrance towards biodegradation, which comes with the risk of persistence when they are released into the environment. The authors carried out a systematic study of the biodegradability of pyrrolidinium, morpholinium, piperidinium, imidazolium and pyridinium-based IL cations substituted with different alkyl or functionalized side chains and using halide counterions. The authors examined their primary degradability by specific anal. and/or their ultimate biodegradability using BOD tests according to OECD guideline 301F. Biol. transformation products were studied using mass spectrometry. A comparison of the biodegradation potential of these ILs shows that for all five head groups, representatives can be found that are readily or inherently biodegradable, thus permitting the structural design of ILs with a reduced environmental hazard.

Green Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Synthetic Route of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sugimura, Yukio published the artcileSeven-membered ring compounds. XXXVIII. Reaction of troponoid with ylide. III. Reaction of tropone with pyridinium compounds, Quality Control of 17281-59-3, the publication is Bulletin of the Chemical Society of Japan (1972), 45(10), 3174-8, database is CAplus.

Phenacylpyridinium ylide (I, R = H, Br) reacted with tropone to afford 2-hydroxy-2-phenyl-3-phenacyl-2H-cyclohepta[b]furan (II) which was converted into 2-(1,2-dibenzoylethyl)tropone. The reactions of tropone with several kinds of pyridinium bromides yielded 2-substituted tropones in the presence of amines and 1-azaazulene derivatives including III in a one-step formation in the presence of NH4OAc.

Bulletin of the Chemical Society of Japan published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C3H3Br2ClO, Quality Control of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Reuss, Robert H. published the artcileCyano adducts of 1-substituted pyridinium salts, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Journal of Organic Chemistry (1974), 39(14), 2027-31, database is CAplus.

The preparation and characterization of 10 cyano adducts I (R = 4-pyridyl, CH2OMe, Ph, etc.) from 1-substituted pyridinium salts II (X = Cl, Br) is described. In addition, the first Reissert-like compound (III) from pyridine is reported. I are relatively stable.

Journal of Organic Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem