Category: 17282-03-0

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17282-03-0, name is 3-Bromo-2-chloro-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

Step 131.4: 3-Bromo-2-methoxy-5-methyl-pyridine To a solution of 3-bromo-2-chloro-5-methylpyridine (5 g, 24.2 mmol) in MeOH (80 mL) was added a solution of sodium methoxide 5.4M in MeOH (25 mL, 135 mmol) and the mixture was stirred at 65C for 32 h. The resulting suspension was filtered and the mother liquor was concentrated. Et20 and H20 were added and the phases were separated. The organic layer was washed with H20 and brine, dried (MgS04), filtered and concentrated. The residue was purified by flash chromatography (heptane/EtOAc: 90: 10? 0:100) to afford the title compound. tR: 1.03 min (LC-MS 2).

With the rapid development of chemical substances, we look forward to future research findings about 17282-03-0.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; KALLEN, Joerg; LIAO, Lv; MAH, Robert; MAO, Liang; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea; WO2013/111105; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 17282-03-0 ,Some common heterocyclic compound, 17282-03-0, molecular formula is C6H5BrClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis 53 [5-(2-Chloro-5-methyl-pyridi -3-yl)-thiazol-2-yl]-propyl-carbamic acid tert-butyl ester 3-tert-Butyl-1-propyl-1-[5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-thiazol-2-yl]-urea (1 mmol, 0.37 g) 2-chloro-3-bromo-5-methylpyridine (1 mmol, 0.20 g), potassium carbonate (2 mmol, 0.27 g) and bis(triphenylphosphine) palladium(ll)dichloride (0.050 mmol, 0.035 g) were weighed into a microwave vial and treated with dioxane (1.5 mL) and water (0.5 mL). The reaction mixture was heated at 130 C for 15 minutes in a microwave reactor. The reaction mixture was diluted with water (40 mL), extracted with DCM (2×30 mL) and passed through a phase separation cartridge. The organics were evaporated to a brown oil. This was purified by flash column chromatography 1 :9 ethyl acetate cyclohexane to yield the title compound as a pale yellow oil. LCMS, analytical method 2, TR=6.22 mins, 70%, Ml+H=368.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17282-03-0, 3-Bromo-2-chloro-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHARLES, Mark David; BROOKFIELD, Joanna Lola; EKWURU, Chukuemeka Tennyson; STOCKLEY, Martin Lee; WO2015/25172; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 17282-03-0 ,Some common heterocyclic compound, 17282-03-0, molecular formula is C6H5BrClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Bromo-2-ethoxy-5-methylpyridine To a solution of 3-bromo-2-chloro-5-methylpyridine (4.00 g, 19.37 mmol) in ethanol (100 mL) was added sodium ethoxide (6.59 g, 96.9 mmol) in three portions. The mixture was stirred under nitrogen at 100 C. for 2 days. The reaction was cooled to room temperature, diluted with water and extracted with DCM. The combined organic layers were dried (Na2SO4), and the solvent was removed under reduced pressure. Purification (FCC, SiO2, 20%, EtOAc/hexanes) afforded the title compound (3.00 g, 72%). 1H NMR (400 MHz, DMSO-d6) delta 7.94 (dd, J=0.8, 2.3 Hz, 1H), 7.89-7.82 (m, 1H), 4.31 (q, J=7.0 Hz, 2H), 2.18 (t, J=0.8 Hz, 3H), 1.30 (t, J=7.0 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17282-03-0, its application will become more common.

Reference:
Patent; Bollu, Venkataiah; Breitenbucher, James; Kaplan, Alan; Lemus, Robert; Lindstrom, Andrew; Vickers, Troy; Wilson, Mark E.; Zapf, James; US2014/275531; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 17282-03-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17282-03-0, name is 3-Bromo-2-chloro-5-methylpyridine. A new synthetic method of this compound is introduced below.

Example 143A 3-bromo-5-(bromomethyl)-2-chloropyridine 3-Bromo-2-chloro-5-methylpyridine (4 g, 19.37 mmol), N-bromosuccinimide (3.79 g, 21.3 mmol) and benzoic peroxyanhydride (0.239 g, 0.969 mmol) were combined in carbon tetrachloride (40 mL), heated under reflux for 24 hours, cooled, and filtered to remove succinimide. The filtrate was concentrated. The resulting residue was purified by chromatography (silica gel, 0-30% ethyl acetate in heptanes) to afford the title compound (1.9 g, 34%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17282-03-0, its application will become more common.

Reference:
Patent; Wang, Le; Pratt, John; Hasvold, Lisa A.; Liu, Dachun; Dai, Yujia; Fidanze, Steven D.; Holms, James H.; Mantei, Robert A.; McDaniel, Keith F.; Sheppard, George S.; McClellan, William J.; US2014/275026; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem