Category: 17322-91-7

Reference of 17322-91-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17322-91-7, name is 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one. A new synthetic method of this compound is introduced below.

Dissolve 5-hydroxy-1H-pyrrole[3,2]pyridine (10 mmol) in 40 ml of dichloromethane and add 10 ml to it.Triethylamine, controlled temperature below 10 C, adding 2-chloroacetyl chloride (12 mmol) in dichloromethane to the system, adding dropwiseAfter completion, return to room temperature, stir at room temperature for 10 hours, then wash the reaction system with 50 ml of 5% aqueous sodium carbonate solution, organic phase.After drying with anhydrous Na 2 SO 4 and evaporating the solvent, the obtained solid was separated by flash column chromatography.1.9 g pale yellow 2-chloro-1-(5-Hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid, yield 90%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17322-91-7, its application will become more common.

Reference:
Patent; Sang Qi; (10 pag.)CN108383838; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17322-91-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17322-91-7, name is 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one. A new synthetic method of this compound is introduced below.

Dissolve 5-hydroxy-1H-pyrrole[3,2]pyridine (10 mmol) in 40 ml of dichloromethane and add 10 ml to it.Triethylamine, controlled temperature below 10 C, adding 2-chloroacetyl chloride (12 mmol) in dichloromethane to the system, adding dropwiseAfter completion, return to room temperature, stir at room temperature for 10 hours, then wash the reaction system with 50 ml of 5% aqueous sodium carbonate solution, organic phase.After drying with anhydrous Na 2 SO 4 and evaporating the solvent, the obtained solid was separated by flash column chromatography.1.9 g pale yellow 2-chloro-1-(5-Hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid, yield 90%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17322-91-7, its application will become more common.

Reference:
Patent; Sang Qi; (10 pag.)CN108383838; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17322-91-7, name is 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, molecular formula is C7H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one

5-hydroxy -1H- pyrrolo [3,2] pyridine (10 mmol)Soluble in 40 ml of dichloromethane solution,Add 10 ml of triethylamine to it,Control temperature below 10 C,Add to the systema solution of 2-chloroacetyl chloride (12 mmol) in dichloromethane,After the addition is completed, return to room temperature.Stir at room temperature for 10 hours,The reaction system was then washed with 50 ml of a 5% aqueous solution of sodium carbonate.The organic phase is dried over anhydrous Na2SO4.After evaporating the solvent,The obtained solid is separated by flash column chromatography,Get 1.9 g light yellow2-Chloro-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid,The yield was 90%.

With the rapid development of chemical substances, we look forward to future research findings about 17322-91-7.

Reference:
Patent; Sang Qi; (10 pag.)CN108218865; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 17322-91-7, 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, blongs to pyridine-derivatives compound. Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one

Dissolve 5-hydroxy-1H-pyrrole [3,2] pyridine (10 mmol) in 40 ml of dichloromethane solution.10 ml of triethylamine was added thereto, and the temperature was controlled below 10 C.A solution of 2-chloroacetyl chloride (12 mmol) in dichloromethane was added dropwise to the system.After the addition was completed, the temperature was returned to room temperature, and the mixture was stirred at room temperature for 10 hours.The reaction system was then washed with 50 ml of a 5% aqueous solution of sodium carbonate and the organic phase was dried over anhydrous Na2SO4.After evaporating the solvent, the obtained solid was separated by flash column chromatography.1.9 g of pale yellow 2-chloro-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid were obtained in a yield of 90%.

The synthetic route of 17322-91-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sang Qi; (10 pag.)CN108456207; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem