Category: 1737-93-5

Electric Literature of 1737-93-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1737-93-5, name is 3,5-Dichloro-2,4,6-trifluoropyridine, molecular formula is C5Cl2F3N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of commercially available 3,5-dichloro-2,4,6-(trifluoro)pyridine 1 (1 mmole), aryl boronic acids 2a-f (1.0 mmol), Pd(OAc)2 (2 mol %), x-phos (5 mol %) K3PO4 (1.5 mmole) were added into a solution of H2O/DMF (1:1) (2 mL) in pressure tubes. The reaction mixture was stirred at 60C temperature for 8-12 hrs. After completion of reaction (TLC controlled), the organic and aqueous layers were separated and the latter was extracted with CH2Cl2 (3×25 mL). The combined organic layers were dried (Na2SO4), filtered, and the filtrate was concentrated in vacuo. The product was purified by column chromatography (silica gel, EtOAc/heptane). All products were characterized by NMR, GC-MS, HRMS, and IR spectroscopic techniques.

According to the analysis of related databases, 1737-93-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sharif, Muhammad; Shoaib, Khurram; Ahmed, Shahzad; Iqbal, Jamshed; Abilov, Zharylkasyn A.; Spannenberg, Anke; Langer, Peter; Tetrahedron Letters; vol. 57; 29; (2016); p. 3060 – 3062;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1737-93-5, name is 3,5-Dichloro-2,4,6-trifluoropyridine, molecular formula is C5Cl2F3N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 3,5-Dichloro-2,4,6-trifluoropyridine

S2.The above solution containing dichlorotrifluoropyridine was cooled to 10 C,And slowly dropping 30wt% aqueous ammonia at 10 C, the reaction was detected by TLC, to be dichloro-trifluoro pyridine reaction was complete,The reaction was stopped and a white solid was isolated as the desired drug intermediate (95.3% yield).

With the rapid development of chemical substances, we look forward to future research findings about 1737-93-5.

Reference:
Patent; Chongqing Huage Biochemical Co., Ltd.; He Xiaoqiang; Chen Zhizhong; Zhang Chunhua; Gu Fuhai; Wu Chengli; Yang Xinyao; (8 pag.)CN107311924; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1737-93-5, name is 3,5-Dichloro-2,4,6-trifluoropyridine. A new synthetic method of this compound is introduced below., COA of Formula: C5Cl2F3N

General procedure: A mixture of commercially available 3,5-dichloro-2,4,6-(trifluoro)pyridine 1 (1 mmole), aryl boronic acids 2a-i (2.2 mmol), Pd(OAc)2 (2 mol %), x-phos (5 mol %), and K3PO4 (1.5 mmole) was added into a solution of H2O/DMF (1:1) (2 mL) in pressure tubes. The reaction mixture was stirred at 60-80C for 12 hrs. After completion of reaction (TLC controlled), the organic and aqueous layers were separated and the latter was extracted with CH2Cl2 (3×25 mL). The combined organic layers were dried (Na2SO4), filtered, and the filtrate was concentrated in vacuo. The product was purified by column chromatography (silica gel, EtOAc/heptane). All products were characterized by NMR, GC-MS, HRMS, and IR spectroscopic techniques.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1737-93-5, 3,5-Dichloro-2,4,6-trifluoropyridine.

Reference:
Article; Sharif, Muhammad; Shoaib, Khurram; Ahmed, Shahzad; Iqbal, Jamshed; Abilov, Zharylkasyn A.; Spannenberg, Anke; Langer, Peter; Tetrahedron Letters; vol. 57; 29; (2016); p. 3060 – 3062;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1737-93-5, 3,5-Dichloro-2,4,6-trifluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1737-93-5, blongs to pyridine-derivatives compound. Application In Synthesis of 3,5-Dichloro-2,4,6-trifluoropyridine

Allgemeine Darstellung von [PENTAFLUORPYRIDIN (PFPY)] aus 3, [5-DICHLOR-2,] 4,6- [FLUORPYRIDIN] [(DCTFPY)] mittels [CHLOR-FLUOR-AUSTAUSCHREAKTION]. In 135 g [GESCHMOIZENEN SULFOLAN] (1,12 mol) werden nacheinander 11 [MMOL] des jeweiligen Katalysators, 38,3 g Kaliumfluorid (0,66 mol) und 50 g Chlorbenzol vorgelegt. Durch Destillation bei verminderten Druck wird die Mischung azeotrop getrocknet. Man [KueHLT AUF 40C] ab, ueberfuehrt in einen Autoklaven und gibt zu der warmen Reaktionsmischung 44,4 g 3, [5-DICHLOR-2,] 4, 6-fluorpyridin (0,22 mol). Man erhitzt auf [215C,] nach 22 Stunden wird auf Raumtemperatur abgekuehlt und der Gehalt an [PENTAFLUORPYRIDIN (PFPY)] gaschromatographisch bestimmt.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1737-93-5, its application will become more common.

Reference:
Patent; CLARIANT GMBH; WO2003/101926; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1737-93-5, name is 3,5-Dichloro-2,4,6-trifluoropyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5Cl2F3N

3,5-Dichloro-2,4,6-trifluoropyridine (2.01 g, 9.95 mmol) was ssolved in tetrahydrofuran (40 mL) and cooled to -78 C. ethylmagnesium chloride (6.2 mL, 12.40 mmol) was added slowly to the cooled solution and stirred for 30 minutes. Gradually allowed to warm to 0 C and monitored by LCMS until disappearance of starting material. Worked up with EtOAc (3x) and aq. saturated NaHCO3. The combined organics were washed with brine, dried over magnesium sulfate, filtered and gently concentrated to afford a volatile yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1737-93-5, 3,5-Dichloro-2,4,6-trifluoropyridine.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Nicholas David; BENOWITZ, Andrew B.; RUEDA BENEDE, Maria Lourdes; EVANS, Karen Anderson; FOSBENNER, David T.; KING, Bryan Wayne; LI, Mei; MILLER, William Henry; REIF, Alexander Joseph; ROMERIL, Stuart Paul; SCHMIDT, Stanley J.; WIGGALL, Kenneth; (1283 pag.)WO2017/216726; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem