Category: 174610-12-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 174610-12-9, name is 1H-Pyrrolo[2,3-c]pyridin-5-amine, the common compound, a new synthetic route is introduced below. Product Details of 174610-12-9

General procedure: To a solution of the corresponding amine (4 or 5, 1.2 equiv), dihalo-substituted benzoic acid (2c, 2d, 2e or 2f, 1.0 equiv), and 1-hydroxybenzotriazole hydrate (HOBt, 1.2 equiv) in DMF (8.0-10.0mL/mmol; extra dry over molecular sieves, 99.8%, Acros) were added EDC-HCl (1.2 eqiv) and DIPEA (2.5 equiv). The mixture was stirred at room temperature until completed conversion (TLC control: CH2Cl2/MeOH 9/1 v/v). Then, the solvent was removed in vacuo and the residue washed with water (20mL/mmol) and dried at 70C. The crude product was purified by column chromatography on silica gel (eluent: CH2Cl2/MeOH 9/1 v/v) following by reversed phase HPLC (for purification methods, see Supporting Information, TableS2) and/or recrystallization as described below.

The synthetic route of 174610-12-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tzvetkov, Nikolay T.; Stammler, Hans-Georg; Hristova, Silvia; Atanasov, Atanas G.; Antonov, Liudmil; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 793 – 809;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 174610-12-9 ,Some common heterocyclic compound, 174610-12-9, molecular formula is C7H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 5 (200 mg, 0.450 mmol) , 1H-pyrrolo [2, 3-c] pyridin-5-amine (120 mg, 0.90 mmol) , palladium (II) acetate (50 mg, 0.225 mmol) , xantphos (196 mg, 0.340 mmol) and potassium carbonate (124 mg, 0.90 mmol) in 1, 4-dioxane (10 mL) under heating at 100 through microwave irradiation for 1 hour under N2 atmosphere. LC-MS: m/z 539.2 (M+H) +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,174610-12-9, its application will become more common.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem