Category: 175422-04-5

Reference of 175422-04-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175422-04-5, name is 2,6-Dibromo-4-nitropyridine, molecular formula is C5H2Br2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

P. 2, 6-Dibromo-pyridin-4-ylamine A solution of 15.3 G (54.3 MMOL) 2,6-dibromo-4-nitro-pyridine and 18.5 ml (271.5 MMOL) 25% aq. ammonia in 40 mi tetrahydrofurane was transferred to an autoclave and heated at 95 C for 2.5 h. After cooling to room temperature, the reaction was poured into water (200 mi) and extracted with dichloromethane (3 x 200 ML). The organic layers were dried over magnesium sulphate and concentrated in vacuo. The residue was crystallized from ethyl acetate/petroleum ether to afford 9.6 G (70%) of the title compound as a yellow solid. m. p. 184-186 C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 175422-04-5, 2,6-Dibromo-4-nitropyridine.

Reference:
Patent; ALTANA PHARMA AG; WO2005/26164; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 175422-04-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.175422-04-5, name is 2,6-Dibromo-4-nitropyridine, molecular formula is C5H2Br2N2O2, molecular weight is 281.8896, as common compound, the synthetic route is as follows.

To a solution of 99A (0.473 g, 2.66 mmol) in l,4-Dioxane (20 mL) was added DIPEA (1.239 mL, 7.09 mmol) followed by 2,6-dibromo-4-nitropyridine (0.5 g, 1.774 mmol) sealed the tube and heated to 100 C for overnight. The reaction mass was cooled to RT and concentrated under reduced pressure. Purification by flash chromatography gave 101A (brown solid, 0.32 g, 0.842 mmol, 47.5 % yield). LC-MS Anal.Calc?d for CioHnBrFsNsCh 340.99, found [M+H] 342.2 Tr = 3.652 min (Method U).

Statistics shows that 175422-04-5 is playing an increasingly important role. we look forward to future research findings about 2,6-Dibromo-4-nitropyridine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; MARKWALDER, Jay A.; SHAN, Weifang; WILLIAMS, David K.; NARA, Susheel Jethanand; ROY, Saumya; THANGAVEL, Soodamani; CHERUKU, Srinivas; SISTLA, Ramesh Kumar; (230 pag.)WO2020/23355; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 175422-04-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 175422-04-5, name is 2,6-Dibromo-4-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Methanol (1.48 g, 46.1 mmol) is slowly added to a cooled suspension (00C) of NaH (2.12 g, 53.2 mmol, 60% dispersion in mineral oil, washed with hexane prior to use) in THF (20 ml_). Upon completion of the addition the mixture is stirred at 00C for 150 min before 2,6-dibromo-4-nitropyridine (10.0 g, 35.4 mmol) is added. The temperature rises to 14C. The mixture is stirred at rt for 3 h before the reaction is quenched with sat. aq. NH4CI solution. The mixture is diluted with water and extracted twice with EA (250 ml_). The combined org. extracts are dried over MgSO4, filtered and concentrated. The crude product is purified by CC on silica gel eluting with DCM to give 2,6-dibromo-4-methoxy-pyridine (6.43 g) as an off-white solid; LC-MS: tR = 0.90 min, [M+1]+ = 267.75.

According to the analysis of related databases, 175422-04-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/24905; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 175422-04-5, name is 2,6-Dibromo-4-nitropyridine. A new synthetic method of this compound is introduced below., COA of Formula: C5H2Br2N2O2

Methanesulfinic acid sodium salt (1.66 g, 16.3 mmol) is added to a solution of 2,6- dibromo-4-nitropyridine (0.917 g, 3.253 mmol) and DMF (15 ml_). After 1 h the DMF is removed in vacuo and the residue is taken up in CH2CI2 (150 ml.) and brine (150 ml_). The layers are mixed and then separated. The aqueous layer is extracted further with CH2CI2 (2 x 150 ml_). The combined organic layers are then dried (Na2SO4), filtered and concentrated. The residue is then separated via flash chromatography (SiO2, 5-30% EtOAc/heptane gradient) to give the title compound 2,6-dibromo-4-methanesulfonylpyridine as a white powder. MS (ESI) m/z 316.2 (M+1 ). 1H NMR (400 MHz, CDCI3) delta ppm 7.94 (s, 2 H), 3.12 (s, 3 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 175422-04-5, 2,6-Dibromo-4-nitropyridine.

Reference:
Patent; NOVARTIS AG; WO2009/150230; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 175422-04-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 175422-04-5, name is 2,6-Dibromo-4-nitropyridine. A new synthetic method of this compound is introduced below.

The solution of 2,6-dibromo-4-nitropyridine (0.4 g, 1.419 mmol) and 1, 2,3,4- tetrahydroisoquinoline (0.378 g, 2.84 mmol) in dioxane (2 mL) was stirred at 100 C for 14 h. The reaction mixture was concentrated under reduced pressure and the residue so obtained was purified through silica gel column chromatography by using 10-30% ethyl acetate and pet ether as an eluant to afford 91 A (brown solid, 0.75 g, 1.369 mmol, 48.3 % yield). LC-MS Anal.Calc?d for Ci4Hi2BrN302 333.0, found [M+2] 335.0 Tr = 3.76 min (Method N).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,175422-04-5, 2,6-Dibromo-4-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; MARKWALDER, Jay A.; SHAN, Weifang; WILLIAMS, David K.; NARA, Susheel Jethanand; ROY, Saumya; THANGAVEL, Soodamani; CHERUKU, Srinivas; SISTLA, Ramesh Kumar; (230 pag.)WO2020/23355; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 175422-04-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 175422-04-5 as follows.

A solution of 2,6-dibromo-4-nitropyridine (5.0 g, 17.74 mmol) in dioxane (100 mL) was treated with DIPEA (6.20 mL, 35.5 mmol), N-benzylethanamine, HC1 (3.65 g, 21.28 mmol) and heated to 100 C in a sealed tube for 18 h. LC-MS indicated completion. The dioxane was concentrated in vacuum, and the residue partitioned between IN HC1 (150 mL) and ethyl acetate (300 mL). The organic layer was separated, dried over Na2S04 and concentrated in vacuo. Purification via flash chromatography gave 1 A (yellow liquid, 5.0 g, 14.87 mmol, 84 % yield). ]H NMR (300MHz, CHLOROFORM-d) d 8.19 (s, 1H), 7.23-7.37 (m, 5H), 7.06 (d, J= 1.5 Hz, 1H), 4.77 (s, 2H), 3.60 (q, J= 7.2 Hz, 2H), 1.20 (t, J= 12 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175422-04-5, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; MARKWALDER, Jay A.; SHAN, Weifang; WILLIAMS, David K.; NARA, Susheel Jethanand; ROY, Saumya; THANGAVEL, Soodamani; CHERUKU, Srinivas; SISTLA, Ramesh Kumar; (230 pag.)WO2020/23355; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem