Category: 17570-98-8

Reference of 17570-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17570-98-8, name is 2-(Bromoacetyl)pyridine hydrobromide, molecular formula is C7H7Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

B) Synthesis of 2- (pyridin-2-yl)-2-bromomethyl-4-hydrox methyl-1, 3-dioxolane cisltrans 316 ml of glycerol were dissolved in 2 1 of toluene and 13.6 g of p- toluenesulfonic acid and 195 g of 2-bromoacetyl-pyridine hydrobromide were added to this solution. The reaction mixture was refluxed for 24 hours, with removal of the water present in the azeotrope. Once the mixture had cooled to ambient temperature, 2 1 of 5% NaHCO3 were added, the two-phase mixture was stirred for 5 minutes and the phases were then separated. The aqueous phase was extracted six times with 600 ml of toluene, the organic phases were combined, dehydrated with Na2S04, and evaporated to dryness under reduced pressure, giving rise to 80 g of (cis/trans)-2-(pyridin-2-yl)-2-bromomethyl-4- hydroxymethyl-1,3-dioxolane (yield 42%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide.

Reference:
Patent; ITALFARMACO S.P.A.; WO2005/40156; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17570-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17570-98-8, name is 2-(Bromoacetyl)pyridine hydrobromide, molecular formula is C7H7Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

B) Synthesis of 2- (pyridin-2-yl)-2-bromomethyl-4-hydrox methyl-1, 3-dioxolane cisltrans 316 ml of glycerol were dissolved in 2 1 of toluene and 13.6 g of p- toluenesulfonic acid and 195 g of 2-bromoacetyl-pyridine hydrobromide were added to this solution. The reaction mixture was refluxed for 24 hours, with removal of the water present in the azeotrope. Once the mixture had cooled to ambient temperature, 2 1 of 5% NaHCO3 were added, the two-phase mixture was stirred for 5 minutes and the phases were then separated. The aqueous phase was extracted six times with 600 ml of toluene, the organic phases were combined, dehydrated with Na2S04, and evaporated to dryness under reduced pressure, giving rise to 80 g of (cis/trans)-2-(pyridin-2-yl)-2-bromomethyl-4- hydroxymethyl-1,3-dioxolane (yield 42%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide.

Reference:
Patent; ITALFARMACO S.P.A.; WO2005/40156; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17570-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17570-98-8, name is 2-(Bromoacetyl)pyridine hydrobromide, molecular formula is C7H7Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

B) Synthesis of 2- (pyridin-2-yl)-2-bromomethyl-4-hydrox methyl-1, 3-dioxolane cisltrans 316 ml of glycerol were dissolved in 2 1 of toluene and 13.6 g of p- toluenesulfonic acid and 195 g of 2-bromoacetyl-pyridine hydrobromide were added to this solution. The reaction mixture was refluxed for 24 hours, with removal of the water present in the azeotrope. Once the mixture had cooled to ambient temperature, 2 1 of 5% NaHCO3 were added, the two-phase mixture was stirred for 5 minutes and the phases were then separated. The aqueous phase was extracted six times with 600 ml of toluene, the organic phases were combined, dehydrated with Na2S04, and evaporated to dryness under reduced pressure, giving rise to 80 g of (cis/trans)-2-(pyridin-2-yl)-2-bromomethyl-4- hydroxymethyl-1,3-dioxolane (yield 42%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide.

Reference:
Patent; ITALFARMACO S.P.A.; WO2005/40156; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 17570-98-8, blongs to pyridine-derivatives compound. SDS of cas: 17570-98-8

2-Bromo-1-(pyridin-2-yl)ethanone hydrobromide 8a(20.0 g, 71.1 mmol) and K2CO3 (14.8 g, 107 mmol) were suspended in acetone (100 mL), andthe suspension was stirred at room temperature for 1.5 hr. To a solution of ethyl cyanoacetate (60.4 g, 534 mmol) in acetone (100 mL) was addedK2CO3 powder (29.6 g, 214 mmol), and the mixture was stirred at 45C for 1 hr. To this mixture was added dropwise the suspension obtained earlier by small portions at 45C, and the resulting mixture was stirred at 45C for 3 h, filtered after cooled to room temperature, and then concentrated under reduced pressure. The residue was taken up withEtOAc, washed with H2O and brine, dried over anhydrous MgSO4, and concentrated under reduced pressure. To the obtained oil was added 4 mol/L HCl/EtOAc (250 mL) and the mixture was stirred at 60 C for 3 h, and concentrated under reduced pressure. A solution ofNaHCO3 was added to the residue and the mixture was extracted with EtOAc, washed with brine, dried over anhydrous MgSO4,and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/EtOAc = 4/1), then added dropwise 4 mol/L HCl/EtOAc (20 mL) after dissolved in EtOAc (20 mL), concentrated under reduced pressure, and crystalized from EtOAc to yieldcompound 10a (3.08 g, 15%) as a colorless solid: 1H-NMR (DMSO-d6)d 1.30 (3H, t, J=7.0 Hz), 4.25 (2H, q, J=7.0 Hz), 7.48-7.54 (2H, m), 8.13-8.19 (2H, m), 8.61-8.63 (1H, m), 13.47 (1H, br), 1H not detected.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide, and friends who are interested can also refer to it.

Reference:
Article; Nishida, Haruyuki; Arikawa, Yasuyoshi; Hirase, Keizo; Imaeda, Toshihiro; Inatomi, Nobuhiro; Hori, Yasunobu; Matsukawa, Jun; Fujioka, Yasushi; Hamada, Teruki; Iida, Motoo; Nishitani, Mitsuyoshi; Imanishi, Akio; Fukui, Hideo; Itoh, Fumio; Kajino, Masahiro; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3298 – 3314;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 17570-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17570-98-8, name is 2-(Bromoacetyl)pyridine hydrobromide, molecular formula is C7H7Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

9(B) (S)-(3,4-Difluoro-phenyl)(3-(4-(pyridin-2-yl)-oxazol-2-yl)-piperidin-l- yl)-methanone; A solution of (S)-l-(3,4-difluoro-benzoyl)-piperidine-3-carboxylic acid amide (0.214 g, 0.8 mmol) and 2-(bromoacetyl)-pyridine hydrobromide (90 mg, 0.32 mmol) in dry N-methyl-2-pyrrolidinone (3 mL) was heated at 110C for 7 h. The reaction mixture was cooled to room temperature, ethyl acetate was added and the organic layer was washed sequentially with water (twice) and with brine (twice). The organics were dried over sodium sulphate and evaporated under reduced pressure to afford a crude oil that was purified by flash chromatography (silica gel, eluent gradient: from DCM/MeOH/NH4OH 99:1 :0.1 to DCM/MeOH/NH4OH 98:2:0.2). The solid that was recovered from this purification was purified again by flash chromatography (silica gel, eluent: DCM/MeOH/NH4OH 99:1 :0.1) to afford 8.5 mg of (S)-(3,4-difluoro- phenyl)(3-(4-(pyridin-2-yl)-oxazol-2-yl)-piperidin-l-yl)-methanone, obtained as a yellow gummy solid. Yield: 7%; LCMS (RT): 4.44 min (Method I); MS (ES+) gave m/z: 370.4 (MH+). EPO 1H-NMR (CDCl3, 328K), delta (ppm): 8.59 (ddd, IH) 8.17 (s, IH) 7.85 (ddd, IH) 7.73 (ddd, IH) 7.29-7.34 (m, IH) 7.16-7.25 (m, 3H) 4.29-4.39 (m, IH) 3.93-4.03 (m, IH) 3.53 (dd, IH) 3.27 (ddd, IH) 3.07-3.18 (m, IH) 1.83-2.06 (m, 2H) 1.68 (br. s., IH).

According to the analysis of related databases, 17570-98-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ADDEX PHARMA S.A.; WO2008/56259; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 17570-98-8 ,Some common heterocyclic compound, 17570-98-8, molecular formula is C7H7Br2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Compounds 17-29and 43-61 were prepared following this general protocol unless otherwise noted. To substituted2-bromoethanone in ethanol was added substituted thiourea (1.02 eq). The mixture wasstirred at 70C. The reaction was monitored via LC/MS. After 2 h, the reaction mixture wascooled to room temperature and precipitate was formed. The precipitate was collected by vacuumfiltration and washed with acetone. The solid was dissolved in 2 MNaOH (25 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were dried over Na2SO4 andconcentrated in vacuo desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17570-98-8, its application will become more common.

Reference:
Article; Kesicki, Edward A.; Bailey, Mai A.; Ovechkina, Yulia; Early, Julie V.; Alling, Torey; Bowman, Julie; Zuniga, Edison S.; Dalai, Suryakanta; Kumar, Naresh; Masquelin, Thierry; Hipskind, Philip A.; Odingo, Joshua O.; Parish, Tanya; PLoS ONE; vol. 11; 5; (2016);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem