Category: 1762-41-0

Nagata, Kojiro; Otsuji, Naoko; Akagi, Soichiro; Fujii, Sho; Kitamura, Noboru; Yoshimura, Takashi published the artcile< Synthesis, Structures, and Photoluminescent Properties of Tricyanidonitridorhenium(V) Complexes with Bipyridine-Type Ligands>, Application of C10H6Cl2N2, the main research area is crystal structure rhenium nitrido cyano substituted bipyridine; rhenium tricyanidonitrido bipyridine preparation electrochem redox luminescence charge transfer.

Tricyanidonitridorhenium(V) complexes with 2,2′-bipyridine (bpy) derivatives in which the 4 and 4′ positions were substituted by X, [ReN(CN)3(X2bpy)]- (X = NMe2, NH2, OMe, Me, Cl, and Br), were newly synthesized and characterized. The structures of the new complexes were determined by single-crystal x-ray anal. UV-visible spectra of the complexes in DMSO showed that the peak maximum wavelengths of Re-to-π* bpy-type-ligand charge transfer were at 474-542 nm. Cyclic voltammograms in Bu4NPF6-DMSO showed 1-electron oxidation and reduction waves corresponding to the Re(VI/V) and X2bpy0/- processes, resp. The new complexes and [ReN(CN)3bpy]- showed photoluminescence in the crystalline phase at 295 and 80 K and in DMSO at 295 K. The origin of the emission in DMSO was attributed to the triplet nature of the Re-to-π* bpy-type-ligand charge-transfer transition. D. functional theory calculations showed that the highest occupied and lowest unoccupied MOs were primarily localized on the dxy orbital of the Re and π* orbitals of the bpy-type ligand, resp. Tricyanidonitridorhenium(V) complexes with 2,2′-bipyridine (bpy) derivatives were newly synthesized and characterized. The new complexes and [ReN(CN)3bpy]- showed photoluminescence. The origin of the emission was attributed to the triplet nature of the Re-to-π* bpy-derivative charge-transfer transition.

Inorganic Chemistry published new progress about Charge transfer transition. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morales-Colon, Maria T.; See, Yi Yang; Lee, So Jeong; Scott, Peter J. H.; Bland, Douglas C.; Sanford, Melanie S. published the artcile< Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination>, Recommanded Product: 4,4′-Dichloro-2,2′-bipyridine, the main research area is aryl chloride tetramethylammonium fluoride regioselective nucleophilic aromatic fluorination; aromatic fluoride preparation.

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations was the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alc. adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alc. substituent (R), tetramethylammonium fluoride tert-amyl alc. (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80°C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles was demonstrated.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Recommanded Product: 4,4′-Dichloro-2,2′-bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Webster, Alyssa A.; Huo, Jianqiang; Milliken, Jenna; Sullivan, Pat; Kubelka, Jan; Hoberg, John O. published the artcile< Hydrogen gas formation from the photolysis of rhenium hydrides - mechanistic and computational studies>, COA of Formula: C10H6Cl2N2, the main research area is dihydrogen elimination kinetics photolysis bipyridine rhenium hydride substituent effect; bipyridine rhenium hydride preparation kinetics photolysis dihydrogen elimination; optimized geometry bipyridine rhenium hydride photolysis dihydrogen elimination DFT.

The photolysis of 4,4′-disubstituted, 2,2′-bipyridine fac-Re(bpy)(CO)3H derivatives produces stoichiometric H2 gas. The rate of production varies greatly depending on the electronic nature of the disubstituted bipyridine (bpy) with halogenated substituents increasing the rate. Isotope labeling studies along with B3LYP geometry optimization DFT modeling studies indicate a mechanism involving a Re-H-Re bridging complex that leads to a dimeric Re-Re(η2-H2) state prior to dissociating H2 gas.

Dalton Transactions published new progress about Hydrides Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation) (bipyridine rhenium hydrides). 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, COA of Formula: C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kalkman, Eric D.; Mormino, Michael G.; Hartwig, John F. published the artcile< Unusual Electronic Effects of Ancillary Ligands on the Perfluoroalkylation of Aryl Iodides and Bromides Mediated by Copper(I) Pentafluoroethyl Complexes of Substituted Bipyridines>, Safety of 4,4′-Dichloro-2,2′-bipyridine, the main research area is Perfluoroalkylation aryl halides Copper pentafluoroethyl complex Bipyridines LFER; kinetics Perfluoroalkylation aryl halides Copper pentafluoroethyl complex Bipyridines.

Several perfluoroalkylcopper compounds have been reported previously that serve as reagents or catalysts for the perfluoroalkylation of aryl halides. However, the relationships between the reactivity of such complexes and the electronic properties of the ancillary ligands are unknown, and such relationships are not well-known in general for copper complexes that mediate or catalyze cross coupling. We report the synthesis and characterization of a series of pentafluoroethylcopper(I) complexes ligated by bipyridine ligands possessing varied electronic properties. In contrast to the limited existing data on the reactivity of L2Cu(I)-X complexes bearing amine and pyridine-type ligands in Ullmann-type aminations with aryl halides, the reactions of aryl halides with pentafluoroethylcopper(I) complexes bearing systematically varied bipyridine ligands were faster for complexes bearing less electron-donating bipyridines than for complexes bearing more electron-donating bipyridines. Anal. of the rates of reaction and the relative populations of the neutral complexes and ionic complexes formed by these reagents in solution suggests that this effect of electronics on the reaction rate results from an unusual trend of faster oxidative addition of aryl halides to complexes containing less electron-donating ligands than to those containing more electron-donating ligands.

Journal of the American Chemical Society published new progress about Activation enthalpy. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Safety of 4,4′-Dichloro-2,2′-bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xuan; McNally, Andrew published the artcile< Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts>, Application of C10H6Cl2N2, the main research area is alkylheterocycle regioselective preparation; heterocyclic phosphonium salt preparation organozinc alkylation cobalt catalyst; alkyl Negishi; alkylation; cobalt-catalysis; cross-coupling; late-stage; phosphonium salts; pyridines.

Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes. We present a cobalt-catalyzed coupling reaction between pyridine phosphonium salts and alkylzinc reagents that can be applied to complex drug-like fragments and for late-stage functionalization of pharmaceuticals. The reaction generally proceeds at room temperature, and 4-position pyridine C-H bonds are the precursors in this strategy. Given the challenges in selectively installing (pseudo)halides in complex pyridines, this two-step process enables sets of mols. to be alkylated that would be challenging using traditional cross-coupling methods.

ACS Catalysis published new progress about Alkylation. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tatikonda, Rajendhraprasad; Cametti, Massimo; Kalenius, Elina; Famulari, Antonino; Rissanen, Kari; Haukka, Matti published the artcile< Mononuclear Ru(II) PolyPyridyl Water Oxidation Catalysts Decorated with Perfluoroalkyl C8H17-Tag Bearing Chains>, Application In Synthesis of 1762-41-0, the main research area is mononuclear ruthenium polypyridyl complex preparation crystal mol structure; water oxidation catalyst decorated perfluoroalkyl polypyridyl mononuclear ruthenium complex; perfluoroundecyl polypyridyl ruthenium complex preparation crystal mol structure.

A set of novel polypyridyl Ru(II) complexes 1-7, decorated with one, two or three C8F17 tags have been synthesized and characterized by NMR, UV/Vis spectroscopy and, in the case of series of complexes 1-3, 5 and 7 by x-ray diffraction on single crystals. Solid state structures of 3, 5 and 7 were also subjected to computational DFT study in order to gain insights into the effect of a different number of perfluorinated tags on their stability in the solid-state. The complexes are stable in solution under strongly oxidative conditions, do keep catalytic activity in their aquo forms (1′-7′) comparing well with parent complex 8′, and their amphiphilic nature could allow for their incorporation in fluorous media and interfaces.

European Journal of Inorganic Chemistry published new progress about Crystal structure. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application In Synthesis of 1762-41-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Longjia; Liu, Zibo; Tang, Shanyu; Li, Jiao; Ren, Xuanhe; Yang, Guanyu; Li, Heng; Yuan, Bingxin published the artcile< Amphiphilic ligands for Cu-catalyzed aerobic oxidation to synthesize 9-fluorenones in water>, Product Details of C10H6Cl2N2, the main research area is fluorenone preparation; fluorene aerobic oxidation copper catalyst.

A series of amphiphilic PEG-functionalized nitrogen ligands were developed for the highly efficient copper-catalyzed aerobic oxidation of 9-fluorenes, with mol. oxygen as the sole oxidant in neat water to afford 9-fluorenones I [R = H, 2-NH2, 2-I, etc.]. A broad range of functional groups were well tolerated and thus offered the opportunity for further functionalization.

Catalysis Communications published new progress about Fluorenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Product Details of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

De Bon, Francesco; Abreu, Carlos M. R.; Serra, Armenio C.; Gennaro, Armando; Coelho, Jorge F. J.; Isse, Abdirisak A. published the artcile< Catalytic Halogen Exchange in Supplementary Activator and Reducing Agent Atom Transfer Radical Polymerization for the Synthesis of Block Copolymers>, Related Products of 1762-41-0, the main research area is halogen exchange activator reducing agent ATRP block copolymer; ATRP; block copolymerization; catalytic halogen exchange; copper catalyst; supplemental activator.

Synthesis of block copolymers (BCPs) by catalytic halogen exchange (cHE) is reported, using supplemental activator and reducing agent Atom Transfer Radical Polymerization (SARA ATRP). The cHE mechanism is based on the use of a small amount of a copper catalyst in the presence of a suitable excess of halide ions, for the synthesis of block copolymers from macroinitiators with monomers of mismatching reactivity. cHE overcomes the problem of inefficient initiation in block copolymerizations in which the second monomer provides dormant species that are more reactive than the initiator. Model macroinitiators with low dispersity are prepared and extended to afford well-defined block copolymers of various compositions Combined cHE/SARA ATRP is therefore a simple and potent polymerization tool for the copolymerization of a wide range of monomers allowing the production of tailored block copolymers.

Macromolecular Rapid Communications published new progress about Atom transfer radical polymerization catalysts. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Related Products of 1762-41-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Karges, Johannes; Kalaj, Mark; Gembicky, Milan; Cohen, Seth M. published the artcile< ReI tricarbonyl complexes as coordinate covalent inhibitors for the SARS-CoV-2 main cysteine protease>, Product Details of C10H6Cl2N2, the main research area is rhenium tricarbonyl complex coordinate inhibitor main protease SARS CoV2; synthesis crystal structure rhenium tricarbonyl complex protease inhibitor 3CLpro; SARS-CoV-2; antiviral agents; bioinorganic chemistry; medicinal inorganic chemistry; protease inhibitor.

Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CLpro), which is also known as the main protease, is considered among the most important pharmacol. targets. The vast majority of investigated 3CLpro inhibitors are organic, non-covalent binders. Herein, the use of inorganic, coordinate covalent binders is proposed that can attenuate the activity of the protease. ReI tricarbonyl complexes were identified that demonstrate coordinate covalent enzymic inhibition of 3CLpro. Preliminary studies indicate the selective inhibition of 3CLpro over several human proteases. This study presents the first example of metal complexes as inhibitors for the 3CLpro cysteine protease.

Angewandte Chemie, International Edition published new progress about Anticoronaviral agents. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Product Details of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ielasi, Guido; Alcover, Gerard; Casellas, Josep; de Graaf, Coen; Orellana, Guillermo; Reguero, Mar published the artcile< Computer-aided design of short-lived phosphorescent Ru(II) polarity probes>, Name: 4,4′-Dichloro-2,2′-bipyridine, the main research area is ruthenium polypyridyl complex fluorescent polarity density functional theory.

Fluorescent polarity probes are usually based on intramol. charge transfer excited states of selected dyes, the behavior of which in different solvents is traditionally rationalized by the well-known Lippert-Mataga treatment of the “”general solvents effect””. Less often transition metal coordination complexes are used as luminescent probes, even though the spectroscopic properties of these dyes are usually dependent on the environment. This is the case of Ru(II) polypyridyls, which are good candidates to develop robust sensitive polarity probes because of their lowest-lying metal-to-ligand charge transfer triplet emissive state, provided their chelating ligands structure is judiciously tuned. The aim of this work has been to design a computational strategy to forecast the behavior of polarity-sensitive Ru(II) complexes without the need to prepare a large set of candidates. In particular, we have analyzed a number of complexes derived from [Ru(bpy)3]2+ by introducing different pairs of substituents in the 4,4′ positions of one of the three equivalent 2,2′-bipyridine (bpy) moieties. In this way, we have investigated if a direct relationship may be established between the electronic features of the substituent and the Stokes shift sensitivity to the solvent polarity. Our computational data satisfactorily agree with our exptl. results, but they demonstrate that only by explicitly performing the calculation of the Stokes shift in different media for each candidate, it is possible to select the best Ru(II) dyes to be used as polarity probes.

Dyes and Pigments published new progress about Photoluminescence. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Name: 4,4′-Dichloro-2,2′-bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem