Category: 176526-00-4

Electric Literature of 176526-00-4, Adding some certain compound to certain chemical reactions, such as: 176526-00-4, name is 2-(Pyridin-4-yl)benzaldehyde,molecular formula is C12H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 176526-00-4.

A solution of tetrabutylammonium fluoride (0.027 ml; 1.0 M in tetrahydrofuran) was added to a solution of 2-pyridin-4-yl-benzoAldehyde (500 mg, 2.73 mmol) and trifluoromethyltrimethylsilane (TMSCF3) (485 mul, 3.28 mmol) in 5 ml of THFin. The resulting mixture was warmed to room temperature and stirred at room temperature for 4 hours. The reaction mixture was then washed with 5 ml of 1N HClAnd stirred overnight at room temperature. The solvent was evaporated to dryness, 9 ml of a 1 M aqueous solution of sodium carbonate was added and the aqueous phase was extracted with chloroform (3 x10 ml), the combined chloroform layers were washed with water and dried over MgSO4. Evaporation of the organic solvent gave 300 mg of 2,2,2-trifluoro-l- (2-Pyridin-4-yl-phenyl) ethanol in a yield of 43%.

According to the analysis of related databases, 176526-00-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Laixiken Pharmaceutical Co., Ltd.; A Luojiyasami·dewasajiayalayi; Jin Haihong; Shi Zhicai; A Xiaoke·tunuli; Wang Ying; Zhang Chengmin; (63 pag.)CN104045626; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 176526-00-4, Adding some certain compound to certain chemical reactions, such as: 176526-00-4, name is 2-(Pyridin-4-yl)benzaldehyde,molecular formula is C12H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 176526-00-4.

A solution of tetrabutylammonium fluoride (0.027 ml; 1.0 M in tetrahydrofuran) was added to a solution of 2-pyridin-4-yl-benzoAldehyde (500 mg, 2.73 mmol) and trifluoromethyltrimethylsilane (TMSCF3) (485 mul, 3.28 mmol) in 5 ml of THFin. The resulting mixture was warmed to room temperature and stirred at room temperature for 4 hours. The reaction mixture was then washed with 5 ml of 1N HClAnd stirred overnight at room temperature. The solvent was evaporated to dryness, 9 ml of a 1 M aqueous solution of sodium carbonate was added and the aqueous phase was extracted with chloroform (3 x10 ml), the combined chloroform layers were washed with water and dried over MgSO4. Evaporation of the organic solvent gave 300 mg of 2,2,2-trifluoro-l- (2-Pyridin-4-yl-phenyl) ethanol in a yield of 43%.

According to the analysis of related databases, 176526-00-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Laixiken Pharmaceutical Co., Ltd.; A Luojiyasami·dewasajiayalayi; Jin Haihong; Shi Zhicai; A Xiaoke·tunuli; Wang Ying; Zhang Chengmin; (63 pag.)CN104045626; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 176526-00-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 176526-00-4, name is 2-(Pyridin-4-yl)benzaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

6.5. Synthesis of (S)-2-Amino-3-(4-{6-[2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)-ethoxy]-pyrimidin-4-yl}-phenyl)-propionic acid Tetrabutylammonium fluoride (0.027 ml; 1.0 M solution in tetrahydrofuran) was added to a solution of 2-pyridin-4-yl-benzaldehyde (500 mg, 2.73 mmol) and trifluoromethyltrimethylsilane (TMSCF3) (485 mul, 3.28 mmol) in 5 ml of THF at 0 C. The formed mixture was warmed up to room temperature and stirred at room temperature for 4 hours. The reaction mixture was then treated with 5 ml of 1N HCl and stirred at room temperature overnight. The solvent was evaporated to dryness, 9 ml of 1M sodium carbonate aqueous solution was added, the aqueous phase was extracted with chloroform (3*10 ml), and the combined organic layer was washed with water, dried over MgSO4. The organic solvent was evaporated to give 300 mg of 2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)ethanol, yield: 43%.

According to the analysis of related databases, 176526-00-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jin, Haihong; Shi, Zhi-Cai; Tunoori, Ashok; Wang, Ying; Zhang, Chengmin; Devasagayaraj, Arokiasamy; US2008/153852; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 176526-00-4 ,Some common heterocyclic compound, 176526-00-4, molecular formula is C12H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(b) 4-[2-((E)-2-Iodovinyl)phenyl]pyridine: In a similar manner to that of Example 1(d), starting with 1.98 g (10.8 mmol) of 2-pyrid-4-ylbenzaldehyde obtained in Example 50(a), 490 mg (15%) of the expected compound are obtained in the form of a green oil. 1 H NMR (CDCl3) delta 6.84 (d, 1H, J=14.8 Hz), 7.28 to 7.51 (m, 7H), 8.69 (d, 2H, J=5.5 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 176526-00-4, 2-(Pyridin-4-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Centre International de Recherches Dermatologiques; US6150413; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176526-00-4, name is 2-(Pyridin-4-yl)benzaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-(Pyridin-4-yl)benzaldehyde

General procedure: A mixture of 4-hydroxycoumarine 1 (162 mg, 1 mmol), thearomatic aldehydes 2a-l (1 mmol; 106, 185, 141, 175, 131, 122,136, 120, 151, 96, 107, and 112 mg, respectively), 6-amino-1,3-dimethyluracil 3 (155 mg, 1 mmol), and Fe3O4TiO2 NPs(0.02 g), in H2O (2 mL) were stirred at ambient temperaturefor 2-3 h (see Table 2). After completion of the reactionas indicated by thin layer chromatography (eluent/ethyl acetate-petrol = 3:1), the reaction mixture was dilutedwith DMF (1 mL) and the catalyst was recovered from thereaction mixture by simply using an external magnet. Forreuse, the catalyst was washed with EtOH and dried in airat ambient temperature for several hours. The remainingsolution was diluted with H2O (1 mL), to yield the pureproducts by recrystallization from this solution.

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Reference:
Article; Fakheri-Vayeghan, Sakineh; Abdolmohammadi, Shahrzad; Kia-Kojoori, Reza; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 73; 8; (2018); p. 545 – 551;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem