Category: 178421-21-1

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 178421-21-1, name is Ethyl 6-chloro-5-methylpicolinate, the common compound, a new synthetic route is introduced below. Recommanded Product: 178421-21-1

Stage 1: (6-chloro-5-methylpyridin-2-yl)methanol 0.40 g of sodium borohydride (10.5 mmol) is added in portions to a solution of 1.20 g of 6-chloro-5-methylpyridine-2-carboxylic acid ethyl ester (6.00 mmol) and 10 ml of ethanol maintained at room temperature. The mixture is stirred for 4 hours and then the mixture is poured into an aqueous solution of sodium chloride and the mixture is extracted with ethyl acetate. The organic phase is dried over sodium sulfate, filtered and concentrated under vacuum. The title product is isolated by chromatography on a silica column (eluent: chloroform). 0.69 g of a colorless oil is recovered. Yield: 73% 1 H NMR (CDCl3) delta: 2.37 (s, 3H); 4.70 (s, 2H); 2.94 (s; broad); 7.17 (d, 1H); 7.55 (d, 1H)

The synthetic route of 178421-21-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pierre Fabre Medicament; US6020345; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.178421-21-1, name is Ethyl 6-chloro-5-methylpicolinate, molecular formula is C9H10ClNO2, molecular weight is 199.63, as common compound, the synthetic route is as follows.name: Ethyl 6-chloro-5-methylpicolinate

l-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(4,4,5,5-tetramethyl-1,3 ,2- dioxaborolan-2-yl)-1,3 -dihydro-2,1,3-benzothiadiazole 2,2-dioxide (12-1) (100 mg, 0.25 mmol, 1 eq), ethyl 6-chloro-5-methylpyridine-2-carboxylate (26-4) (75 mg, 0.38 mmol, 1.5 eq), tripotassium phosphate (106 mg, 0.50 mmol, 2.0 eq), S-Phos (10 mg, 0.025 mmol, 0.1 eq), and palladium(II) acetate (2.8 mg, 0.012 mmol, 0.05 eq) were combined in THF (1 mL) and water (0.2 mL). The resulting mixture was heated at 75 C for 14 hours. The reaction mixture was allowed to cool to room temperature. The mixture was then diluted with EtOAc (10 mL), washed with water (1 mL) and brine (1 mL), dried over MgS04, filtered and concentrated. The crude residue was purified by flash chromatography (12 g Si02, 0-80% EtOAc in hexanes) to afford ethyl 6- { 1 -[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido- 1 ,3-dihydro-2, 1 ,3- benzothiadiazol-5-yl}-5-methylpyridine-2-carboxylate (26-5). HRMS m/z (M+H) 438.1291 found, 438.1294 required.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,178421-21-1, Ethyl 6-chloro-5-methylpicolinate, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LAYTON, Mark, E.; KELLY, Michael, J.; HARTINGH, Timothy, J.; WO2011/109277; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 178421-21-1, Adding some certain compound to certain chemical reactions, such as: 178421-21-1, name is Ethyl 6-chloro-5-methylpicolinate,molecular formula is C9H10ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 178421-21-1.

Step 1: 2-Carboxamido-5-methyl-6-chloropyridine (IX). Dissolve 26 g of 2-ethoxycarbonyl-5-methyl-6-chloro-pyridine (crude oil containing about 60% of ester) in 130 ml of methanol.Add 200 ml of 32% aqueous ammonia and stir overnight at room temperature.The product is recovered by filtration and gives, after washing with water and drying under vacuum, 13 g of white crystals. m.p.=146 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 178421-21-1, Ethyl 6-chloro-5-methylpicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Maurel, Jean-Louis; Bonnaud, Bernard; Ribet, Jean-Paul; Vacher, Bernard; US2004/116705; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 178421-21-1, Adding some certain compound to certain chemical reactions, such as: 178421-21-1, name is Ethyl 6-chloro-5-methylpicolinate,molecular formula is C9H10ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 178421-21-1.

Step 1: 2-Carboxamido-5-methyl-6-chloropyridine (IX). Dissolve 26 g of 2-ethoxycarbonyl-5-methyl-6-chloro-pyridine (crude oil containing about 60% of ester) in 130 ml of methanol.Add 200 ml of 32% aqueous ammonia and stir overnight at room temperature.The product is recovered by filtration and gives, after washing with water and drying under vacuum, 13 g of white crystals. m.p.=146 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 178421-21-1, Ethyl 6-chloro-5-methylpicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Maurel, Jean-Louis; Bonnaud, Bernard; Ribet, Jean-Paul; Vacher, Bernard; US2004/116705; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem