Category: 1796-84-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1796-84-5, name is 4-Ethoxy-3-nitropyridine, the common compound, a new synthetic route is introduced below. Formula: C7H8N2O3

Example 82; 3-(2-Butynyl-1-methyl-4-piperazin-1-yl-1,3-dihydroimidazo[4.5-c]pyridin-2-one; 82a) Methyl-(3-nitro-pyridin-4-yl)amine; [] 4-Ethoxy-3-nitropyridine (10.0 g) was dissolved in a 40% methanol solution of methyl amine (100 mL), and this was heated at 80C for 60 hours. The solution was cooled, ethyl acetate (500 mL) was added, and the organic layer was washed twice with 300 mL of water and once with 300 mL of saturated aqueous sodium chloride solution. This was then dried over anhydrous magnesium sulfate. The solution was filtered, and concentrated under reduced pressure to give the title compound (7.00 g).

The synthetic route of 1796-84-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; EP1568699; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1796-84-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1796-84-5 as follows.

4-Ethoxy-3-nitropyridine, hydrochloride (14.5 g, 70.8 mmol) in ethyl acetate was washed twice with 1 N NaHCO3. The organic layer was dried over MgS04, filtered and the solvent evaporated under reduced pressure to give 11.8 g of a light tan solid. The free-amine (11.8 g, 69.9 mmol) and cyclopropanemethylamine (5.00 g, 70.3 mmol) in EtOH were heated at 80 C in a sealed tube for 12 h. After allowing to warm to RT, the solvent was removed under reduced pressure to give a yellow oil. Flash chromatography (silica gel, hexanes then hexanes/Et2O (1: 1: 1) then Et2O/CH2CI2 (1: 1) then CH2CI2) gave 13.1 g of the desired material. MS (ES) m/z 194.2 [M+H] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1796-84-5, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/46678; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1796-84-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1796-84-5, name is 4-Ethoxy-3-nitropyridine, molecular formula is C7H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution consisting of 4-ethoxy-3-nitropyridine (15.0 g, 97.3 mmol) and EtNH2 (46.5 mL, 70% aq. solution, 584 mmol) in EtOH (30 mL) was stirred at 85 C in a pressure vessel for 2 h. Removal of all volatiles in vacuo afforded the title compound (16.2 g, 99 %). MS (ES+) m/z 168 (M+H) +.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1796-84-5, 4-Ethoxy-3-nitropyridine.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/46678; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1796-84-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1796-84-5 as follows.

4-Ethoxy-3-nitropyridine, hydrochloride (14.5 g, 70.8 mmol) in ethyl acetate was washed twice with 1 N NaHCO3. The organic layer was dried over MgS04, filtered and the solvent evaporated under reduced pressure to give 11.8 g of a light tan solid. The free-amine (11.8 g, 69.9 mmol) and cyclopropanemethylamine (5.00 g, 70.3 mmol) in EtOH were heated at 80 C in a sealed tube for 12 h. After allowing to warm to RT, the solvent was removed under reduced pressure to give a yellow oil. Flash chromatography (silica gel, hexanes then hexanes/Et2O (1: 1: 1) then Et2O/CH2CI2 (1: 1) then CH2CI2) gave 13.1 g of the desired material. MS (ES) m/z 194.2 [M+H] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1796-84-5, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/46678; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1796-84-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1796-84-5, name is 4-Ethoxy-3-nitropyridine, molecular formula is C7H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution consisting of 4-ethoxy-3-nitropyridine (15.0 g, 97.3 mmol) and EtNH2 (46.5 mL, 70% aq. solution, 584 mmol) in EtOH (30 mL) was stirred at 85 C in a pressure vessel for 2 h. Removal of all volatiles in vacuo afforded the title compound (16.2 g, 99 %). MS (ES+) m/z 168 (M+H) +.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1796-84-5, 4-Ethoxy-3-nitropyridine.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/46678; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1796-84-5, Adding some certain compound to certain chemical reactions, such as: 1796-84-5, name is 4-Ethoxy-3-nitropyridine,molecular formula is C7H8N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1796-84-5.

A solution consisting of 4-ethoxy-3-nitropyridine (15.0 g, 97.3 MMOL) and EtNH2 (46.5 mL, 70% aq. solution, 584 MMOL) in ETOH (30 mL) was stirred at 85 C in a pressure vessel for 2 h. Removal of all VOLATILES IN VACUO afforded the title compound (16.2 g, 99 %). MS (ES+) m/z 168 (M+H) +.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1796-84-5, 4-Ethoxy-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/11700; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1796-84-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1796-84-5, name is 4-Ethoxy-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 4: 1-N,N-Dimethylcarbamoyl-4-methoxycarbonyl-3-[5-(N-3-nitropyridin-4-yl)aminomethylthien-2-oyl]indole. To a solution of 1-N,N-dimethylcarbamoyl4-methoxycarbonyl-3-(5-aminomethylthien-2-oyl)indole (0.896 g, 2.33 mmol) in CH3 CN (5 mL) was added 4-ethoxy-3-nitropyridine (0.428 g, 2.55 mmol) and the reaction mixture was heated at reflux for 17 hours, then the solvent was removed in vacuo and the residue heated at 100 C. for 2 hours. The reaction mixture was then put under high vacuum to give 1-N,N-dimethylcarbamoyl-4-methoxycarbonyl-3-[5-(N-3-nitropyridin-4-yl)aminomethylthien-2-oyl]indole as a brown foam which was used without further purification.

According to the analysis of related databases, 1796-84-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Abbott Laboratories; US5486525; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1796-84-5, 4-Ethoxy-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1796-84-5, blongs to pyridine-derivatives compound. SDS of cas: 1796-84-5

Step 7: 3-[(4-(N-3-Nitropyrid-4-yl)aminomethyl)phenylsulfonyl]indole. A solution of 1-phenylsulfonyl-3-[(4-aminomethyl)phenylsulfonyl]indole (2.10 g, 4.79 mmol), prepared in step 6, and 4-ethoxy-3-nitropyridine (0.894 g, 5.31 mmol) in ethanol (20 mL) and triethylamine (1 mL) was heated at reflux for 70 hours. The reaction mixture was cooled to ambient temperature and diluted with ethyl acetate (250 mL). The organic phase was washed twice with H2 O and once with brine. The combined aqueous washings were extracted with ethyl acetate. The combined organic as layers were dried over Na2 SO4, filtered, and concentrated in vacuo. Chromatography on silica gel (ethyl acetate, then 0.2% ethanol/ethyl acetate) followed by recrystallization from ethyl acetate/ether gave 3-[(4-(N-3-nitropyrid-4-yl)aminomethyl)phenylsulfonyl]indole (350 mg, 23% yield). mp 97-102 C.

The synthetic route of 1796-84-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Abbott Laboratories; US5486525; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1796-84-5, 4-Ethoxy-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1796-84-5, blongs to pyridine-derivatives compound. Computed Properties of C7H8N2O3

Step 4: 1-N,N-Dimethylcarbamoyl-4-bromo-3-(4-(N-3-nitropyridin-4-yl)aminomethylbenzoyl)indole. A mixture of the 1-N,N-dimethylcarbamoyl-4-bromo-3-(4-aminomethylbenzoyl)indole prepared in step 3 (13.65 g) and 4-ethoxy-3-nitropyridine (5.10 g, 30.3 mmol) in CH3 CN (50 mL) was heated at reflux for 50 hours during which time 46 mL of solvent distilled out. To the thick residue was added toluene (50 mL) and the mixture was heated at a rate such that 21 mL of solvent distilled off over 2 hours. The reaction mixture was cooled to ambient temperature and diluted with ethyl acetate (30 mL). The solution was placed directly on a silica gel column and eluted with 50%, then 80% ethyl acetate/toluene to give 1-N,N-dimethylcarbamoyl-4-bromo-3-(4-(N-3-nitropyridin-4-yl)aminomethylbenzoyl)indole (6.76 g), mp 173.5-174.5 C. after crystallization from ethyl acetate/ether.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1796-84-5, its application will become more common.

Reference:
Patent; Abbott Laboratories; US5486525; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1796-84-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1796-84-5, name is 4-Ethoxy-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 4: 1-N,N-Dimethylcarbamoyl-4-methoxycarbonyl-3-[5-(N-3-nitropyridin-4-yl)aminomethylthien-2-oyl]indole. To a solution of 1-N,N-dimethylcarbamoyl4-methoxycarbonyl-3-(5-aminomethylthien-2-oyl)indole (0.896 g, 2.33 mmol) in CH3 CN (5 mL) was added 4-ethoxy-3-nitropyridine (0.428 g, 2.55 mmol) and the reaction mixture was heated at reflux for 17 hours, then the solvent was removed in vacuo and the residue heated at 100 C. for 2 hours. The reaction mixture was then put under high vacuum to give 1-N,N-dimethylcarbamoyl-4-methoxycarbonyl-3-[5-(N-3-nitropyridin-4-yl)aminomethylthien-2-oyl]indole as a brown foam which was used without further purification.

According to the analysis of related databases, 1796-84-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Abbott Laboratories; US5486525; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem