Category: 17997-47-6

Related Products of 17997-47-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17997-47-6, name is 2-(Tributylstannyl)pyridine, molecular formula is C17H31NSn, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-tri-n-butylstannylpyridine (18.4 g, 0.05 mol), 1,5-dibromo-2,4-dimethyl-benzene (5.3 g, 0.02 mol), bis(triphenylphosphine) palladium(II) chloride (0.28 g, 0.4 mmol) and lithium chloride (6.4 g, 0.15 mol) in dry toluene (50 mL) was heated at 116 C under N2 for 24 h. After the reaction mixture cooled to room temperature, saturated KF solution (50 mL) was added and the solution stirred for 30 min. The precipitated solid was removed by filtration and washed with water (50 mL). NaHCO3 solution (10%, 150 mL) was then added to the combined filtrates, extracted with dichloromethane (3×200 mL), and dried over MgSO4. Removal of solvent under reduced pressure and purification of the residue by column chromatography (silica, hexane/dichloromethane=8:1; V/V) gave the desired product as a pale yellow solid (3.62 g, 69%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17997-47-6, 2-(Tributylstannyl)pyridine.

Reference:
Article; Tan, Shuai; Wu, Xiugang; Zheng, Yanqiong; Wang, Yafei; Chinese Chemical Letters; vol. 30; 11; (2019); p. 1951 – 1954;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 17997-47-6, Adding some certain compound to certain chemical reactions, such as: 17997-47-6, name is 2-(Tributylstannyl)pyridine,molecular formula is C17H31NSn, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17997-47-6.

A high-pressure vial was filled with the (S)-1-(4-bromobenzyl)-N-(1-(4-nitrophenyl)ethyl)- 1H-indole-5-carboxamide (37 mg, 0,08 mmol, 1 equiv), 2-(tributylstannyl)pyridine (28 muL, 0.09 mmol, 1.1 equiv), LiCl (10 mg, 0.24 mmol, 3 equiv), Pd(PPh3)4(9 mg, 0.008 mmol, 0.1 equiv), and anhydrous DMF (1 mL). The mixture was degassed for 5 min under argon atmosphere and the vial was sealed. The reaction mixture was heated at 120C for 1 h under microwaves. The solution was then concentrated in vacuo, filtered and purified by preparative HPLC to afford a beige powder (18 mg, 0.4 mmol, 50%). ESI-MS (m/z): 477 [M+H]+.

According to the analysis of related databases, 17997-47-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITY OF TOLEDO; GRIFFIN, Patrick R.; KAMENECKA, Theodore Mark; LECKA-CZERNIK, Beata; WO2015/161108; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 17997-47-6, 2-(Tributylstannyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(Tributylstannyl)pyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 2-(Tributylstannyl)pyridine

A mixture of (S)-2-( 1 -(2-chloro-7-fluoroquinolin-3 -yl)ethyl)isoindoline- 1,3 -dione (85.6 g, 241 mmol), Pd(PPh3)4 (14 g, 12.1 mmol, 0.O5eq) and 2-(tributylstannyl)pyridine (107 g, 289 mmol, 1.2 eq) in dioxane (3.0 L) was heated to 90 C under N2 overnight, then heated to 101 C for additional 2 days. The reaction mixture was cooled to room temperature, decanted and the final 200 mL solution was filtered. The combined solvents were concentrated to 300 mL and filtered to give a tan solid, which was washed with EtOAc/hexane (1/1) and dried (82.1 g). The mother liquor was concentrated to 100 mL and treated with EtOAc/hexane, 1/1 (200 mL) to give additional 2.2 g tan solid, overall 84.3 g.

The synthetic route of 17997-47-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; KELLY, Ron, C.; WORTMAN, Sarah; WO2015/171725; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem