1802-20-6 | Pyridine-derivatives

Extracurricular laboratory: Synthetic route of 1802-20-6

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1802-20-6, 3-Pentylpyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1802-20-6, name is 3-Pentylpyridine, molecular formula is C10H15N, molecular weight is 149.23, as common compound, the synthetic route is as follows.Recommanded Product: 1802-20-6

1,12-Dibromododecane (0.20 g, 0.61 mmol) was dissolved in 4-methyl-2- pentanone (2.0 ml) and 3-pentylpyridine (0.20 g, 1.34 mmol) was added. The mixture was 5 stirred at reflux for 20 h under a nitrogen atmosphere, and the solvent was removed under reduced pressure. The crude was triturated with Et2O (8 x 10 ml), and the solvent was removed under reduced pressure. The residue was purified by Al2O3 chromatography (neutral, activity H-III)5 using gradient elution (starting with CHCl3/MeOH = 2 % to 10 %). The residue was passed down a column of Lewatit MP-64 anion resin (Cl”), eluting with EtOH. The resulting fractions were combined and the solvent removed under reduced pressure to give the above compound as a light yellow waxy oil (0.28 g, 85 %).5 1H NMR (300 MHz, CDCl3): delta 9.55 (4H, m, CH(2′,6′)), 8.20 (2H, d, J= 6.5 Hz, CH(4′)), 8.07 (2H3 m, CH(3′)), 5.00 (4H5 m5 CH2(I)), 3.10 (4H5 m, CH2(I”)), 2.89 (4H5 m, CH2(2″))5 2.06 (4H5 m5 CH2(2))5 1.72 (4H5 m5 CH2(3″))5 1.33 (12H5 m, CH2(354,4″)), 1.33 (8H5 m, CH2(5,6)), 0.96 (6H, m, CH3(5″)). 13C NMR (300 MHz, CDCl3): 164.2, 144.2, 128.5, 61.2, 35.6, 32.2, 31.4, 29.5, 29.4, 29.1, 26.2, 22.4, 13.3, 1 signal obscured or io overlapping. MS: m/z ESI (positive ion) 233 [M-2C1″]2+ (18 %), 465 [M-2Cl”-H+]+ (10). Found [M-2C1″]2+ 233.2136, [C16H27N]2+ requires 233.2144.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1802-20-6, 3-Pentylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; THE UNIVERSITY OF SYDNEY; WO2007/128059; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 1802-20-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1802-20-6, its application will become more common.

Electric Literature of 1802-20-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1802-20-6 as follows.

EXAMPLE 112 Bromine (2.3 mL, 44.6 mmol) was added dropwise to a suspension of the 6-aminonicotinic acid Compound 112a (5.08 g, 36.8 mmol) in water (20 mL) at 4 C. After the completion of the addition, the cooling bath was removed and the reaction mixture was stirred at room temperature for 4.5 h. Saturated Na2S2O5 was added slowly to the stirred mixture. The solid was collected through filtration, washed with water, and dried under vacuum overnight to give 9.30 g of 6-amino-5-bromonicotinic acid along with 3,5-dibromo-2-aminopyridine in 1:1 ration as a greenish solid; MS (ES) m/z: 217 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1802-20-6, its application will become more common.

Reference:
Patent; Kuo, Gee-Hong; Connolly, Peter J.; Prouty, Catherine; DeAngelis, Alan; Wang, Aihua; Jolliffe, Linda; Middleton, Steve; Emanuel, Stuart; US2003/60629; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 1802-20-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1802-20-6, its application will become more common.