Category: 182924-36-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 182924-36-3, name is 5-(Bromomethyl)-2-chloropyridine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H5BrClN

To a solution of 323 mg (1.10 mmol) of (2-AMINO-5-PROPARGYLOXY-PHENYL)-4- isopropyl-phenyl) -methanone and 250 mg (1.21 mmol) of 2-bromomethyl-2-chloro- pyridine (step A) in 2 ml 1, 3-dimethyl-2-imidazolidinone (DMEU) 213 mg (1.54 mmol) of potassium carbonate are added. The reaction is complete after stirring for 2 h at 60 C. The cooled yellow suspension is distributed between ethyl acetate and bicarbonate solution. Flash chromatography (hexane/ethyl acetate) affords a yellow solid. m. p. 96 C. ‘H-NMR (300 MHz, CDC13) : 8.49 (t, 1H), 8.40 (d, 1H), 7.67 (dd, 1H), 7.61 (d, 2H), 7.31 (d, 2H), 7.30 (d, 1H), 7.23 (d, 1H), 7.08 (dd, 1H), 6.59 (d, 1H), 4.53 (d, 2H), 4.48 (d, 2H), 2.99 (HEPT, 1H), 2.48 (t, 1H), 1.31 (d, 6H). MS: 419 (M+L)

The synthetic route of 182924-36-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/56365; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 182924-36-3, name is 5-(Bromomethyl)-2-chloropyridine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H5BrClN

To a solution of 323 mg (1.10 mmol) of (2-AMINO-5-PROPARGYLOXY-PHENYL)-4- isopropyl-phenyl) -methanone and 250 mg (1.21 mmol) of 2-bromomethyl-2-chloro- pyridine (step A) in 2 ml 1, 3-dimethyl-2-imidazolidinone (DMEU) 213 mg (1.54 mmol) of potassium carbonate are added. The reaction is complete after stirring for 2 h at 60 C. The cooled yellow suspension is distributed between ethyl acetate and bicarbonate solution. Flash chromatography (hexane/ethyl acetate) affords a yellow solid. m. p. 96 C. ‘H-NMR (300 MHz, CDC13) : 8.49 (t, 1H), 8.40 (d, 1H), 7.67 (dd, 1H), 7.61 (d, 2H), 7.31 (d, 2H), 7.30 (d, 1H), 7.23 (d, 1H), 7.08 (dd, 1H), 6.59 (d, 1H), 4.53 (d, 2H), 4.48 (d, 2H), 2.99 (HEPT, 1H), 2.48 (t, 1H), 1.31 (d, 6H). MS: 419 (M+L)

The synthetic route of 182924-36-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/56365; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 182924-36-3, name is 5-(Bromomethyl)-2-chloropyridine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H5BrClN

To a solution of 323 mg (1.10 mmol) of (2-AMINO-5-PROPARGYLOXY-PHENYL)-4- isopropyl-phenyl) -methanone and 250 mg (1.21 mmol) of 2-bromomethyl-2-chloro- pyridine (step A) in 2 ml 1, 3-dimethyl-2-imidazolidinone (DMEU) 213 mg (1.54 mmol) of potassium carbonate are added. The reaction is complete after stirring for 2 h at 60 C. The cooled yellow suspension is distributed between ethyl acetate and bicarbonate solution. Flash chromatography (hexane/ethyl acetate) affords a yellow solid. m. p. 96 C. ‘H-NMR (300 MHz, CDC13) : 8.49 (t, 1H), 8.40 (d, 1H), 7.67 (dd, 1H), 7.61 (d, 2H), 7.31 (d, 2H), 7.30 (d, 1H), 7.23 (d, 1H), 7.08 (dd, 1H), 6.59 (d, 1H), 4.53 (d, 2H), 4.48 (d, 2H), 2.99 (HEPT, 1H), 2.48 (t, 1H), 1.31 (d, 6H). MS: 419 (M+L)

The synthetic route of 182924-36-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/56365; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 182924-36-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 182924-36-3, name is 5-(Bromomethyl)-2-chloropyridine, molecular formula is C6H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-(6-chloro-3-pyridyl)methyl-1,4,5,6-tetrahydropyrimidine [Compound 27] To an ice-cooled solution of 384 mg (4.6 mmol) of 1,4,5,6-tetrahydropyrimidine in 5 ml of acetonitrile was added 619 mg (3 mmol) of 5-bromomethyl-2-chloropyridine, and the mixture was stirred for 15 minutes. After removal of solvent under reduced pressure, 6 ml of the solution of 0.5N potassium hydroxide in ethanol was added to the residue. The insoluble matter was removed off by filtration, and the filtrate was concentrated under reduced pressure. The resulting residue was dissolved in toluene, and the solvent was removed again under reduced pressure. The resulting residue was purified by aminopropyl-coated silica gel (Chromatorex NH-type; Fuji Silysia Chemical Ltd.) column chromatography (eluent; dichloromethane_methanol=40:1) to give 221 mg (yield; 35.2%) of 1-(6-chloro-3-pyridyl)methyl-1,4,5,6-tetrahydropyrimidine as colorless oil.

According to the analysis of related databases, 182924-36-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Imoto, Masahiro; Iwanami, Tatsuya; Akabane, Minako; Tani, Yoshihiro; US2003/100769; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem