Synthetic Route of 183208-35-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 183208-35-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below.
[0653] To a stirred solution of 5-bromo-1H-pyrrolo [2, 3-bj pyridine (2 g, 10 mmol) in DMSO (20 mL) at room temperature under an argon atmosphere were added potassium hydroxide (852 mg, 15 mmol) and methyl iodide (1.95 mL, 30 mmol). The reaction mixture was warmed to room temperature and stirred for 4 h. After consumption of starting material (by TLC), the reaction mixture was diluted with ice cold water (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filteredand concentrated in vacuo to obtain 5-bromo-1-methyl-1H-pyrrolo [2, 3-bj pyridine (2.1 g, crude) as colorless syrup used in the next step without further purification.LCMS: 98.9%; 212.7 (M+3); (column; Ascentis Express C-18 (50 x 3.0 mm, 2.7 jtm); RT 2.49 mm; mobile phase: 0.025% Aq TFA+5% ACN: ACN+5% 0.025% Aq TFA; T/B%:0.01/5, 0.5/5, 3/100, 5/100; flow rate: 1.2 mL/min) (Gradient); TLC: 30% EtOAc/ Hexane (R1: 0.6).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183208-35-7, its application will become more common.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; HARRISON, Bryce, Alden; (273 pag.)WO2017/31325; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem