Category: 183483-29-6

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 183483-29-6, name is 2-(2-Bromopyridin-4-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-(2-Bromopyridin-4-yl)acetic acid

To a solution of 2-(2-bromo-4-pyridyl)acetic acid (300 mg, 1.39 mmol), diisopropylethylamine (538 mg, 4.17 mmol) and HATU (634 mg, 1.67 mmol) in DCM (15 mL) was added ethyl 2-amino-2-methyl-propanoate (256 mg, 1.53 mmol, HCl salt) and the reaction mixture was stirred at 20 C for 16 hours. On completion, the reaction mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate = 1:1) to give the title compound (430 mg, 94% yield) as a light yellow solid. LCMS: (ES+) m/z (M+H)+= 329.0, tR = 0.679.1H NMR (400MHz, CDCl3) delta = 8.33 (d, J = 5.2 Hz, 1H), 7.45 (d, J = 1.2 Hz, 1H), 7.22 (dd, J = 1.2, 5.2 Hz, 1H), 6.27 (br. s., 1H), 4.20 (q, J = 7.2 Hz, 2H), 3.49 (s, 2H), 1.57 (s, 6H), 1.26 (t, J = 7.2 Hz, 3H)

With the rapid development of chemical substances, we look forward to future research findings about 183483-29-6.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (215 pag.)WO2018/106636; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 183483-29-6, name is 2-(2-Bromopyridin-4-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-(2-Bromopyridin-4-yl)acetic acid

To a solution of 2-(2-bromo-4-pyridyl)acetic acid (300 mg, 1.39 mmol), diisopropylethylamine (538 mg, 4.17 mmol) and HATU (634 mg, 1.67 mmol) in DCM (15 mL) was added ethyl 2-amino-2-methyl-propanoate (256 mg, 1.53 mmol, HCl salt) and the reaction mixture was stirred at 20 C for 16 hours. On completion, the reaction mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate = 1:1) to give the title compound (430 mg, 94% yield) as a light yellow solid. LCMS: (ES+) m/z (M+H)+= 329.0, tR = 0.679.1H NMR (400MHz, CDCl3) delta = 8.33 (d, J = 5.2 Hz, 1H), 7.45 (d, J = 1.2 Hz, 1H), 7.22 (dd, J = 1.2, 5.2 Hz, 1H), 6.27 (br. s., 1H), 4.20 (q, J = 7.2 Hz, 2H), 3.49 (s, 2H), 1.57 (s, 6H), 1.26 (t, J = 7.2 Hz, 3H)

With the rapid development of chemical substances, we look forward to future research findings about 183483-29-6.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (215 pag.)WO2018/106636; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 183483-29-6, name is 2-(2-Bromopyridin-4-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

2-(2-bromopyridin-4-yl)acetic acid (0.9685 g, 4.48 mmol) was dissolved in a mixture of toluene (20 ml)/MeOH (2.50 ml) then cooled to 0C. Trimethyl- silyldiazomethane (5.60 ml, 11.21 mmol) was added. The reaction was stirred at 0C for 1 hr then concentrated to yield methyl 2-(2-bromopyridin-4-yl)acetate. LC/MS [M+H]+: 231.4

With the rapid development of chemical substances, we look forward to future research findings about 183483-29-6.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TANG, Haifeng; YANG, Shu-Wei; MANDAL, Mihir; SU, Jing; LI, Guoqing; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; PAN, Jianping; HAGMANN, William; DING, Fa-Xiang; XIAO, Li; PASTERNAK, Alexander; HUANG, Yuhua; DONG, Shuzhi; YANG, Dexi; WO2015/171474; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 183483-29-6, name is 2-(2-Bromopyridin-4-yl)acetic acid, the common compound, a new synthetic route is introduced below. Product Details of 183483-29-6

2-(2-Bromopyridin-4-yl)acetic acid (5 g, 23.1 mmol), benzene (40.5 ml) and MeOH (5.8 ml) were added to a 250 mL flask, thentrimethylsilyldiazomethane (11.6 ml, 23.1 mmol, 2 M) was added dropwise over 5 mm. The reaction was concentrated in vacuo. Silica gel chromatography using a hexanes/EtOAc gradient (0-100%) afforded the title compound.

The synthetic route of 183483-29-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAN, Xiaoqing; WHITEHEAD, Alan; RAGHAVAN, Subharekha; GROEPER, Jonathan; GUO, Jian; ZHANG, Yong; WO2015/88885; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 183483-29-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.183483-29-6, name is 2-(2-Bromopyridin-4-yl)acetic acid, molecular formula is C7H6BrNO2, molecular weight is 216.03, as common compound, the synthetic route is as follows.

c) (2-Bromo-pyridin-4-yl)-acetic acid ethyl esterTo a solution of (2-bromo-pyridin-4-yl)-acetic acid (60.0 g, 277.7 mmol) in ethanol (600 ml), conc: sulfuric acid (5.0 ml) was added at rt and the reaction mixture was heated at 90 C. for 9 h. Reaction mixture was cooled to rt and concentrated under reduced pressure to remove solvent completely. The residue obtained was cooled to 0 C. and pH was adjusted to 8 using 10% aqueous NaHCO3 solution. The resultant contents were worked up with ethyl acetate by washing with water, brine and dried over anhy. Na2SO4. Organic layer was concentrated under reduced pressure to obtain crude compound. Column chromtography purification of the crude compound using 15% ethyl acetate in hexane as eluent furnished title compound as a brown oil. Yield: 65.0 g (88.5%). TLC (30% ethyl acetate in hexane) Rf=0.39; LCMS: RtH7=0.824 [M+1]+=243.8 and 245.8; HPLC RtH9=3.759 min (69%); 1H NMR (300 MHz, CDCl3): delta 8.32 (t, 1H), 7.43 (s, 1H), 7.21-7.15 (M, 1H), 4.18 (q, 2H), 1.27 (t, 3H).

The chemical industry reduces the impact on the environment during synthesis 183483-29-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BADIGER, Sangamesh; CHEBROLU, Murali; HURTH, Konstanze; JACQUIER, Sebastien; LUEOEND, Rainer Martin; MACHAUER, Rainer; RUEEGER, Heinrich; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus; US2012/184539; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem