Category: 1835671-08-3

Lux, Michaelyn C. et al. published new progress in experiments with the help of cas: 1835671-08-3

N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole(cas: C15H11F3N2O) can also undergo this reaction.

Name: (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole《Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction》 was published in 2019. The authors were Lux, Michaelyn C.;Boby, Melissa L.;Brooks, Joshua L.;Tan, Derek S., and the article was included in《Chemical Communications (Cambridge, United Kingdom)》. The author mentioned the following in the article:

Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates [e.g., I → II, (60% isolated) with complete cis-diastereoselectivity at ring junction and 4:1 dr (α/β) at vinyl side chain]. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion.(R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1835671-08-3) were involved in the experimental procedure.

N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole(cas: C15H11F3N2O) can also undergo this reaction.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Junjie et al. published new progress in experiments with the help of cas: 1835671-08-3

N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole(cas: C15H11F3N2O) can also undergo this reaction.

COA of Formula: C15H11F3N2OIn 2017, Chen, Junjie;Han, Xiuling;Lu, Xiyan published 《Atom-Economic Synthesis of Pentaleno[2,1-b]indoles via Tandem Cyclization of Alkynones Initiated by Aminopalladation》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:

An atom-economic Pd(OAc)2-catalyzed tandem cyclization of alkynones to synthesize pentaleno[2,1-b]indoles was developed efficiently. In the formed tetracyclic indole framework, two neighboring stereocenters, one being all-carbon quaternary, are constructed in a single process with excellent diastereoselectivity. This reaction was initiated by aminopalladation of alkynes and quenched by addition to the intramol. carbonyl groups. To complete the study, the researchers used (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1835671-08-3) .

N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole(cas: C15H11F3N2O) can also undergo this reaction.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem