Category: 183610-70-0

Related Products of 183610-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

3-(trifluoromethyl)pyridin-2-amine (0.15 g, 0.92 mmol) was added to a mixture of sodium hydride (0.14 g, 5.5 mmol) and N,N-dimethylformamide (3.0 ml_) under nitrogen gas at 15 – 20 C and the reaction mixture was stirred for 15 – 20 min. Compound of example 65 (0.248 g, 1 .06 mmol) was added to the reaction mixture at 5 – 10 C and was stirred for 3 – 6 h. The reaction mixture was cooled to 10 C and methanol (0.5 ml_) was added slowly. A solution of chilled 20 % ammonium chloride solution (4.5 ml_) was added drop-wise to the reaction mixture at 10 C and was stirred for 25 – 30 min. The product was extracted in ethyl acetate (12 ml_) and the organic layer was dried over anhydrous sodium sulphate. The solvent was evaporated to obtain the crude product, which was further purified by column chromatography to obtain the title compound. Yield: 0.07 g (21 %); 1H NMR (300 MHz, DMSO-d6): delta 9.0 (s, 1 H), 8.74 (m, 2H), 8.36 (d, 1 H), 7.80 (s, 1 H), 7.61 (m, 2H), 7.42 (m, 1 H), 7.10 (d, 1 H), 6.1 (s, 2H); MS (ES+): 361 .4 (M+1 ).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana, Sanjay; HARIHARAN, Sivaramakrishnan; BOKKA, Ravishankar; AWARE, Valmik, Sopan; MANOHAR, Sonal; SONAWANE, Vinay; CHENNAMSETTY, Suneelmanoharbabu; KALE, Ganesh; THOMAS, Becky, Mary; TRIVEDI, Jacqueline, Vinodkumar; WO2013/175415; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 183610-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

3-(trifluoromethyl)pyridin-2-amine (0.15 g, 0.92 mmol) was added to a mixture of sodium hydride (0.14 g, 5.5 mmol) and N,N-dimethylformamide (3.0 ml_) under nitrogen gas at 15 – 20 C and the reaction mixture was stirred for 15 – 20 min. Compound of example 65 (0.248 g, 1 .06 mmol) was added to the reaction mixture at 5 – 10 C and was stirred for 3 – 6 h. The reaction mixture was cooled to 10 C and methanol (0.5 ml_) was added slowly. A solution of chilled 20 % ammonium chloride solution (4.5 ml_) was added drop-wise to the reaction mixture at 10 C and was stirred for 25 – 30 min. The product was extracted in ethyl acetate (12 ml_) and the organic layer was dried over anhydrous sodium sulphate. The solvent was evaporated to obtain the crude product, which was further purified by column chromatography to obtain the title compound. Yield: 0.07 g (21 %); 1H NMR (300 MHz, DMSO-d6): delta 9.0 (s, 1 H), 8.74 (m, 2H), 8.36 (d, 1 H), 7.80 (s, 1 H), 7.61 (m, 2H), 7.42 (m, 1 H), 7.10 (d, 1 H), 6.1 (s, 2H); MS (ES+): 361 .4 (M+1 ).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana, Sanjay; HARIHARAN, Sivaramakrishnan; BOKKA, Ravishankar; AWARE, Valmik, Sopan; MANOHAR, Sonal; SONAWANE, Vinay; CHENNAMSETTY, Suneelmanoharbabu; KALE, Ganesh; THOMAS, Becky, Mary; TRIVEDI, Jacqueline, Vinodkumar; WO2013/175415; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., Formula: C6H5F3N2

To a stirred solution of R-10 (2.70 g, 16.66 mmol) in DMF (15 ml) is added N- bromosuccinimide (3.00 g, 16.85 mmol) as a DMF solution (15 ml, dropwise). After 4 h the reaction is poured onto ice. The resulting precipitate is collected via filtration to give the product as an off-white solid. Dissolved into DCM and washed with brine. The layers are separated and the organic phase is dried (MgS04), filtered and concentrated to give the title intermediate (3.8 g); m/z 241.2/243.2 [M/M+2H] .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John; LO, Ho Yin; LOKE, Pui Leng; LIU, Weimin; MORWICK, Tina Marie; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee; WO2012/24150; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., name: 2-Amino-3-(trifluoromethyl)pyridine

To a solution of 5.37 g (32.8 mmol) of 3-trifluoromethyl-pyridin-2-ylamine (Fluorochem Ltd., Derbyshire, United Kingdom) in 100 ml of dry CH3CN, 6.45 g of NBS are added in 4 equal portions over a period of 1 h at 0-50C under argon. The cooling bath is removed and stirring is continued for 3 h. The solvent is evaporated under vacuum, the residue is dissolved in EtOAc and washed with water and brine. The organic phase is dried over Na2SO4 and evaporated. The title compound is a red-dish-yellow oil which is used after drying in the dark for 5 h at RT and under high vacuum in the next step without further purification. ES-MS (M+1 ): = 239; 241 ; HPLC: tR = 5.501 min. Example 1.4 1 -(2-Methoxy-pyridin-3-yl)-3-methyl-8-(6-methylamino-pyridin-3-yl)-1 ,3-dihydro- imidazo[4,5-c]quinolin-2-one

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; IMBACH, Patricia; MAH, Robert; STAUFFER, Frederic; WO2010/139747; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 183610-70-0

In a 7 ml screw cap vial 1,1-dimethylethyl (2S)-2-(3-bromo-2-oxopropyl)-1-piperidinecarboxylate D2 (0.10 g, 0.31 mmol), DMF (1 ml) and 3-(trifluoromethyl)-2-pyridinamine (0.076 g, 0.47 mmol) were added and the resulting mixture stirred at 80 C. for 13 h. The mixture was eluted through a SCX column. Collected fractions gave 0.15 g of a crude containing the title compound D7, the corresponding free amine and some residual 3-(trifluoromethyl)-2-pyridinamine. The material was used in the next step without further purification. HPLC (walk-up): rt=3.79 min. MS: (ES/+) m/z: 384 (M+1). C19H24F3N3O2 requires 383.

With the rapid development of chemical substances, we look forward to future research findings about 183610-70-0.

Reference:
Patent; ALVARO, GIUSEPPE; AMANTINI, DAVID; BELVEDERE, SANDRO; US2009/22670; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Amino-3-(trifluoromethyl)pyridine

A mixture of 3-(trifluoromethyl)pyridin-2-amine (3.00 g, 18.5 mmol), 1- bromobutan-2-one (3.76 g, 24.9 mmol), sodium hydrogencarbonate (3.11 g, 37.0 mmol) and sodium iodide (0.832 g, 5.55 mmol) in ethanol (37 mL) was refluxed overnight. The ethanol was removed in vacuo and the resulting material was treated with water and extracted with ethyl acetate. The combined organics were dried over MgSO4 and concentrated. The product was chromatographed using a 0:100 to 50:50 E:H gradient to afford the title compound as a white solid (2.92, 74%). MS (ES) m/z 215.1

With the rapid development of chemical substances, we look forward to future research findings about 183610-70-0.

Reference:
Patent; WYETH; WO2009/86123; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

183610-70-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-trifluoromethylpyridin-2-ylamine (Fluorochem Ltd , Derbyshire, United Kingdom 5 37 g, 32 8 mmol) in 100 ml of dry CH3CN under argon were added N- bromosuccinimide (645 g, 36 2 mmol) in 4 equal portions over a period of 1 h at 0-5C The cooling bath was removed and stirring was continued for 3 h The solvent was evaporated under vacuum, then the residue was dissolved in EtOAc and washed with water and brine The organic layer was dned over Na?SO and evaporated to give the title compound as a orange oil. (M+H = 239, 241).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; KALTHOFF, Frank Stephan; MAH, Robert; RAGOT, Christian; STAUFFER, Frederic; WO2010/139731; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem