Louw, Stefan’s team published research in Journal of Chromatography A in 1217 | CAS: 18437-58-6

Journal of Chromatography A published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Safety of 4-Amino-2-picoline.

Louw, Stefan published the artcileHigh-efficiency hydrophilic interaction chromatography by coupling 25 cm × 4.6 mm ID × 5 μm silica columns and operation at 80°C, Safety of 4-Amino-2-picoline, the publication is Journal of Chromatography A (2010), 1217(4), 514-521, database is CAplus and MEDLINE.

Recently, hydrophilic interaction chromatog. (HILIC) has emerged as a valuable orthogonal tool to reversed-phase liquid chromatog. (RP-LC) as it allows for resolution of highly polar ionisable compounds The relationships between separation efficiency, column length and speed of anal. for 4.6 mm ID × 5 μm silica particle columns in HILIC are demonstrated using kinetic plots. The kinetic plots constructed for conventional pressure systems operating at 350 bar and at 30° and 80° are confirmed using exptl. data for different column lengths. Efficiencies of more than 130,000 theor. plates could be achieved by connecting up to six columns of 25 cm. As expected, a significant gain in anal. speed without loss of efficiency could be obtained by operating at 80° compared to 30°. The advantages of using long columns in HILIC in combination with elevated column temperature for the pharmaceutical industry are illustrated using test mixtures comprised of com. available ionisable compounds (including some containing functional groups with potential genotoxic typical structural alerts) as well as real polar ionisable pharmaceuticals.

Journal of Chromatography A published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Safety of 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pavia, Michael R.’s team published research in Journal of Medicinal Chemistry in 33 | CAS: 18437-58-6

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.

Pavia, Michael R. published the artcileN-Phenyl-N’-pyridinylureas as anticonvulsant agents, Recommanded Product: 4-Amino-2-picoline, the publication is Journal of Medicinal Chemistry (1990), 33(2), 854-61, database is CAplus and MEDLINE.

A series of N-phenyl-N‘-pyridinylureas, e.g., I (R, R1, R2, R3 = H, Cl, Br, F, CF3, Me, Et, CHMe2, NO2, NH2, OMe, etc.) was prepared by the reaction of aryl isocyanates with 2-, 3-, of 4-aminopyridine. They were examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2,6-disubstituted-phenyl)-N‘-(4-pyridinyl)urea series, with I (R = Cl, R1 = R2 = H, R3 = Me) (II) exhibiting the best overall anticonvulsant profile. II was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacol. profile suggests that II would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. II was selected for Phase 1 clin. trials.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tite, Tony’s team published research in Synlett in | CAS: 18437-58-6

Synlett published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C14H18BNO2S, HPLC of Formula: 18437-58-6.

Tite, Tony published the artcileThe synthesis of 6-deazaformycin A, HPLC of Formula: 18437-58-6, the publication is Synlett (2009), 2927-2930, database is CAplus.

The synthesis of the new C-nucleoside 6-deazaformycin A was achieved through: the condensation of a suitably substituted lithiated 2-picoline with 2,3,5-tri-O-benzyl-D-ribonolactone; borohydride reduction of the resulting hemiacetals; followed by intramol. Mitsunobu cyclization of the carbinols; manipulation of the protecting groups, and subsequent ring closure to result in the formation of 7-amino-3-(β-D-ribofuranosyl)pyrazolo[4,3-b]pyridine.

Synlett published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C14H18BNO2S, HPLC of Formula: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ovchinnikov, V. G.’s team published research in Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) in 62 | CAS: 18437-58-6

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Quality Control of 18437-58-6.

Ovchinnikov, V. G. published the artcileCatalytic hydrogenation of 4-nitro-2-methylpyridine N-oxide, Quality Control of 18437-58-6, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) (1989), 62(7), 1577-86, database is CAplus.

Catalytic hydrogenation of 4-nitro-2-methylpyridine N-oxide (I) at high pressures and temperatures in low-boiling organic solvents gave 90-98% yields of 4-amino-2-methylpyridine (II). Similar hydrogenations at atm. pressure and room temperature gave mixtures of variously reduced products. Thus, hydrogenation of I over Ni/kieselguhr at 120°, 110 atm, 1 h in Me2CO gave 98% II.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Quality Control of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, Zi-Zhen’s team published research in Journal of Biological Chemistry in 284 | CAS: 18437-58-6

Journal of Biological Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C9H6N2O4, Application In Synthesis of 18437-58-6.

Wu, Zi-Zhen published the artcileAminopyridines Potentiate Synaptic and Neuromuscular Transmission by Targeting the Voltage-activated Calcium Channel β Subunit, Application In Synthesis of 18437-58-6, the publication is Journal of Biological Chemistry (2009), 284(52), 36453-36461, database is CAplus and MEDLINE.

Aminopyridines such as 4-aminopyridine (4-AP) are widely used as voltage-activated K+ (Kv) channel blockers and can improve neuromuscular function in patients with spinal cord injury, myasthenia gravis, or multiple sclerosis. Here, we present novel evidence that 4-AP and several of its analogs directly stimulate high voltage-activated Ca2+ channels (HVACCs) in acutely dissociated neurons. 4-AP, 4-(aminomethyl)pyridine, 4-(methylamino)pyridine, and 4-di(methylamino)pyridine profoundly increased HVACC, but not T-type, currents in dissociated neurons from the rat dorsal root ganglion, superior cervical ganglion, and hippocampus. The widely used Kv channel blockers, including tetraethylammonium, α-dendrotoxin, phrixotoxin-2, and BDS-I, did not mimic or alter the effect of 4-AP on HVACCs. In HEK293 cells expressing various combinations of N-type (Cav2.2) channel subunits, 4-AP potentiated Ca2+ currents primarily through the intracellular β3 subunit. In contrast, 4-AP had no effect on Cav3.2 channels expressed in HEK293 cells. Furthermore, blocking Kv channels did not mimic or change the potentiating effects of 4-AP on neurotransmitter release from sensory and motor nerve terminals. Thus, our findings challenge the conventional view that 4-AP facilitates synaptic and neuromuscular transmission by blocking Kv channels. Aminopyridines can directly target presynaptic HVACCs to potentiate neurotransmitter release independent of Kv channels.

Journal of Biological Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C9H6N2O4, Application In Synthesis of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hoyt, Caroline B.’s team published research in Advanced Synthesis & Catalysis in 359 | CAS: 18437-58-6

Advanced Synthesis & Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Name: 4-Amino-2-picoline.

Hoyt, Caroline B. published the artcileSelective C(sp3)-H Monoarylation Catalyzed by a Covalently Cross-Linked Reverse Micelle-Supported Palladium Catalyst, Name: 4-Amino-2-picoline, the publication is Advanced Synthesis & Catalysis (2017), 359(20), 3611-3617, database is CAplus.

In this work, we illustrate the performance of a solvated micelle-supported ligand as a platform for coordination with palladium for C-H arylation. The micelle-supported ligand is one of the first applications of a micelle-supported ligand for C-H arylation, and provides a tunable support for future elaboration. The use of a spatially constrained system promoted selectivity trends influenced by both the sterics and electronics of the system, differing from the homogeneous catalyst, with high yields and selectivities.

Advanced Synthesis & Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Name: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Raboisson, Pierre’s team published research in Bioorganic & Medicinal Chemistry Letters in 17 | CAS: 18437-58-6

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Synthetic Route of 18437-58-6.

Raboisson, Pierre published the artcileEvaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors, Synthetic Route of 18437-58-6, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(7), 1843-1849, database is CAplus and MEDLINE.

Screening of a focused library of TGF beta kinase inhibitors in the cellular HCV replicon model with luciferase read out yielded a number of low micromolar HCV inhibitors. Medicinal chem. driven optimization resulted in the discovery of 4-[2-(5-bromo-2-fluoro-phenyl)pteridin-4-ylamino]-N-[3-(2- oxopyrrolidin-1-yl)propyl]nicotinamide 36 with a replicon EC50 of 64 nM, associated with a selective kinase inhibitory profile for human JNK kinases 2 and 3 as well as VEGFR-1, 2, and 3 kinases. Moreover, 36 showed an advantageous PK profile in mice. Experiments performed using different replicon constructs suggest that this series of kinase inhibitors might mediate their effect through the HCV non-structural protein 5A (NS5A).

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Synthetic Route of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wikaira, Jan L.’s team published research in Polyhedron in 52 | CAS: 18437-58-6

Polyhedron published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C4Br2N2O4S, Related Products of pyridine-derivatives.

Wikaira, Jan L. published the artcileTetrahalocuprate salts of substituted 4-aminopyridines: Synthesis, structure and magnetic properties, Related Products of pyridine-derivatives, the publication is Polyhedron (2013), 770-780, database is CAplus.

The reaction of CuX2 (X = Br or Cl) with 4-amino-2-chloropyridine or 4-amino-2-methylpyridine in aqueous acids (HX; X = Br or Cl) yields bis(4-amino-2-chloropyridinium) tetrachlorocuprate(II) 3, bis(4-amino-2-chloropyridinium) tetrabromocuprate(II) 4, bis(4-amino-2-methylpyridinium) tetrachlorocuprate(II) monohydrate 5, and bis(4-amino-2-methylpyridinium) tetrabromocuprate(II) monohydrate 6. These compounds were characterized by IR, powder x-ray diffraction, single crystal X-ray diffraction, combustion anal., and temperature dependent magnetic susceptibility. Compounds 3 and 4 both crystallize in the monoclinic space group C2/c, compounds 5 crystallizes in the monoclinic space group P21/c and compound 3 crystallizes in the triclinic space group P-1. Magnetic data were collected for the four synthesized compounds and their previously reported parent compounds of 4-aminopyridinium tetrachlorocuprate 1, or tetrabromocuprate 2. All compounds exhibit antiferromagnetic exchange via the two-halide exchange, with strongest exchange observed for compound 6. A number of potential magnetic exchange pathways are seen in these compounds, but fitting of the data to available anal. models suggests that the magnetic exchange constants are 2J/kB approx. -0.14(2) K in 1, �0.812(5) K in 2, �0.173(6) K in 3, �0.82(1) K in 4, �2.123(6) K in 5, and �30.9(1) K in 6.

Polyhedron published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C4Br2N2O4S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

den Hertog, H. J.’s team published research in Recueil des Travaux Chimiques des Pays-Bas et de la Belgique in 70 | CAS: 18437-58-6

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Computed Properties of 18437-58-6.

den Hertog, H. J. published the artcileDerivatives of pyridine and quinoline. LXXXIX. Derivatives of pyridine 1-oxide. IV. Directive influence of the 1-oxide group during the nitration of derivatives of pyridine 1-oxide, Computed Properties of 18437-58-6, the publication is Recueil des Travaux Chimiques des Pays-Bas et de la Belgique (1951), 591-9, database is CAplus.

3-Ethoxypyridine (I) is converted to 3-ethoxypyridine I-oxide phthalate (II), m. 83.5-4.5°, with o-HO2CC6H4CO3H in Et2O. II with fuming HNO3 and H2SO4 yields 3-ethoxy-4-nitropyridine 1-oxide (III), m. 134-5°, which with Fe powder in HOAc gives 3-ethoxy-4-aminopyridine (picrate, m. 194-5°; mono-Ac derivative, m. 112.5-13.0°). Oxidation and nitration of 2-ethoxypyridine yields g-ethoxy-4-nitropyridine 1-oxide, m. 132.5-3.5°, which was reduced to 4-amino-2-ethoxypyridine, m. 88-9° forms a mono-Ac derivative, m. 105-5.5°, whose picrate m. 161-2°. The mono-Ac derivative of 2-amino-3-ethoxypyridine (IV) is prepared from IV and ketene, while the di-Ac derivative, m. 57.5-8.0°, is obtained from IV with Ac2O at 215°. 2-Bromopyridine on oxidation and nitration yields 2-bromo-4-nitropyridine 1-oxide, m. 145.5-6.0°, reduced to 4-amino-2-bromopyridine, m. 95-7°. 2-Methylpyridine treated as above gives 2-methylpyridine 1-oxide phthalate, m. 115-16°, which on nitration yields 2-methyl-4-nitropyridine 1-oxide, m. 156-6.5°, reduced to 2-methyl-4-aminopyridine, m. 95.5-6°.

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Computed Properties of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Deady, Leslie W.’s team published research in Australian Journal of Chemistry in 35 | CAS: 18437-58-6

Australian Journal of Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, SDS of cas: 18437-58-6.

Deady, Leslie W. published the artcileSubstituent effects on the isomer ratios in the rearrangement of some 2- and 4-nitraminopyridines, SDS of cas: 18437-58-6, the publication is Australian Journal of Chemistry (1982), 35(10), 2025-34, database is CAplus.

The preparation and rearrangement in 92% H2SO4 of IIII (R = H, Me, MeO, Br, Cl, CO2H) were investigated. The product isomer ratios can be explained by differential electronic stabilization of the appropriate σ complexes for aromatic nitration and steric effects seem relatively unimportant. Deuteration [3-D in I, R = Me] had no effect on the product distribution.

Australian Journal of Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, SDS of cas: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem