Category: 18614-51-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18614-51-2, name is 4-Amino-2-fluoropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 4-Amino-2-fluoropyridine

In a 10 mL microwave vial, Pd2(dba)3 (21.61 mg, 0.024 mmol), cesium carbonate (77 mg, 0.236 mmol), 2-dicyclohexylphosphino-2?-(N,N-dimethylamino)-biphenyl (DavePhos, 18.58 mg, 0.047 mmol), 4-amino-2-fluoropyridine (8.82 mg, 0.079 mmol), and (R)-3-chloro-10-methyl-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5?,6?:4,5]thieno[3,2-f]quinolin-8-one (S1-12) (25 mg, 0.079 mmol) were dissolved in 0.5 mL of dry t-BuOH. The reaction was placed under vacuum then backfilled with nitrogen. The reaction was heated to 100 C. overnight then cooled, filtered and concentrated to dryness. The residue was redissolved in DMSO and purified by reverse phase HPLC with 95%-5% H2O (containing 0.5% TFA v/v)/acetonitrile to afford compound I-3 (0.004 g, 7.8 mumol, 10.0% yield). MS: m/z 393.6 (M+H), 391.7 (M-H). 1H NMR (400 MHz, DMSO-d6): delta 1.13 (d, 3H), 3.39 (m, 2H), 3.55 (m, 1H), 6.94 (br s, 1H), 7.20 (d, 1H), 7.81 (d, 1H), 7.99 (m, 4H), 9.02 (d, 1H), 10.21 (s, 1H).

The synthetic route of 18614-51-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Celgene Avilomics Research, Inc.; Alexander, Matthew David; Chuaqui, Claudio; Malona, John; McDonald, Joseph John; Ni, Yike; Niu, Deqiang; Petter, Russell C.; Singh, Juswinder; (164 pag.)US2016/75720; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 18614-51-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18614-51-2, name is 4-Amino-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

CuBr2 (0.1121 g, 0.501 mmol) was dissolved in 20 mL of 1-propanol and warmedfor 0.5 h to yield a dark brown mixture. 2-F-4AP (0.1141 g, 1.02 mmol) in 10 mL of 1-propanoland 1.2 mL of 48% HBr (aq) (8.84 M) was added to the CuBr2 solution. The dark brown, opaquesolution was left to evaporate at room temperature for three weeks. When the solutionreached 3 mL, the beaker was set in a desiccator. After six days, purple needles were recoveredby vacuum filtration, washed with cold 1-propanol and allowed to air dry to give 0.133 g(21.8%). IR (KBr) nu – 3387 m, 3302 m, 3203 m, 3089 m, 2964 m, 1663 s, 1604 m, 1523 m,1207 m, 1004 m, 831 w, and 738 m cm-1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18614-51-2, 4-Amino-2-fluoropyridine.

Reference:
Article; Krasinski, Claire A.; Solomon, Benjamin L.; Awwadi, Firas F.; Landee, Christopher P.; Turnbull, Mark M.; Wikaira, Jan L.; Journal of Coordination Chemistry; vol. 70; 5; (2017); p. 914 – 935;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 18614-51-2, 4-Amino-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 18614-51-2, blongs to pyridine-derivatives compound. Recommanded Product: 18614-51-2

Method A) CuCl2 (0.0680 g, 0.513 mmol) was dissolved in 3 mL of water to yield a blue,opaque solution. 2-F-4-AP (0.111 g, 0.991 mmol) in 5 mL of water was added to the CuCl2solution. The aquamarine, opaque solution was left to evaporate at room temperature forthree weeks. Dark green prisms were recovered by vacuum filtration, washed with cold waterand allowed to air dry to give 0.0612 g (13.7%). Single crystals (dark green needles) weregrown through recrystallization of the prisms from water over the course of a month. IR (KBr)nu – 3413 m, 3327 m, 3220 m, 3071w, 1639s, 1560 m, 1510 m, 1475 m, 1375s, 1267s, 1195 m,1026 m, 994 m, 834 m, 777 m, and 656w cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18614-51-2, its application will become more common.

Reference:
Article; Krasinski, Claire A.; Solomon, Benjamin L.; Awwadi, Firas F.; Landee, Christopher P.; Turnbull, Mark M.; Wikaira, Jan L.; Journal of Coordination Chemistry; vol. 70; 5; (2017); p. 914 – 935;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem