Category: 18653-75-3

Synthetic Route of 18653-75-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a mixture of 1.45 g (10 mmol) of 2-pyridyl-1H-imidazole, 0.62 g (11 mmol) of powdered KOH, and 10 mL of ethylene glycol dimethyl ether was added dropwise 0.68 g (11 mmol) of methyl iodide with vigorous stirring at 3-5 C, maintaining the reaction temperature no higher than 8 C. The mixture was stirred at this temperature for 0.5 h, and then poured into 100 mL of water. The reaction product was filtered off or extracted with chloroform (2×50 mL). The extract was dried over calcium chloride, chloroform was distilled off. The residue was extracted with hot hexane (3×50 mL) and evaporated to give the corresponding 1-methyl-2-pyridyl-1H-imidazole.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine.

Reference:
Article; El?chaninov; Aleksandrov; Klushin; Russian Journal of General Chemistry; vol. 86; 7; (2016); p. 1581 – 1583; Zh. Obshch. Khim.; vol. 86; 7; (2016); p. 1102 – 1105,3;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 18653-75-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a mixture of 1.45 g (10 mmol) of 2-pyridyl-1H-imidazole, 0.62 g (11 mmol) of powdered KOH, and 10 mL of ethylene glycol dimethyl ether was added dropwise 0.68 g (11 mmol) of methyl iodide with vigorous stirring at 3-5 C, maintaining the reaction temperature no higher than 8 C. The mixture was stirred at this temperature for 0.5 h, and then poured into 100 mL of water. The reaction product was filtered off or extracted with chloroform (2×50 mL). The extract was dried over calcium chloride, chloroform was distilled off. The residue was extracted with hot hexane (3×50 mL) and evaporated to give the corresponding 1-methyl-2-pyridyl-1H-imidazole.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine.

Reference:
Article; El?chaninov; Aleksandrov; Klushin; Russian Journal of General Chemistry; vol. 86; 7; (2016); p. 1581 – 1583; Zh. Obshch. Khim.; vol. 86; 7; (2016); p. 1102 – 1105,3;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine. A new synthetic method of this compound is introduced below., Computed Properties of C8H7N3

solid I (2.61 g, 18.0 mmol) was added to a solution of KOH in H2O (50%, 10 ml). 2-Chloromethyl ethyl ether (1.46 g, 15.4 mmol) was added dropwise and the reaction mixture was refluxed for 3.5 h. Water (10 ml) was added to the reaction mixture and the organic phase was separated. The aqueous layer was further extracted several times with DCM and the combined organic layer was washed with water and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography (DCM:MeOH = 9:1). L2 was obtained as a slightly yellow liquid. Yield: 34%. 1H NMR (200.13 MHz, DMSO-d6): delta = 8.58 (ddd, 1 H, 6-pyH), 8.09 (ddd, 1 H, 3-pyH), 7.87 (ddd, 1 H, 4-pyH), 7.32 (d, 1 H, 5-imH), 7.34 (ddd, 1 H, 5-pyH), 7.03 (d, 1 H, 4-imH), 4.75 (t, 2 H, NCH2CH2OCH3), 3.65 (t, 2 H, NCH2CH2OCH3), 3.19 (s,3 H, CH3) ppm. 13C NMR (50.33 MHz, DMSO-d6): delta = 151.0 (2-pyC), 149.3 (6-pyC), 143.9 (2-imC), 137.8 (4-pyC), 128.5 (4-imC),125.5 (5-imC), 123.3 (5-pyC), 122.9 (3-pyC), 72.1 (NCH2CH2OCH3),58.6 (CH3), 47.6 (NCH2CH2OCH3) ppm (Fig. S35, Supporting information). IR (diamond, ATR): ~v = 2892, 1588 (s), 1566, 1486 (s),1459 (vs), 1407, 1298, 1277, 1211, 1117 (vs), 1038, 1012, 992, 969, 917, 833, 791 (vs), 743 (vs), 708 (vs), 667, 624, 404 cm-1 (Fig. S22, Supporting information). APCI-MS (MeOH) m/z (rel. abundance,fragment) = 204.1132 (100%, [HL2]+) (Fig. S8, Supporting information). Elemental analysis (%)Anal. Calc. for C11H13N3O(203.24 g mol1): C, 65.01; H, 6.45; N, 20.67. Found: C, 64.69; H,6.46; N, 20.79%. UV-Vis (MeCN): lambdamax(epsilon) = 294 (15,850), 266(12,180) nm (M-1 cm-1) (Fig. S37, Supporting information).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine.

Reference:
Article; Huxel, Timo; Skaisgirski, Michael; Klingele, Julia; Polyhedron; vol. 93; (2015); p. 28 – 36;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 18653-75-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

Na2MoO4·2H2O (0.847g, 3.5mmol), 2-pyim (0.0065g, 0.040mmol), Mo powder (0.06g, 0.60mmol), ZnCl2 (0.136g, 1mmol), H3PO3 (0.02g, 0.25mmol), tetrabutylammonium hydroxide (TBAOH, 0.2mL, 0.3mmol) and distilled water (9.0mL) were stirred for 1h under the room temperature. An aqueous solution of 2molL-1 HCl was added into the mixture and the pH value was adjusted to 3.8. After that, the mixture continues to stir for an another 2h. Finally, the product was transferred to 25 Teflon-lined antoclave and was heated to 180C for 3days before cooled down to the room temperature. In the end, dark-red crystals 2 were collected and dried in air (yield: 62.45%). Elemental analysis: calculated: C, 14.11; H, 1.36; N, 6.17; found: C, 14.01; H, 1.28; N, 6.58.

According to the analysis of related databases, 18653-75-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Han, Ye-Min; Cheng, Wei-Wei; Cao, Jia-Peng; Yang, Mu-Xiu; Hong, Ya-Lin; Kang, Run-Kun; Xu, Yan; Inorganica Chimica Acta; vol. 498; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C8H7N3

The synthetic routes for the ligand L1 (white color) were reported in our previous work [15]. The ligand L2 (white color) was obtained by refluxing 2-(pyridin-2-yl) imidazole (obtained commercially from Aldrich and used as received) with ethylchloroacetate under basic conditions (Supporting information, Scheme 1) [23]. Yield ca. 90%. M.p.: 120-121C. Elemental Analysis (%) for L2 (C11H13O2N3), calcd: C, 60.24; H, 5.97; N, 19.17. Found: C, 60.37; H, 5.84; N, 19.06%. IR (KBr, cm-1): 3050, 2978, 2375, 2289, 1580, 1564, 1530, 1486, 1345, 1266, 1240, 1150, 1060, 1025, 980, 969, 790, 740, 725. 1H NMR delta, ppm: 1.30 (m, 3H), 4.12 (m, 2H), 4.7 (2, 2H), 6.88 (d, 1H), 7.15 (d, 1H), 7.4-8.5 (m, 4H). 13C NMR delta, ppm: 14.6, 48.4, 62.1, 120.5, 124.3, 128.5, 131.4, 137.2, 149.2, 155.6, 162.7.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine.

Reference:
Article; Luo, Yang-Hui; Wen, Gao-Ju; Gu, Lian-Shuai; Wang, Man-Ning; Sun, Bai-Wang; Polyhedron; vol. 121; (2017); p. 101 – 106;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 18653-75-3, Adding some certain compound to certain chemical reactions, such as: 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine,molecular formula is C8H7N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18653-75-3.

Chromium(III) chloride hexahydrate (0.266 g, 1 mmol) and pyim(0.145 g, 1 mmol) were disolved in 50 cm3 of water and refluxed for onehour at 80 C under continuous stirring. An aqueous solution of lithiumoxalate (2 mmol, 20 cm3) [generated in situ by reaction of stoichiometricamounts of oxalic acid and lithium hydroxide] was added andthe reflux was continued to 1.5 h. During this time, the initial greensolution turned deep violet. The resulting solution was filtered to discardany small solid particle and allowed to evaporate at room temperature.Reddish brown chunky crystals separated in several crops asfar as the volume was reduced during two weeks. They were collected by filtration and dried on filter paper. The recrystallization in methanol afforded X-ray quality crystals of 1 as reddish brown prisms. The yield is ca. 80%. Anal. Calc. for C13H11CrLiN3O9 (1): C, 37.89; H, 2.67; N,10.19. Found: C, 37.68; H, 2.58; N, 10.08%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fortea-Perez, Francisco Ramon; Pasan, Jorge; Pascual-Alvarez, Alejandro; Ruiz-Perez, Catalina; Julve, Miguel; Lloret, Francesc; Inorganica Chimica Acta; vol. 486; (2019); p. 150 – 157;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

18653-75-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine, molecular formula is C8H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 33 (1-33) A solution of iodine (6.99 g, 27.555 mmol) in DCM (29 mL) was added dropwise to a suspension of 2-(lH-imidazol-2-yl)pyridine (2g, 13.777 mmol) in NaOH (2M in water, 29 mL). The biphasic mixture was stirred vigorously at rt for 18 h. The aqueous layer was separated and neutralized with AcOH and then washed with sat. sol. Na2S203 was added until the solution remained colorless. The suspension was stirred for 10 min and the precipitate was filtered and dried in vacuo to yield 1-33 (4.45 g, 81%) as a solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALCAZAR-VACA, Manuel, Jesus; ALONSO-DE DIEGO, Sergio-Alvar; DE LUCAS OLIVARES, Ana, Isabel; (105 pag.)WO2016/87487; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem