Category: 186593-43-1

Related Products of 186593-43-1, Adding some certain compound to certain chemical reactions, such as: 186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 186593-43-1.

General procedure: 1.2.2.1. General method Bl To a stirred solution of Intermediate Gen-1 (1 to 1.2 eq.), and amine derivative (1 eq.) in DCM or DMF are added TBTU or HATU (1 to 1.2 eq.) followed by TEA or NMM (2 to 3 eq.) at room temperature under argon, the reaction mixture is stirred at room temperature until completion. Then the reaction is quenched with water, the layers are separated. The organic layer is dried over Na2SO i, filtered and evaporated to dryness. Alternatively, the reaction is concentrated in vacuo, the residue is partionned between EtOAc or a mixture of EtOAc/nBuOH and a saturated aqueous NH4C1 solution or water. The layers are separated, the organic layer is dried over Na2S04, filtered and evaporated to dryness. Then the residue is purified by chromatography on silica gel to afford the expected Intermediate.

According to the analysis of related databases, 186593-43-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALAPAGOS NV; SANIERE, Laurent Raymond Maurice; HUCK, Jacques; DYKES, Graeme James; SCHMITT, Benoit Antoine; BLANC, Javier; BUTLER, Anna Sara; BEAUMONT, Stephane Nicolas Alain; BONNATERRE, Florence Marie-Emilie; WO2015/24905; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 186593-43-1, 5-Amino-3-bromo-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 186593-43-1, blongs to pyridine-derivatives compound. Computed Properties of C6H7BrN2

4 – [(4-methyl-piperazin-1-yl) methyl] -3- (trifluoromethyl) benzoicacid (297 mg, 0.754 mmol), 2- (7- aza-benzotriazole ) -Nu, Nu, Nu ‘, Nu’-tetramethyluronium hexafluorophosphate (317 mg, 0.834 mmol) and N, N-diisopropylethylamine (0.17 mL, 1.043 mmol) was dissolved in N, N -dimethylformamide (5 mL) in. This mixture was added thereto and stirred atroom temperature for half an hour 5- bromo-6-methyl-3-aminopyridine (130 mg,0.695 mmol), stirred at room temperature continued overnight.After completionof the reaction by TLC, cooled to room temperature, water was added thereto,extracted with ethyl acetate, the organic phase was dried over anhydrous sodiumsulfate, filtered, and the solvent was evaporated to dryness, the residue waspurified by silica gel column chromatography to give N- (5- bromo – 6-methyl -pyridin-3-yl) -4- (4-methyl – piperazin-1-ylmethyl) -3-trifluoromethyl – benzamide(yellow solid, 80 mg)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,186593-43-1, its application will become more common.

Reference:
Patent; Shanghai Pharmaceuticals Holding Co.,Ltd .; WAN, HUIXIN; LI, CHUNLI; SHI, Chen; Liu, Haiyan; Li, Ping; XIA, Guangxin; HAN, Yanan; (52 pag.)CN103420977; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 186593-43-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine, molecular formula is C6H7BrN2, molecular weight is 187.0372, as common compound, the synthetic route is as follows.

Step 1: EDC (1.3 equiv.) was added to a solution of 5-bromo-6-methylpyridin-3-amine (1.05 equiv), 2-(2-cyanopropan-2-yl)isonicotinic acid (1.0 equiv), HOAt (1.3 equiv) in DMF (0.17 M). The mixture was stirred at ambient temperature 3 hrs. The reaction mixture was diluted with water and extracted with ethyl acetate. The combined extracts were washed sequentially with 1M aqueous sodium hydroxide and brine, dried over sodium sulfate, filtered, and concentrated. The crude was purified by ISCO(50% EtOAc/Heptane). Combined fractions still contained 17% 5-bromo-6-methylpyridin-3-amine. Add 2-(2-cyanopropan-2-yl)isonicotinic acid (0.3 equiv), EDC (0.3 equiv), HOAt (0.3 equiv) in DMF (0.17 M). After stirred at rt overnight, the reaction mixture was diluted with water and extracted with ethyl acetate. The combined extracts were washed sequentially with 1M aqueous sodium hydroxide and brine, dried over sodium sulfate, filtered, and concentrated to yield N-(5-bromo-6-methylpyridin-3-yl)-2-(2-cyanopropan-2-yl)isonicotinamide in 71% over three steps. LCMS (m/z) (M+H)=359.0, Rt=0.73 min.

Statistics shows that 186593-43-1 is playing an increasingly important role. we look forward to future research findings about 5-Amino-3-bromo-2-methylpyridine.

Reference:
Patent; NOVARTIS AG; Barsanti, Paul A.; Burger, Matthew; Lou, Yan; Nishiguchi, Gisele; Polyakov, Valery; Ramurthy, Savithri; Rico, Alice; Setti, Lina; Smith, Aaron; Taft, Benjamin; Tanner, Huw; DiPesa, Alan; Yusuff, Naeem; US2014/275003; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H7BrN2

[0196] A stirred mixture of 5-bromo-6-methylpyridin-3-amine (0.100 g, 0.535 mmol), 4,4,5,5,4?,4?,5?,5?-octamethyl-[2,2?jbi[[1 ,3,2] dioxaborolanyll (0.136 g, 0.535 mmol), [1,1 bis(diphenylphosphino)ferrocenej dichloropalladium(II) complexed with dichloromethane (1:1) (42 mg, 0.051 mmol) and potassium acetate (0.150 g, 1.53 mmol) in 1,4-dioxane (5.0 mL) was heated at 110C. After 2 hours, the reaction was quenched with saturated aqueous NH4C1, and extracted with DCM (3 x30 mL). The organic layers were combined, dried over Na2SO4, and concentrated. The crude product was used directly in the next step without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 186593-43-1, 5-Amino-3-bromo-2-methylpyridine.

Reference:
Patent; INCYTE CORPORATION; LU, Liang; WU, Liangxing; SHEN, Bo; YAO, Wenqing; (114 pag.)WO2016/134294; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 186593-43-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine, molecular formula is C6H7BrN2, molecular weight is 187.0372, as common compound, the synthetic route is as follows.

Step 2: To a 0.18 M solution of 5?-amino-1,2?-dimethyl-5-morpholino-[3,3?-bipyridin]-6(1H)-one (1.00 equiv.) in DME and 5-bromo-6-methylpyridin-3-amine (1.00 equiv.) was added PdCl2(dppf).CH2Cl2 adduct (0.10 equiv.) and 2M aqueous sodium carbonate (3.00 equiv.). The reaction mixture was irradiated at 125 C. for 20 min. LC-MS showed primarily conversion to P. The cooled reaction mixture was diluted with 2:1 DCM:MeOH and filtered. The filtrate was concentrated and purified by flash chromatography over silica gel (ethyl acetate with a 0-15% methanol gradient) to give 5?-amino-1,2?-dimethyl-5-morpholino-[3,3?-bipyridin]-6(1H)-one as a brown solid. LCMS (m/z) (M+H)=301.0, Rt=0.33 min.

The chemical industry reduces the impact on the environment during synthesis 186593-43-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVARTIS AG; Barsanti, Paul A.; Burger, Matthew; Lou, Yan; Nishiguchi, Gisele; Polyakov, Valery; Ramurthy, Savithri; Rico, Alice; Setti, Lina; Smith, Aaron; Taft, Benjamin; Tanner, Huw; DiPesa, Alan; Yusuff, Naeem; US2014/275003; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem