Category: 188425-85-6

Reference of 188425-85-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 188425-85-6, name is 2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide. A new synthetic method of this compound is introduced below.

Add in a 100ml round bottom flask11-bromodecanoic acid 1 g (3.77 mmol),EDCI (0.72 g, 3.77 mmol) and HoBT (0.5 g, 3.77 mmol),Add 40 ml of dichloromethane to react for 15 min.Then, Boscalid {2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide} 1.24 g (3.6 mmol) was added. After 4 h of reaction, 1.5 g of 2-chloro-N-(4-chlorobiphenyl-2-yl)-N-(11-bromoundecyl)nicotinamide was obtained in a yield of 93%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,188425-85-6, its application will become more common.

Reference:
Patent; China Agricultural University; Tan Zhaohai; Wang Jiayao; Liu Xuelian; Tang Dachao; Xiao Yumei; Li Jiaqi; (46 pag.)CN109053801; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 188425-85-6, name is 2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide, molecular formula is C18H12Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide

For a 1 :1 co-crystal of boscalid and 4-hydroxy benzoic acid, 200,0 mg of boscalid, 80,4 mg of 4-hydroxi benzoic acid and 150 muIota of ethanol was grinded in a ball mill (Retsch Modell MM301 ) for 10 minutesby using 20 Hz. The crystalline product gave the PXRD in Figure 4 (table 6).

With the rapid development of chemical substances, we look forward to future research findings about 188425-85-6.

Reference:
Patent; BASF SE; SAXELL, Heidi, Emilia; ISRAELS, Rafel; SCHAeFER, Ansgar; BRATZ, Matthias; HOeFFKEN, Hans, Wolfgang; BRODE, Ingo; NAUHA, Elisa; NISSINEN, Maija; WO2011/54741; (2011); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 188425-85-6, name is 2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide, molecular formula is C18H12Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide

For a 1 :1 co-crystal of boscalid and 4-hydroxy benzoic acid, 200,0 mg of boscalid, 80,4 mg of 4-hydroxi benzoic acid and 150 muIota of ethanol was grinded in a ball mill (Retsch Modell MM301 ) for 10 minutesby using 20 Hz. The crystalline product gave the PXRD in Figure 4 (table 6).

With the rapid development of chemical substances, we look forward to future research findings about 188425-85-6.

Reference:
Patent; BASF SE; SAXELL, Heidi, Emilia; ISRAELS, Rafel; SCHAeFER, Ansgar; BRATZ, Matthias; HOeFFKEN, Hans, Wolfgang; BRODE, Ingo; NAUHA, Elisa; NISSINEN, Maija; WO2011/54741; (2011); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 188425-85-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 188425-85-6, name is 2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide, molecular formula is C18H12Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 2-chloro-N-(4′-chloro-5-hydroxybiphenyl-2-yl)nicotinamide, which is the main metabolite of boscalid, was prepared following the synthetic scheme depicted in Fig. 1. Briefly, phenyliodine(III) bis(trifluoroacetate) (PIFA, 451 mg, 1.049 mmol, 1.2 equiv) was added to a solution of boscalid (300 mg, 0.875 mmol) and trifluoroacetic acid (673 muL, 7.4 mmol, 10 equiv) in CHCl3 (11.5 mL). After stirring for 3 h at room temperature, the reaction mixture was cooled in an ice bath and then quenched by the addition of 5% NaHCO3 (30 mL). The aqueous layer was extracted with EtOAc and the combined organic layers were washed with brine and dried over anhydrous MgSO4. The brownish residue left after evaporation of the solvent was purified by column chromatography, using CHCl3/CH3OH 99:1 as eluent, to afford metabolite M510F01. IR vmax/cm-1 (NaCl) 3377, 3230, 3028, 1652, 1580, 1394, 1088, 1012, 749; 1H NMR (300 MHz, CDCl3) delta 8.42 (1H, dd, J = 4.8, 1.8 Hz, H-6 Py), 8.03 (1H, dd, J = 7.8, 1.8 Hz, H-4 Py), 7.99 (1H, br s, NH), 7.82 (1H, d, J = 8.7 Hz, H-3 PhPh), 7.38-7.23 (5H, m, H-2’/H-6′, H-3’/H-5′ and H-5 Py), 6.81 (1H, dd, J = 8.7, 3 Hz, H-4 PhPh), 6.72 (1H, d, J = 3 Hz, H-6 PhPh); 13C NMR (75 MHz, CDCl3) delta 163.44 (CON), 154.17 (C-5 PhPh), 151.24 (C-6 Py), 146.85 (C-2Py), 139.82 (C-4 Py), 136.22 (C-3 Py), 135.73 (C-10), 134.27 (C-4’PhPh), 130.89 (C-2 PhPh), 130.41 (C-3’/C-5′ PhPh), 129.02 (C-2’/C-6′ PhPh), 126.13 (C-1 PhPh), 125.69 (C-5 Py), 122.88 (C-2 PhPh), 117.16 (C-4 PhPh), 115.71 (C-6 PhPh); HRMS (TOF MS), calculated for C18H1135Cl2N2O2 [M-H]+ 357.0198, found 357.0219.

According to the analysis of related databases, 188425-85-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Esteve-Turrillas, Francesc A.; Mercader, Josep V.; Agullo, Consuelo; Abad-Somovilla, Antonio; Abad-Fuentes, Antonio; Food Chemistry; vol. 267; (2018); p. 2 – 9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem