Category: 189005-44-5

Reference of 189005-44-5 ,Some common heterocyclic compound, 189005-44-5, molecular formula is C17H16N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

One proceeds as described in Example 7 except that concentrated sulfuric acid is replaced by 5 ml of concentrated hydrochloric acid and the reaction mixture is refluxed for 5 hours. Thus 21.5 g of methyl-[6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetate are obtained. The product is identical in all respects with the compound prepared according to Example 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 189005-44-5, 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EGIS GYOGYSZERGYAR RT.; EP1259509; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 189005-44-5, 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, blongs to pyridine-derivatives compound. Recommanded Product: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid

To a suspension of 28 g (0.10 mole) of [6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetic acid and 200 ml of methanol 6.9 ml (12.8 g, 0.13 mole) of concentrated sulfuric acid are added dropwise. The reaction mixture is heated to boiling for 3 hours, whereupon it is cooled first to room temperature and then to 5-10C under external cooling and stirred at this temperature for an hour. The precipitated crystalline product (the sulfuric acid salt of the title compound) is filtered, washed with methanol and dried. The product thus obtained is suspended in 500 ml of water and the pH is adjusted to 8 by adding a 10 % sodium carbonate solution under intensive stirring. The precipitated product is filtered, washed twice with 70 ml of water each. Thus 27.4 g of methyl-[6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetate are obtained in the form of white crystals. Yield 93.3 %, mp.: 133 -136C. IR (KBr) 2950, 1729, 1538, 1503, 1437, 1408, 1391, 1332, 1308, 1273, 1229, 1177, 1133, 1042, 994, 890, 823, 787, 753, 737, 706, 587, 553, 514, 417. 1H-NMR (CDCl3):delta, ppm 7.84 (1H, s, H-5); 7.69 (2H, d, J 8.0 Hz, H-2′,6′); 7.56 (1 H, d, J 9.2 Hz, H-8); 7.28 (2H, d, J 8.0 Hz, H-3′,5′); 7.06 (1H, dd, J 1.5 and 9.2 Hz, H-7); 4.02 (2H, s, CH2); 3.76 (3H, s, CH3); 2.40 (3H, s, CH3-4′); 2.35 (3H, s, CH3-6). 13C-NMR (CDCl3): delta, ppm 169.9 (C=O); 144.3 (C-8a); 143.9 (C-2); 137.5 (C-4′); 131.2 (C-1′); 129.2 (C-3′,5′); 128.2 (C-2′,6′); 127.5(C-7); 122.0 (C-5); 121.1 (C-6); 116.7 (C-8); 112.1 (C-3); 52.4 (COOCH 3); 30.5 (CH2); 21.2 (CH3-4′); 18.3 (CH3-6).

The synthetic route of 189005-44-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EGIS GYOGYSZERGYAR RT.; EP1259509; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.189005-44-5, name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, molecular formula is C17H16N2O2, molecular weight is 280.3211, as common compound, the synthetic route is as follows.COA of Formula: C17H16N2O2

One proceeds as described in Example 2 except that methanolic hydrogen chloride is replaced by 5.0 g of p -toluene-sulfonic acid catalyst and the reaction mixture is heated to boiling for 6 hours. The crystalline product is recrystallized from acetonitrile. Thus 22.2 g of methyl-[6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetate are obtained, yield 75.6 %. The product is identical in all respects with the compound prepared according to Example 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,189005-44-5, 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, and friends who are interested can also refer to it.

Reference:
Patent; EGIS GYOGYSZERGYAR RT.; EP1259509; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 189005-44-5, Name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, molecular formula is C17H16N2O2. In an article, author is Istadi, I.,once mentioned of 189005-44-5, SDS of cas: 189005-44-5.

Biofuels Production from Catalytic Cracking of Palm Oil Using Modified HY Zeolite Catalysts over A Continuous Fixed Bed Catalytic Reactor

The increase in energy demand led to the challenging of alternative fuel development. Biofuels from palm oil through catalytic cracking appear as a promising alternative fuel. In this study, biofuel was produced from palm oil through catalytic cracking using the modified HY zeolite catalysts. The Ni and Co metals were impregnated on the HY catalyst through the wet-impregnation method. The catalysts were characterized using X-ray fluorescence, X-ray diffraction, Brunauer-Emmett-Teller (BET), Pyridine-probed Fourier-transform infrared (FTIR) spectroscopy, and Scanning Electron Microscopy (SEM) methods. The biofuels product obtained was analyzed using a gas chromatography-mass spectrometry (GC-MS) method to determine its composition. The metal impregnation on the HY catalyst could modify the acid site composition (Lewis and Bronsted acid sites), which had significant roles in the palm oil cracking to biofuels. Ni impregnation on HY zeolite led to the high cracking activity, while the Co impregnation led to the high deoxygenation activity. Interestingly, the co-impregnation of Ni and Co on HY catalyst could increase the catalyst activity in cracking and deoxygenation reactions. The yield of biofuels could be increased from 37.32% to 40.00% by using the modified HY catalyst. Furthermore, the selectivity of gasoline could be achieved up to 11.79%. The Ni and Co metals impregnation on HY zeolite has a promising result on both the cracking and deoxygenation process of palm oil to biofuels due to the role of each metal. This finding is valuable for further catalyst development, especially on bifunctional catalyst development for palm oil conversion to biofuels.

Interested yet? Keep reading other articles of 189005-44-5, you can contact me at any time and look forward to more communication. SDS of cas: 189005-44-5.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 189005-44-5, Name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid. In a document, author is Ma, Jing-xin, introducing its new discovery. Computed Properties of C17H16N2O2.

Construction of Transition Metal Coordination Polymers with Free Carboxyl Groups and Turn-On Fluorescent Detection for alpha,beta-Diamine

In this work, three new coordination polymers with a free carboxyl group, [Zn-4(HIDCPy)4(DMSO)(DMF)3]n (1), [Cu(HIDCPyO)(DMSO)]n (2), and {[Cd4(HIDCPy)6].4DMF.4C2H8N.H2O}n (3) (H2IDCPy = 2-(pyridine-2-yl)-1H-imidazole-4,5-dicarboxylic acid), had been successfully constructed by fine conditions control. Owing to the good fluorescence performance of 1, we explored the complex as a fluorescence sensor for alkaline matters, such as ammonia and amines. The test of selectivity showed that only a,B–diamine, ethylenediamine (En) and 1,2–propylenediamine (1,2-PDA), could greatly sensitize the fluorescence of 1. The fluorescence titration showed the detection limits of 1 were 3.93 ppm for En and 3.21 ppm for 1,2-PDA, respectively. Moreover, the competing and circulating experiments indicated that 1 had satisfactory anti-interference and recyclability toward En and 1,2-PDA sensing. All of these results implied 1 should be a potential turn-on fluorescent probe for detecting alpha,beta–diamine, and the sensing mechanism had also been in-depth elaborated. At the same time, as the control experiments, the fluorescence sensing of 3 toward ammonia and amines was carried out. The results showed that alpha,beta–diamine and other amines could also sensitize the fluorescent emission of 3, but there was a significant gap with 1 in the selectivity and sensitivity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 189005-44-5 help many people in the next few years. Computed Properties of C17H16N2O2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 189005-44-5, Name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, molecular formula is C17H16N2O2. In an article, author is Tong, Shuo,once mentioned of 189005-44-5, SDS of cas: 189005-44-5.

Domino Reactions of Tertiary Enamides in Organic Synthesis

Studies in recent decade have shown that tertiary enamides, once thought of as unreactive and marginally useful enamine variants, are shelf-stable yet versatile nucleophilic intermediates in organic synthesis. Many compounds, especially N-heterocycles, have been synthesized by monofunctionalization reactions of tertiary enamides. By taking advantage of intramolecular and intermolecular interception of the putative acyliminium intermediates formed by the initial nucleophilic reactions of tertiary enamides, we have established several novel difunctionalization reaction methods for constructing diverse complex fused heterocyclic products. In this Account, we summarize our endeavors to develop difunctionalization reactions of tertiary enamides in a domino fashion.

Interested yet? Keep reading other articles of 189005-44-5, you can contact me at any time and look forward to more communication. SDS of cas: 189005-44-5.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 189005-44-5, Name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Zilla, Mahesh K., HPLC of Formula: C17H16N2O2.

An efficient synthesis of 4-phenoxy-quinazoline, 2-phenoxy-quinoxaline, and 2-phenoxy-pyridine derivatives using aryne chemistry

Herein we report the mild and efficient synthesis of 4-phenoxyquinazoline, 2-phenoxyquinoxaline, and 2-phenoxypyridine derivatives from the starting materials viz. quinazolin-4(3H)-one, quinoxalin-2(1H)-one, and pyridin-2(1H)-one and aryne generated in situ from 2-(trimethylsilyl)phenyl trifluoromethanesulfonate and cesium fluoride. This synthetic methodology gives a new environmentally benign way for the preparation of several unnatural series of 4-phenoxyquinazoline, 2-phenoxyquinoxaline and 2-phenoxypyridine compounds with high yields and broad substrate scope.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 189005-44-5, in my other articles. HPLC of Formula: C17H16N2O2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 189005-44-5, Name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Wang, Si-Qing, Recommanded Product: 189005-44-5.

Copper(I)-Catalyzed Asymmetric Vinylogous Aldol-Type Reaction of Allylazaarenes

A vinylogous aldol-type reaction of allylazaarenes and aldehydes is disclosed that affords a series of chiral gamma-hydroxyl-alpha,beta-unsaturated azaarenes in moderate to excellent yields with high to excellent regio- and enantioselectivities. With (R,R-P)-TANIAPHOS and (R,R)-QUINOXP* as the ligand, the carbon-carbon double bond in the products is generated in (E)-form. With (R)-DTBM-SEGPHOS as the ligand, (Z)-form carbon-carbon double bond is formed in the major product. In this vinylogous reaction, aromatic, alpha,beta-unsaturated, and aliphatic aldehydes are competent substrates. Moreover, a variety of azaarenes, such as pyrimidine, pyridine, pyrazine, quinoline, quinoxaline, quinazoline, and benzo[d]imidazole are well-tolerated. At last, the chiral vinylogous product is demonstrated as a suitable Michael acceptor towards CuI-catalyzed nucleophilic addition with organomagnesium reagents.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 189005-44-5, in my other articles. Recommanded Product: 189005-44-5.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 189005-44-5, Name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid. In a document, author is Roy, Sebastien A., introducing its new discovery. Name: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid.

Palladium catalyzed synthesis of indolizines via the carbonylative coupling of bromopyridines, imines and alkynes

We report herein the development of a palladium-catalyzed, multicomponent synthesis of indolizines. The reaction proceeds via the carbonylative formation of a high energy, mesoionic pyridine-based 1,3-dipole, which can undergo spontaneous cycloaddition with alkynes. Overall, this provides a route to prepare indolizines in a modular fashion from combinations of commercially available or easily generated reagents: 2-bromopyridines, imines and alkynes.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 189005-44-5 help many people in the next few years. Name: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 189005-44-5, Name is 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, SMILES is CC1=CC=C(C=C1)C1=C(CC(O)=O)N2C=C(C)C=CC2=N1, belongs to pyridine-derivatives compound. In a document, author is Wang, Zhuozhi, introduce the new discover, Category: pyridine-derivatives.

Effect of reaction conditions on the evolution of surface functional groups in O-2/H2O combustion process of demineralized coal char

O-2/H2O combustion is now regarded as a novel and promising technology of coal utilization for next-generation oxy-fuel combustion. The combustion reaction mainly occurs in the mixture of O-2 and H2O instead of recycled flue gas (mainly CO2). The purpose of this research is to clarify the evolution characteristics of O/N-containing complexes (C(O)/C(N)) during O-2/H2O combustion. Fourier transform infrared spectroscopy (FT-IR), temperature programmed desorption (TPD) and X-ray photoelectron spectroscopy (XPS) were employed in this study. The addition of H2O in the atmosphere promoted the generation of NO and HCN in char combustion. There was a good linear relationship between the C(O) amount and char reactivity, as well as the NO conversion ratio, during the O-2/H2O combustion process. Moreover, trace amounts of the precursors of CO2 with low thermal stability remained on the particle surface in the O-2/H2O combustion. The enhancement of the reaction temperature revealed positive effects on inhibiting NO emissions in the O-2/H2O combustion. The relative amount of pyrrole (N-5), which was the precursor of HCN, increased apparently at the expense of pyridine (N-6) and quaternary nitrogen (N-Q) in the early reaction stage. VVhen the char conversion degree exceeded 50%, N-Q and N-6 became the dominant forms of C(N).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 189005-44-5 is helpful to your research. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem