Related Products of 19346-47-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19346-47-5, name is 2-Fluoro-4-methyl-5-nitropyridine. A new synthetic method of this compound is introduced below.
Intermediate 85 tert-Butyl 4-(4-methyl-5-nitropyridin-2-yl)piperazine-1-carboxylate [0306] 2-Fluoro-4-methyl-5-nitropyridine (0.8 g, 5.12 mmol), tert-butyl piperazine-1-carboxylate (1.05 g, 5.64 mmol) and potassium carbonate (0.85 g, 6.15 mmol) were taken up in acetonitrile (15 mL) and heated at 60 C. for 1.5 h. After this time, the reaction was quenched with water (20 mL) and extracted with EtOAc (2×30 mL). The organic layers were combined and dried over sodium sulphate, then concentrated in vacuo. The crude material was purified by column chromatography (silica gel: 100-200 mesh, 1:1 EtOAc/heptane) to give the title compound (1.57 g, 97%). LCMS (ES+) 323.1 (M+H)+, RT 1.71 minutes (method 4).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,19346-47-5, 2-Fluoro-4-methyl-5-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Brookings, Daniel Christopher; Ford, Daniel James; Franklin, Richard Jeremy; Ghawalkar, Anant Ramrao; Kulisa, Claire Louise; Neuss, Judi Charlotte; Reuberson, James Thomas; US2014/315885; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem