Category: 19437-26-4

Application of 19437-26-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 19437-26-4 as follows.

General procedure: Two drops of glacial acetic acid as a catalyst were added to themixtures of thiosemicarbazides (0.5 mmol) and di(2-pyridyl) ketone,2-pyridinecarboxaldehyde, 2-quinolinecarboxaldehyde, 8-hydroxy-2-quinolinecarboxaldehyde or 2-quinoxalinecarbaldehyde (0.5 mmol) in ethanol (5 ml). The glasstubes were sealed and placed into a microwave reactor at 83 C for20 min (the reactor power did not exceed 50W). The final productswere crystallized from dry methanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19437-26-4, its application will become more common.

Reference:
Article; Mrozek-Wilczkiewicz, Anna; Malarz, Katarzyna; Rejmund, Marta; Polanski, Jaroslaw; Musiol, Robert; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 180 – 194;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19437-26-4, name is Di(pyridin-2-yl)methanone, molecular formula is C11H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

A mixture of p-toulenesulphonyl hydrazine (200 mg,1.29 mmol) and dipyridyl ketone (238 mg, 1.29 mmol) alongwith two drops of glacial acetic acid was refluxed inmethanol for 6 h (Scheme 1). The solvent was removed usingrotavapor and the product, yellow oily mixture was passedthrough silica gel column using hexane and methanol (1:1)as solvents. The compound was obtained as yellow solid.M.p.: 160C. Yield: (75%). FTIR (KBr pellet, cm-1): 3079nu(C-H), 1631 nu(C=N), 1601 nu(C=C). 1H NMR (DMSO-d6, 400MHz, delta, ppm): 9.24 (d, 1H, JHH = 7.2 Hz), 8.75 (d, 1H,JHH = 4.4 Hz), 8.53 (d, 1H, JHH = 8.8 Hz), 8.37 (d, 1H,JHH = 7.6 Hz), 8.20-8.13 (m, 2H), 7.67 (t, 1H, JHH = 7.6Hz), 7.36 (t, 1H, JHH = 7.6 Hz). UV/Vis (MeOH) lambdamax, nm(epsilon, M-1 cm-1) = 222 (2.12 ¡Á 105), 264 (1.0 ¡Á 105), 306(1.21 ¡Á 105). HRMS (ESI) m/z: calcd.: 196.0749, found: 197.0851 [M+H]+. Anal. Calcd. (%) for C11H8N4C, 67.34;H, 4.11; N, 28.55. Found (%): C, 67.64; H, 3.91; N, 28.75.

With the rapid development of chemical substances, we look forward to future research findings about 19437-26-4.

Reference:
Article; Palepu, Narasinga Rao; Kollipara, Mohan Rao; Journal of Chemical Sciences; vol. 129; 2; (2017); p. 177 – 184;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19437-26-4 ,Some common heterocyclic compound, 19437-26-4, molecular formula is C11H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 300 mL three-necked flask was added 30 mL of a dehydrated THF solution of 4.12 g of Compound I and the mixture was stirred at -78 C.To this was dropped 6.3 mL of 1.58 M n-BuLi hexane solution, and the mixture was stirred for 2.5 hours. To this was added 45 mL of a dehydrated THF solution of 1.64 g of di-2-pyridinyl-methanone, and the mixture was stirred for 2 hours and then stirred at room temperature for 3 hours. After the reaction, 1N hydrochloric acid aqueous solution was added to this mixture and stirred for 1 hour. After washing with water and concentrating the obtained organic phase, a viscous solid was obtained. This viscous solid, 30 mL of glacial acetic acid and 1.4 mL of hydrochloric acid were placed in a 300 mL flask, and the mixture was heated and stirred at 130 C. for 2 hours under a nitrogen atmosphere to react. After the reaction, the reaction mixture was added dropwise to ice-cooled 150 mL of water. After precipitating white crystals, the produced solid was filtered off, washed with methanol and then dried. Finally, 4.15g (83% yield) of a white powder of Compound 111 was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19437-26-4, its application will become more common.

Reference:
Patent; SAMSUNG DISPLAY COMPANY LIMITED; ITOI, HIROAKI; MIYAKE, HIDEO; KAWAMURA, HISAYUKI; (119 pag.)JP2017/203026; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem