Category: 19524-06-2

Application of 19524-06-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

CuI (95 mg, 0.50 mmol), (Ph3P)2PdCl2 3(174 mg, 0.25 mmol), Na ascorbate (98 mg, 0.50 mmol) and 4-bromopyridinehydrochloride 22 (970 mg, 5.0 mmol) wereplaced in a flask, which was degassed and filled with Ar. Pri2NH (10 mL) andTHF (10 mL) were added. The mixture was stirred at 40°C for 30 min. Me3SiC?CH (532 mg, 5.0 mmol) was added and themixture was stirred at 40°C for 10 h. Evaporation and chromatography (petroleumether / EtOAc 5:1 ? 3:1) gave 20l (767mg, 89percent) as a pale buff oil (lit.7 yellow liquid); 1H NMR(CDCl3) d 0.27 (9 H, s, SiMe3), 7.29 (2 H, d, J = 4.4 Hz, 3,5-H2) 8.55 (2 H, d, J = 4.4 Hz, 2,6-H2); 13C NMR (CDCl3)d -0.002 (SiMe3),100.24 (ethyne 2-C), 102.31 (ethyne 1-C), 126.16 (3,5-C2), 131.52(4-C), 150.03 (2,6-C2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19524-06-2, 4-Bromopyridine hydrochloride.

Reference:
Article; Kumpan, Katerina; Nathubhai, Amit; Zhang, Chenlu; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Haikarainen, Teemu; Lehtioe, Lari; Threadgill, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3013 – 3032;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H5BrClN

In a Schlenk flask under argon 4-bromo-5-methylthiophene-2-ylboronicacid (3.2 g, 14.14 mmol) was dissolved in THF (25 mL) and degassed.4-bromopyridine hydrochlorid (4.43 g, 22.68 mmol), Pd(dppf)Cl2(740 mg, 0.91 mmol) and aq Na2CO3 solution (20percent, 25 mL) wereadded and the mixture was stirred under reflux overnight at 80 °C.The reaction mixture was extracted three times with DCM, the combined organic phases werewashed with water and brine, dried over MgSO4, filtered and the solvents was removed underreduced pressure. Purification by flash column chromatography (pure cyclohexane + 1percentNEt3) afforded a brownish solid with a yield of 51percent.

With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.

Reference:
Article; Sarter, Christopher; Heimes, Michael; Jaeschke, Andres; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1103 – 1110;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19524-06-2, name is 4-Bromopyridine hydrochloride, molecular formula is C5H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 19524-06-2

General procedure: In a 10-mL glass tube were placed halide (1.0mmol); 2-formylphenyl or 2-pyridyl MIDA boronate (1.5mmol) or allyl MIDA boronate; K2CO3 (3.0 mmol); Pd EnCat30(6mol%); and ethanol/H2O (4:1v/v) or water, and a magnetic stir bar. The vessel was sealed with a septum and placed into the microwave cavity. The temperature was ramped from rt to 120C or 135C. Once the reaction temperature was reached, the reaction mixture was held at this temperature for 10-18 min. After the mixture was allowed to cool to room temperature, the reaction vessel was opened and the contents were poured into a separating funnel. Water and ethylacetate (3×10mL) were added. The combined organics were dried over Na2SO4, filtered, and concentrated in vacuo. The organic residue was adsorbed onto silicagel, and then purified by column flash chromatography (hexane = ethyl acetate as eluent) to afford the desired product 1a-x. The biaryls, bipyridines, or allylphenols prepared are known compounds. [23-45] The products were confirmed by comparing the 1H NMR and mass spectral data with authentic samples reported in the literature.

With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.

Reference:
Article; Da Silva, Joaquim F. M.; Yepes Perez, Andres F.; De Almeida, Natalia P.; Synthetic Communications; vol. 45; 17; (2015); p. 1995 – 2004;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 19524-06-2, 4-Bromopyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H5BrClN, blongs to pyridine-derivatives compound. COA of Formula: C5H5BrClN

A solution of 4-bromo-pyridine hydrochloride (25 g, 128 mmol) in dichloromethane (250 mL) was treated with potassium carbonate (21.25 g, 153 mmol) and the mixture was stirred for 2 hours, followed by addition of m-chloroperbezoic acid (44 g, 256 mmol). The mixture was stirred at room temperature for 16 hours, solid precipitated out, filtered and washed with ethyl acetate (2*200 mL). The filtrate was concentrated to give solid material which was washed with ether and hexane (3*30 mL, 1:1). The solid (20 g, 90percent) obtained was used as such for next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19524-06-2, 4-Bromopyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Daiichi Sankyo Company, Limited; Verma, Ashwani Kumar; Nagaswamy, Kumaragurubaran; Sharma, Lalima; Ghosh, Soma; Kale, Balkrishna Ramchandra; Mondal, Aniruddha; Srivastava, Punit Kumar; Dastidar, Sunanda Ghosh; Momin, Rijwan Jaffer; Wagh, Pradip Balu; Pansare, Sonali Nanasaheb; Markad, Pramod Raosaheb; Khairnar, Yogesh Balasaheb; Miyauchi, Rie; Murata, Takeshi; Ishizaki, Masayuki; Nagamochi, Masatoshi; Iimura, Shin; US2014/155398; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 19524-06-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

4-Bromopyridine hydrochloride (11.7 g) and 4-carboxyphenylboronic acid (10.0 g) were dissolved in a solvent mixture of toluene (250 mL) and water (250 mL), and to the solution were sequentially added tetrakis(triphenylphosphine)palladium(0) (5.0 g) and anhydrous sodium carbonate (25.4 g), followed by heating under reflux at 120°C for 19 hours. After the resultant mixture was cooled to room temperature, ethyl acetate was added thereto, and the thus-obtained mixture was extracted with water. Concentrated HCl was added to the aqueous layer, to thereby make the mixture acidic. The aqueous layer was washed with ethyl acetate, and was concentrated. The resultant solid was collected by filtration, to thereby give the title compound (8.37 g).1H-NMR(DMSO-d6) delta:8.11(2H, d, J=8.8Hz), 8.14(2H, dJ=8.8Hz), 8.35(2H, d, J=6.6Hz), 8.97(2H, d, J=6.6Hz). MS (FAB) m/z:200 (M+H)+.

According to the analysis of related databases, 19524-06-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1577301; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 19524-06-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19524-06-2, name is 4-Bromopyridine hydrochloride. A new synthetic method of this compound is introduced below.

Zinc bromide (502 g, 2.23 mole) was added in approximately 100 g portions to 2.0 L of tetrahydrofuran cooled to between 0 and 10°C. To this cooled solution was added 4- bromopyridine hydrochloride (200 g, 1.02 mol), triphenylphosphine (54 g, 0.206 mol), and palladium (II) chloride (9.00 g, 0.0508 mol). Triethylamine (813 g, 8.03 mol) was then added at a rate to maintain the reaction temperature at less than 10°C, and finally trimethylsilylacetylene (202 g, 2.05 mol) was added. The mixture was heated to 60°C for 4.5 hours. The reaction was cooled to -5°C and combined with 2.0 L of hexanes and treated with 2 L of 7.4 M NH4OH. Some solids were formed and were removed as much as possible with the aqueous phase. The organic phase was again washed with 2.0 L of 7.4 M NH4OH, followed by 2 washes with 500 mL of water, neutralized with 1.7 L of 3 M hydrochloric acid, dried with sodium sulfate, and concentrate to a thick slurry. The slurry was combined with 1.0 L of hexanes to give a precipitate. The precipitate was removed by filtration and the filtrate was concentrated to 209 g of dark oil. The product was purified by distillation (0.2 torr, 68°C) to give 172 g (96percent) of Compound (VI) as colorless oil. Analytical data: NMR (500 MHz, DMDO-de) delta 8.57 (2 H), 7.40 (2 H), 0.23 (9 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19524-06-2, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; KOPACH, Michael, E.; WILSON, Thomas, Michael; KOBIERSKI, Michael, Edward; (35 pag.)WO2017/31215; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 19524-06-2, Adding some certain compound to certain chemical reactions, such as: 19524-06-2, name is 4-Bromopyridine hydrochloride,molecular formula is C5H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19524-06-2.

4-Bromopyridine hydrochloride (3.0 g, 15.4 mmol) was dissolved in water (15 mL). After addition of N-benzylpiperazine (14.8 mL, 85.0 mmol) and 500 mg copper sulfate, the reaction mixture was heated overnight to 140 C. The resulting product was extracted with ether (5?75 mL), dried over sodium sulfate and concentrated. Final purification by column chromatography (dichloromethane/methanol/NH4OH=10/1/0.1) yielded the desired product (2.16 g, 55percent). 1H NMR (300 MHz, d-CDCl3) 2.68 (dd, 4H), 3.45 (dd, 4H), 6.76 (d, 2H), 7.40 (m, 5H), 8.38 (d, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19524-06-2, 4-Bromopyridine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Name: 4-Bromopyridine hydrochloride, 19524-06-2, Name is 4-Bromopyridine hydrochloride, SMILES is BrC1=CC=NC=C1.[H]Cl, in an article , author is Yin, Defeng, once mentioned of 19524-06-2.

Oxidative esterification of renewable furfural on cobalt dispersed on ordered porous nitrogen-doped carbon

A series of highly dispersed cobalt-based catalysts on N-doped ordered porous carbon (Co-NOPC) were synthesized using the sacrificial-template method. MCM-41, ZSM-5 and SBA-15 were employed as hard templates with 2,2 ‘-bipyridine as the ligand. The physical and chemical properties of the Co-NOPC catalyst were characterized by Raman, XRD, SEM, TEM, EDX, ICP, BET, XPS. Co-NOPC had been proven to be a highly efficient catalyst for oxidative esterification of furfural (FUR) to methyl 2-furoate without alkaline additives. Catalytic performance was correlated to the dispersed cobalt, porous structure and specific surface area. The relationship between oxygen activation and the strong interaction of cobalt and pyridine nitrogen were confirmed by XPS. Catalytic performance enhancement mechanisms were correlated with the redistribution of electrons at the interface between carbon material and cobalt atoms through the molecular dynamics method and a reaction mechanism was also proposed. The optimized catalysts showed outstanding catalytic activity and stability and no obvious decrease in activity was found after 6 cycles with 99.6% FUR conversion and 96% methyl 2-furoate selectivity.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 19524-06-2, you can contact me at any time and look forward to more communication. Name: 4-Bromopyridine hydrochloride.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

19524-06-2, Name is 4-Bromopyridine hydrochloride, molecular formula is C5H5BrClN, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Singh, Ovender, once mentioned the new application about 19524-06-2, Formula: C5H5BrClN.

A new family of complexes derived from bis(imino)pyridine-type ligands: Crystal structures and bio-molecular interaction studies

Bis(imino)pyridine (NNN)-type ligand [(PyPhime-Cina) = 2,6-bis((E)-1-phenyl-2-((E)-3-phenylallylidene)hydrazinyl)pyridine] was synthesized, and a new family of metal complexes [Mn(PyPhime-Cina)Cl2] (1), [Fe(PyPhime-Cina)Cl2] (2), [Co(PyPhime-Cina)Cl2] (3), [Ni(PyPhime-Cina)Cl2] (4), and [Cu(PyPhime-Cina)Cl2] (5), derived from the ligand, have been synthesized and characterized. Molecular structures of the ligand and complexes 1-5 were determined using X-ray crystallography. Electronic properties and frontier molecular orbitals of the complexes were investigated by DFT and TD-DFT calculations. DNA interaction studies were evaluated by UV-visible absorption, fluorescence and circular dichroism spectral studies which indicated noncovalent binding of complexes with CT-DNA. Hirshfeld surface analysis of all the complexes was studied to know the weak interaction present in the molecules.

If you’re interested in learning more about 19524-06-2. The above is the message from the blog manager. Formula: C5H5BrClN.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 19524-06-2, Name is 4-Bromopyridine hydrochloride, SMILES is BrC1=CC=NC=C1.[H]Cl, belongs to pyridine-derivatives compound. In a document, author is Yang, Lili, introduce the new discover, Recommanded Product: 4-Bromopyridine hydrochloride.

A unique formyl iodoargentate exhibiting luminescent and photocurrent response properties

A decomposition and self-assembly reaction affords a novel formyl iodoargentate [H2L](n)[Ag2I3(mu-CHO)](n) (1, L = 2,6-bis(1-imdazoly)pyridine) with an unprecedented CHO- link mode, which provides the only example of iodoargentate incorporating the unstable formyl species under hydrothermal conditions. 1 exhibits luminescent and photocurrent response properties.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 19524-06-2 is helpful to your research. Recommanded Product: 4-Bromopyridine hydrochloride.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem