Category: 19621-92-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below., Recommanded Product: 19621-92-2

To a solution of 6-hydroxypicolinic acid (13.0 g, 93.5 mmol) in methanol (150 mL) at room temperature was added HCl in dioxane (4N, 10 mL). The resulting mixture was stirred at room temperature for 48 hours. The reaction mixture was concentrated to give methyl 6-hydroxypicolinate (13 g, 90%) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19621-92-2, 6-Oxo-1,6-dihydropyridine-2-carboxylic acid.

Reference:
Patent; Ruf, Sven; Sadowski, Thorsten; Wirth, Klaus; Schreuder, Herman; Buning, Christian; Kallus, Christopher; Strobel, Hartmut; Wehlan, Hermut; US2014/296296; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 19621-92-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below.

Compound 1-193[00475] Compound 1-193 was synthesized as a yellow solid (33%) via the condensation of Compound 1-107 (1 equiv) with 6-hydroxypicolinic acid (3.0 equiv), HATU (2.5 equiv) and Hunig’s base (5 equiv) in acetonitrile at 45 C. Purification was carried out using Si02 chromatography employing a 0-40% (7:1 acetonitrile/MeOH)/DCM gradient following a DCM and sodium bicarbonate-based work-up.1H NMR (400 MHz, CD3OD) 8.85 (d, IH), 8.82-8.79 (m, 2H), 8.47 (s, IH), 8.02-7.98 (m, 2H), 7.62 (s, IH), 7.35-7.27 (m, IH), 7.14-7.06 (m, 2H), 7.05-6.95 (m, IH), 6.93 (d, IH), 6.04 (s, 2H) ppm. 1H NMR (400 MHz, CD3OD) 8.81 (d, IH), 8.45 (s, IH), 7.85-7.77 (m, IH), 7.77-7.40 (bs, IH), 7.55 (s, IH), 7.33-7.27 (m, IH), 7.13-7.05 (m, 2H), 6.98-6.93 (m, IH), 6.91 (d, IH), 6.91-6.86 (m, IH), 6.01 (s, 2H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19621-92-2, its application will become more common.

Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; KIM, Charles; NAKAI, Takashi; WAI-HO LEE, Thomas; MOORE, Joel; PERL, Nicholas, Robert; ROHDE, Jason; IYENGAR, Rajesh, R.; MERMERIAN, Ara; WO2012/3405; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 19621-92-2 ,Some common heterocyclic compound, 19621-92-2, molecular formula is C6H5NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The complex [RuH(CO)(6-OH-py-2-COO)(PPh3)2] (1) was synthesized by the reaction between [RuHCl(CO)(PPh3)3] (0.2 g, 2.0 × 10-4 mol) and 6-hydroxypyridine-2-carboxylic acid (0.031 g, 2.2 × 10-4 mol), and the complex [Ru(3-OH-py-2-COO)2(PPh3)2] (2) was synthesized by the reaction between [RuCl2(PPh3)3] (0.2 g, 2.0 × 10-4 mol) and 3-hydroxypyridine-2-carboxylic acid (0.061 g, 4.4 × 10-4 mol). The mixtures of the compounds were refluxed in methanol (60 mL) for 3 h. After this time, they were cooled and filtered. Crystals suitable for X-ray crystal analysis were obtained by slow evaporation of the reaction mixtures.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19621-92-2, its application will become more common.

Reference:
Article; Ma?ecki; Krompiec; Maro?; Penkala; Polyhedron; vol. 48; 1; (2012); p. 21 – 30;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 19621-92-2, Adding some certain compound to certain chemical reactions, such as: 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid,molecular formula is C6H5NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19621-92-2.

Ethyl iodide (112.2 g, 720 mmol, 4 equiv) was added to a suspension of 6-hydroxy – pyridme-2-carboxylic acid (25.0 g, 180 mmol, 1 equiv) and silver(I) carbonate (100 g, 360 mmol, 2 equiv) in CHCb (400 mL). The mixture was stirred at 30C for 1 day. Insoluble material was removed by filtration and the solid was washed with CHCb. The filtrate was concentrated in vacuo to afford the title compound ethyl 6-ethoxypicolinate as light yellow oil which was used in the next step without further purification. LC-MS: m/z 196.0 (M+H) +

According to the analysis of related databases, 19621-92-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANNAPURNA BIO, INC.; TANG, Haifeng; HANSON, Michael; BOYCE, Sarah; NIE, Zhe; (461 pag.)WO2020/73011; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, molecular formula is C6H5NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 19621-92-2

General procedure: To a stirred solution of 3-hydroxypicolinic acid (100 mg, 0.72 mmol), hydroxybenzotriazole (abbreviated HOBt, 194 mg, 1.44 mmol), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDCI, 276 mg, 1.44 mmol) in dimethylformamide (DMF, 5 mL) at rt was added N,N-diisopropylethylamine (DIPEA, 0.25 mL, 1.44 mmol) and (4-fluorophenyl) methanamine (0.18 mL, 1.44 mol). The reaction mixture was stirred at 50 C in microwave reactor for 2 h. After removal of most of the DMF, the residue which was purified by chromatography using ether/ethyl acetate (3:1) as eluent to give compound 1a (2a) as a white solid (166 mg, 94%), m.p. 71-73 C.

With the rapid development of chemical substances, we look forward to future research findings about 19621-92-2.

Reference:
Article; Zhang, Feng-Hua; Debnath, Bikash; Xu, Zhong-Liang; Yang, Liu-Meng; Song, Li-Rui; Zheng, Yong-Tang; Neamati, Nouri; Long, Ya-Qiu; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1051 – 1063;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 19621-92-2, 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, blongs to pyridine-derivatives compound. Safety of 6-Oxo-1,6-dihydropyridine-2-carboxylic acid

At 25 C and N 2 atmosphere,To 6-hydroxypyridine-2-carboxylic acid (12 mmol)And pyridine (20 mmol)Add 20 mL of anhydrous dichloromethane solution1,3-Dicyclohexylcarbodiimide DCC (15 mmol).5 minutes later,Add 2-((1-Amino-2-methylpropan-2-yl)amino)-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)ethanone (10 mmol ),The mixture was stirred overnight.TLC (95:5 in dichloromethane:Methanol containing 2% ammonia)Indicates that all raw materials are consumed.The reaction was quenched with sodium bicarbonate and filtered through a pad of Celite.The stopper was rinsed with methylene chloride.The aqueous layer was extracted with dichloromethane.After the combined organic layers are dried over Na 2 SO 4 ,Filter and concentrate in vacuo,This gave 3.5 g of a light brown solid.The crude product was purified by flash chromatography.Use 2% to 8% MeOH:Purification by stepwise gradient of dichloromethane and 2% ammonia,Obtained 3.2 g of white powder as N-(2-((2-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-2-ethoxy)amino)-2-methylpropane ()-(6-hydroxypyridin-2-yl)-carboxamide,The yield was 94%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19621-92-2, 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Sang Qi; (10 pag.)CN108218865; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem