Category: 197376-41-3

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 197376-41-3, name is Ethyl 2-(3-Bromo-2-pyridyl)acetate, molecular formula is C9H10BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 197376-41-3

Example 583-[4-Chloro-3-[[(tricyclo[3.3.1.13’7]dec-l-ylmethyl)amino]carbonyl]phenyl]-2-pyridineacetic acid, monosodium saltoCl[4-Chloro-3-[[(tricyclo[3.3.1.13’7]dec-l-ylmetliyl)amino]carbonyl]phenyl]-boronic acid(Example 2(a)) (142 mg), 3-bromo-2-pyridineacetic acid ethyl ester (Prepared according tothe method of Synthesis, 1997, 949-952) (100 mg), sodium carbonate (130 mg),te^rafaXtriphenylphosphme)paUadium(O) (10 mg), tetrahydrofuran (2 mL) and water (1mL) were heated in a microwave at 120 C for 30 minutes. 48% sodium hydroxide solution(200 uL) was added to the reaction which was stirred for 12 hours before being filtered.The solid was washed with water (3 mL) and then acetonitrile (3 mL) before being dried ina vacuum oven to afford the title compound as a solid (55 mg).MS: APCI(-ve) 437m.p. 186-1 87C dec.JH NMR (300 MHz, d6-DMSO) 5 8.61 (1H, t), 8.44 (1H, d), 7.72 (1H, dd), 7.61 – 7.55(2H, m), 7.49 (1H, d), 7.26 – 7.19 (1H, m), 3.29 (2H, s), 2.94 (2H, d), 1.93 (3H, s), 1.701.50(12H,m).

With the rapid development of chemical substances, we look forward to future research findings about 197376-41-3.

Reference:
Patent; ASTRAZENECA AB; WO2006/25783; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 197376-41-3, Ethyl 2-(3-Bromo-2-pyridyl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H10BrNO2, blongs to pyridine-derivatives compound. Formula: C9H10BrNO2

Compound 27 (37.7 g, 0.15 mol) was dissolved in dry acetonitrile (400 mL). DBU (28.2 g, 0.18 mol) was added followed by 4-acetamidobenzenesulfonyl azide (37.6 g, 0.15 mol). The solution was stuffed overnight. Water (3 L) was slowly added. The solid was filtered off on a sintered glass funnel and washed with additional water (1 L) and hexanes (0.5 L) and air dried on the fritted funnel for 2 h. The product was a cream solid (27.3 g). LCMS: [M+Hj=270.1.

The synthetic route of 197376-41-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KALA PHARMACEUTICALS, INC.; KIM, Jinsoo; NGUYEN, Minh N.; ENLOW, Elizabeth; ONG, Winston Z.; NOWAK, Pawel W.; FEUTRILL, John T.; WO2014/201127; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem