Category: 19755-53-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19755-53-4, name is 2-Bromo-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Bromo-3-nitropyridine

Example 16; 1-(2-(benzo[b]thiophen-2-yl)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea; 16a. 2-(benzo[b]thiophen-2-yl)-3-nitropyridine; To a solution of 2-bromo-3-nitropyridine (75 mg, 0.371 mmol) in DME (3 mL) was added benzofuran boronic acid (132 mg, 0.802 mmol), followed by Pd(PPh3)4 (35 mg, 0.03 mmol) and K2CO3 (145 mg, 1.05 mmol). The reaction mixture was stirred at 80 C. for 16 h. The mixture was filtered and washed with CH2Cl2 (10 mL). The solvent was evaporated under reduced pressure and purified by column chromatography using 0 to 80% EtOAc in hexane over 40 min as eluting gradient to afford 16a (38 mg, 40%) as a yellowish powder. MS (ES) m/z 257 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19755-53-4, 2-Bromo-3-nitropyridine.

Reference:
Patent; Bristol-Myers Squibb Company; US2006/293336; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 19755-53-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19755-53-4, name is 2-Bromo-3-nitropyridine. A new synthetic method of this compound is introduced below.

2. N-(4-TERT-BUTYL-PHENYL)-4- (3-NITRO-PYRIDIN-2-YL)-BERAZAMIDE Bubble nitrogen through a solution of 4-BORONO-N- (4-TERT-BUTYL-PHENYL)-BENZAMIDE (1.3 g, 4.37 mmol), 2-bromo-3-nitro-pyridine (0. 63 g, 3.12 mmol), 2M NA2CO3 (3.9 ml, 2.5 equivalents), in DME for 10 minutes. Add Pd (PPH3) 4 (144 mg) and bubble nitrogen through the solution for two additional minutes. Heat the reaction for 12 hours at 80C. Cool the reaction, concentrate, and partition between EtOAc and water. Dry the solution (Na2SO4) and concentrate under reduced pressure to give the crude product. Purify using chromatography (25% ethyl acetate/hexanes eluent) to give N- (4-tert-butyl-phenyl)-4- (3- nitro-pyridin-2-yl)-benzamide as a solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19755-53-4, 2-Bromo-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; NEUROGEN CORPORATION; WO2004/56774; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem