Category: 197958-29-5

《Discovery of the Potent Phosphoinositide 3-Kinase d (PI3 K d) Inhibitors》 was written by Lei, Tao; Hong, Yongwei; Chang, Xinyue; Zhang, Zhimin; Liu, Xingguo; Hu, Miao; Huang, Wenhai; Yang, Haiyan. Application In Synthesis of 2-Pyridinylboronic acid And the article was included in ChemistrySelect in 2020. The article conveys some information:

The PI3Kd plays a pivotal role in regulating immune cell function and has recently emerged as a promising therapeutic target in treating various diseases, which draw more and more attention to discover potent PI3Kd inhibitors in recent years. Starting from structure-based drug design, a series of derivatives were designed and synthesized as new chemotypes of PI3Kd inhibitors. The potential compounds were structurally optimized by interaction showed in docking study. In cell-free kinase activity assays, Homogeneous Time-Resolved Fluorescence Assay (HTRF) method was performed for evaluating the inhibitory activities against PI3Kd. Interestingly, the representative compound 4 exhibited potent PI3Kd activity (IC50=72 nM), which is comparable to that of pos. compound TGR1202. Furthermore, compound 4 showed 15-fold water solubility than TGR1202. In addition, the tests of compound 4 on anti-cancer activity against jeko-1 cancer cell line and cytotoxicity against peripheral blood mononuclear cell (PBMC) suggested high inhibition activity and low toxicity resp. A series of experiments indicated that compound 4 possessed novel chem. structure and high-efficiency PI3Kd inhibition activity, deserving further structural optimization to develop highly potent PI3Kd inhibitors. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Application In Synthesis of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Application In Synthesis of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Molecules included an article by Yuan, Chunling; Zheng, Li; Zhao, Yingdai. Safety of 2-Pyridinylboronic acid. The article was titled 《Cu(II)-catalyzed homocouplings of (hetero)arylboronic acids with the assistance of 2-O-methyl-D-glucopyranose》. The information in the text is summarized as follows:

This is the first report of a natural ligand improving the copper-catalyzed homocouplings of (hetero)arylboronic acids. Various important synthetic biaryl intermediates in organic synthesis could be assembled via this method. To gain insight into this reaction, in-situ React IR technol. was used to confirm the effectivity of this catalyst system. This protocol provides important biaryl compounds in high yields within a short time. In the experiment, the researchers used many compounds, for example, 2-Pyridinylboronic acid(cas: 197958-29-5Safety of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Krah, Sabrina; Kachel, Iris; Trapp, Oliver published an article in ChemCatChem. The title of the article was 《Electron-Rich Silicon Containing Phosphinanes for Rapid Pd-Catalyzed C-X Coupling Reactions》.Electric Literature of C5H6BNO2 The author mentioned the following in the article:

Novel silicon-containing phosphine, 4,1-phosphasilinane 2-TripC6H4P(CH2CH2)2SiMe2 (SabPhos, Trip = 2,4,6-iPr3C6H2) was prepared as a ligand for palladium-catalyzed coupling reactions. Palladium-catalyzed cross-coupling reactions are among the most useful and efficient methods for direct access to complex structures in organic synthesis. However, heteroatom-containing compounds can complicate such coupling reactions due to their competitive coordination with the palladium catalyst and electronic effects. As a result, good yields are often only obtained under harsher reaction conditions, such as high temperatures and long reaction times. Here the design of a highly active phosphine ligand is reported that provides excellent yields for C-N coupling reactions at ambient temperature Incorporation of the phosphorus atom into a cyclohexane ring maintains the pyramidal structure of the phosphorus while reducing steric hindrance. This, and a silicon atom in the cyclohexane moiety, results in an electron-rich phosphinane ligand. This novel silicon containing SabPhos ligand can be obtained in excellent yields in a straightforward synthesis. In palladium catalyzed reactions, this ligand facilitates the coupling of a broad range of heteroaryl chlorides via C-C bonds with boronic acids and C-N bonds with secondary amines in excellent yields under mild conditions. In the experiment, the researchers used 2-Pyridinylboronic acid(cas: 197958-29-5Electric Literature of C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Xia, Peng-Ju; Ye, Zhi-Peng; Hu, Yuan-Zhuo; Song, Dan; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Recommanded Product: 197958-29-5. The article was titled 《Photocatalytic, Phosphoranyl Radical-Mediated N-O Cleavage of Strained Cycloketone Oximesã€? The information in the text is summarized as follows:

In the presence of the iridium photocatalyst [Ir[dF(CF3)ppy]2(dtbbpy)]PF6, four-membered cyclic ketoximes such as cyclobutanone oxime underwent ring opening and addition reactions with aryl alkenes such as 1,1-diphenylethylene or with α-trifluoromethylstyrenes such as PhC(CF3):CH2 mediated by Ph3P (via its photogenerated phosphoranyl radical cation) under blue LED light to yield 6-arylhexanenitriles such as Ph2CH(CH2)4CN or (aryl)(difluoromethylene)hexanenitriles such as F2C:CPh(CH2)4CN. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Recommanded Product: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Xia, Peng-Ju; Ye, Zhi-Peng; Hu, Yuan-Zhuo; Song, Dan; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Recommanded Product: 197958-29-5. The article was titled 《Photocatalytic, Phosphoranyl Radical-Mediated N-O Cleavage of Strained Cycloketone Oximes》. The information in the text is summarized as follows:

In the presence of the iridium photocatalyst [Ir[dF(CF3)ppy]2(dtbbpy)]PF6, four-membered cyclic ketoximes such as cyclobutanone oxime underwent ring opening and addition reactions with aryl alkenes such as 1,1-diphenylethylene or with α-trifluoromethylstyrenes such as PhC(CF3):CH2 mediated by Ph3P (via its photogenerated phosphoranyl radical cation) under blue LED light to yield 6-arylhexanenitriles such as Ph2CH(CH2)4CN or (aryl)(difluoromethylene)hexanenitriles such as F2C:CPh(CH2)4CN. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Recommanded Product: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Xiaoyu; Wang, Liang; Hu, Fangzhi; Xu, Lubin; Li, Sanming; Li, Shuai-Shuai published their research in Organic Letters in 2021. The article was titled 《Redox-triggered switchable synthesis of 3,4-dihydroquinolin-2(1H)-one derivatives via hydride transfer/N-dealkylation/N-acylation》.Reference of 2-Pyridinylboronic acid The article contains the following contents:

The switchable synthesis of 3-non, 3-mono, 3,3′-disubstituted 3,4-dihydroquinolin-2(1H)-ones was developed through a redox-neutral hydride-transfer/N-dealkylation/N-acylation strategy from o-aminobenzaldehyde with 4-hydroxycoumarin, and Meldrum’s acid, resp. The unprecedented strategy for the synthesis of 3,3′-highly functionalized 3,4-dihydroquinolin-2(1H)-one has been realized with the in situ utilization of the released HCHO via the o-QM involved Michael addition In addition, the synthetic utility of this protocol has been well illustrated via concise synthesis of CYP11B2 inhibitor. In addition to this study using 2-Pyridinylboronic acid, there are many other studies that have used 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martinez, Kristina; Benson, Kaitlyn; Paul, Jared; Schmehl, Russell H. published an article in 2021. The article was titled 《Photophysics of Ru(II) complexes with hydroxylated diimine ligands: Photoinduced electron/proton transfer to anthraquinone》, and you may find the article in Polyhedron.Application In Synthesis of 2-Pyridinylboronic acid The information in the text is summarized as follows:

This manuscript reports the reaction of the 3MLCT excited states of two luminescent chromophores, [(bpy)2Ru(OHbpy)]2+ and [(bpy)2Ru(OMebpy)]2+ (bpy = 2,2′-bipyridine, OHbpy = 4-hydroxy-2,2′-bipyridine, OMebpy = 4-methoxy-2,2′-bipyridine), with anthraquinone (AQ). A series of luminescence, electrochem., spectrophotometric and transient absorption studies were done in order to determine free energies for the potential reaction paths between the photoexcited complexes and AQ. For the OMebpy complex, only excited state electron transfer (ET*) from the 3MLCT state of the complex to AQ was possible. However, for the OHbpy complex, the excited state could react with AQ via a variety of pathways including excited state electron transfer, ET*, excited state proton transfer (PT*) and excited state proton coupled electron transfer (PCET*). The thermodn. anal. revealed that, for the OHbpy complex PT* was very endergonic and not a viable reaction pathway, however both ET* and PCET* could occur. Luminescence quenching studies revealed that both the OHbpy and the OMebpy excited complexes reacted with AQ (kq ∼ 109 M-1s-1 for both). Transient absorption anal. showed that, for the OMebpy complex, no photoproducts escaped the encounter complex associated with the quenching reaction. The result is consistent with strong electrostatic association of the 3+/1- encounter complex. For the OHbpy complex transient absorption results clearly show the formation of PCET* products from the encounter complex. The result represents one of a small number of examples of excited states of chromophores reacting via proton coupled electron transfer within an encounter complex. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Application In Synthesis of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Green Chemistry included an article by Yamada, Makito; Shio, Yasunori; Akiyama, Toshiki; Honma, Tetsuo; Ohki, Yuuta; Takahashi, Naoyuki; Murai, Kenichi; Arisawa, Mitsuhiro. Computed Properties of C5H6BNO2. The article was titled 《Ligand-free Suzuki-Miyaura coupling reaction of aryl chlorides using a continuous irradiation type microwave and a palladium nanoparticle catalyst: effect of a co-existing solid》. The information in the text is summarized as follows:

The effect of a co-existing metal in the ligand-free Suzuki-Miyaura coupling reaction of aryl chlorides ArCl (Ar = Ph, pyridin-2-yl, naphthalen-1-yl, etc.) is promoted by a ”continuous irradiation type microwave” and a ”palladium nanoparticle catalyst”, and it is found that the co-existing metal affects this reaction due to its absorption ability of microwave energy in the reaction system. It is also observed that spiking occurred more frequently in the presence of a co-existing metal. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Computed Properties of C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem