Category: 197958-29-5

Oh, Sangmi; Kwon, Do Yoon; Choi, Inhee; Kim, Young Mi; Lee, Ji Young; Ryu, Jiyoung; Jeong, Hangyeol; Kim, Myung Jin; Song, Rita published an article in 2021. The article was titled 《Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities》, and you may find the article in ACS Medicinal Chemistry Letters.COA of Formula: C5H6BNO2 The information in the text is summarized as follows:

This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5COA of Formula: C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors》 were Huang, Chao; Xiong, Juan; Guan, Hui-Da; Wang, Chang-Hong; Lei, Xinsheng; Hu, Jin-Feng. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Quality Control of 2-Pyridinylboronic acid The author mentioned the following in the article:

Nonracemic hydroxydihydroisobenzopyranones such as I, analogs of (R)-5-methylmellein, were prepared and tested as inhibitors of monoamine oxidase A (MAO-A). Most of the hydroxydihydrobenzopyranones selectively inhibited MAO-A with IC50 values of 60 nM to 29 μM; I was the most potent and selective analog prepared, with IC50 values of 60 nM for MAO-A and >50 μM for MAO-B. Mol. docking calculations of I in the active sites of MAO-A and MAO-B were performed; the kinetics of inhibition of MAO-A by I were determined In the experimental materials used by the author, we found 2-Pyridinylboronic acid(cas: 197958-29-5Quality Control of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Using fluoroform for constructing aromatic and heterocyclic trifluoromethylselenyl compounds》 was written by Aharon, Cheryl; Rozen, Shlomo. SDS of cas: 197958-29-5This research focused ontrifluoromethylselenium compound preparation; aromatic selenium cyanide trifluoromethyl copper trifluoromethylation; heterocyclic selenium cyanide trifluoromethyl copper trifluoromethylation. The article conveys some information:

Fluoroform is used to prepare CuCF3 according to literature procedures. This nucleophilic trifluoromethyl moiety was reacted with aromatic and heterocyclic selenium cyanide derivatives 3-R-4-N(R1)(R2)-5-R3C6H2SeCN (R = H, Me, Br; R1 = H, Et, Ac; R2 = H, Et, Ac; R3 = H, Me), 3-R4-4-R5-C6H3SeCN (R4 = H, Me; R5 = Me, t-Bu, Cl, etc.), I (R6 = H, Br; R7 = H, SeCN; R8 = H, SeCN) and II (X = O, S) resp. to form the corresponding trifluoromethylselenium compounds 3-R-4-N(R1)(R2)-5-R3C6H2SeCF3, 3-R4-4-R5-C6H3SeCF3, III (R9 = H, SeCF3; R10 = H, SeCF3) and IV. Selenium cyanides were made with 1,3-dicyanotriselenide prepared in situ from malononitrile and selenium dioxide. The electrophilicity of the reagent (δ+SeCN) was enough to attack aniline derivatives 3-R-4-N(R1)(R2)-5-R3C6H3 at the para position, but with other aromatics it was advantageous to use the corresponding boronic acids 3-R4-4-R5-C6H3B(OH)2, V (R11 = H, B(OH)2; R12 = H, B(OH)2) and VI as the moiety was easily displaced by the selenium cyanate moiety. In addition to this study using 2-Pyridinylboronic acid, there are many other studies that have used 2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Han, Sang Hoon; Goins, Christopher M.; Arya, Tarun; Shin, Woo-Jin; Maw, Joshua; Hooper, Alice; Sonawane, Dhiraj P.; Porter, Matthew R.; Bannister, Breyanne E.; Crouch, Rachel D.; Lindsey, A. Abigail; Lakatos, Gabriella; Martinez, Steven R.; Alvarado, Joseph; Akers, Wendell S.; Wang, Nancy S.; Jung, Jae U.; Macdonald, Jonathan D.; Stauffer, Shaun R. published an article in Journal of Medicinal Chemistry. The title of the article was 《Structure-based optimization of ML300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CLpro)》.Reference of 2-Pyridinylboronic acid The author mentioned the following in the article:

Starting from the MLPCN probe compound ML300, a structure-based optimization campaign was initiated against the recent severe acute respiratory syndrome coronavirus (SARS-CoV-2) main protease (3CLpro). X-ray structures of SARS-CoV-1 and SARS-CoV-2 3CLpro enzymes in complex with multiple ML300-based inhibitors, including the original probe ML300, were obtained and proved instrumental in guiding chem. toward probe compound 41 (I)(CCF0058981). The disclosed inhibitors utilize a noncovalent mode of action and complex in a noncanonical binding mode not observed by peptidic 3CLpro inhibitors. In vitro DMPK profiling highlights key areas where further optimization in the series is required to obtain useful in vivo probes. Antiviral activity was established using a SARS-CoV-2-infected Vero E6 cell viability assay and a plaque formation assay. I demonstrates nanomolar activity in these resp. assays, comparable in potency to remdesivir. These findings have implications for antiviral development to combat current and future SARS-like zoonotic coronavirus outbreaks. In addition to this study using 2-Pyridinylboronic acid, there are many other studies that have used 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-Pyridinylboronic acidIn 2021 ,《Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis》 appeared in Journal of Medicinal Chemistry. The author of the article were Thomas, Michael; Brand, Stephen; De Rycker, Manu; Zuccotto, Fabio; Lukac, Iva; Dodd, Peter G.; Ko, Eun-Jung; Manthri, Sujatha; McGonagle, Kate; Osuna-Cabello, Maria; Riley, Jennifer; Pont, Caterina; Simeons, Frederick; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Viayna, Elisabet; Fiandor, Jose M.; Martin, Julio; Wyatt, Paul G.; Miles, Timothy J.; Read, Kevin D.; Marco, Maria; Gilbert, Ian H.. The article conveys some information:

There is an urgent need for new treatments for visceral leishmaniasis (VL), a parasitic infection which impacts heavily large areas of East Africa, Asia, and South America. We previously reported on the discovery of GSK3494245/DDD01305143 (1) as a preclin. candidate for VL and, herein, we report on the medicinal chem. program that led to its identification. A hit from a phenotypic screen was optimized to give a compound with in vivo efficacy, which was hampered by poor solubility and genotoxicity. The work on the original scaffold failed to lead to developable compounds, so an extensive scaffold-hopping exercise involving medicinal chem. design, in silico profiling, and subsequent synthesis was utilized, leading to the preclin. candidate. The compound was shown to act via proteasome inhibition, and we report on the modeling of different scaffolds into a cryo-EM structure and the impact this has on our understanding of the series’ structure-activity relationships. In the experiment, the researchers used many compounds, for example, 2-Pyridinylboronic acid(cas: 197958-29-5Application In Synthesis of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Letters in Organic Chemistry included an article by Gavhane, Dinesh S.; Sarkate, Aniket P.; Karnik, Kshipra S.; Jagtap, Shritesh D.; Ansari, Sajed H.; Izankar, Ashwini V.; Narula, Ishudeep K.; Jambhorkar, Vaishnavi S.; Rajhans, Aishwarya P.. Computed Properties of C5H6BNO2. The article was titled 《Nano Copper Catalyzed Microwave Assisted Coupling of Benzene Boronic Acids with Thiophenols》. The information in the text is summarized as follows:

A proficient, microwave mediated methodol. using CuFe2O4 nanoparticle as the catalyst for S-arylation of substituted benzene boronic acids with thiophenol was developed. In this method, the substituted thioethers were easily obtained through a C-S bond formation using microwave irradiation technique as well as conventional heating in the presence of CuFe2O4 nanoparticles with modest to excellent yields with the less reaction time. The ligand free microwave technique helped in the preparation of substituted thioethers in measurable amount within 10 mins. The same results were obtained with conventional heating in 12h. The reported method was economically efficient and an alternative to the initial existing method for the preparation of substituted thioethers. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Computed Properties of C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kolekar, Yuvraj A.; Bhanage, Bhalchandra M. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Pd-Catalyzed Oxidative Aminocarbonylation of Arylboronic Acids with Unreactive Tertiary Amines via C-N Bond Activation》.Recommanded Product: 2-Pyridinylboronic acid The article contains the following contents:

An efficient synthesis of tertiary amides from aryl boronic acids and inert tertiary amines through the oxidative carbonylation via C(sp3)-N bond activation is presented. This protocol significantly restricts the homocoupling biarylketone product. It involves the use of a homogeneous PdCl2/CuI catalyst and a heterogeneous Pd/C based catalyst, which promotes C(sp3)-N bond activation of tertiary amines with aryl boronic acids. This process represents a ligand-free, base-free, and recyclable catalyst along with an ideal oxidant like mol. oxygen. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Recommanded Product: 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-Pyridinylboronic acidIn 2020 ,《Green-Synthesized Nickel Nanoparticles on Reduced Graphene Oxide as an Active and Selective Catalyst for Suzuki and Glaser-Hay Coupling Reactions》 appeared in Applied Organometallic Chemistry. The author of the article were Murugan, Karthik; Nainamalai, Devarajan; Kanagaraj, Pavithara; Nagappan, Saravana Ganesan; Palaniswamy, Suresh. The article conveys some information:

The present work disclosed the potential catalytic application of the as-prepared RGO-Ni nanocomposite in Csp2-Csp2 Suzuki type homocoupling and Csp-Csp Glaser-Hay coupling reactions. A mild and benign methodol. to synthesize biaryls Ar-Ar [Ar = Ph, 3-MeOC6H4, 2-pyridyl, etc.] and 1,3-diynes R-CC-CC-R [R = t-Bu, 3-FC6H4, 4-EtC6H4, etc.] was demonstrated using the nickel nanoparticles supported on reduced graphene oxide (RGO-Ni) as a heterogeneous catalyst which was prepared using green reagents. A series of substituted biaryls Ar-Ar and 1,3-diynes R-CC-CC-R was synthesized in good to excellent yields via reduced graphene oxide supported nickel nanoparticles catalyzed Suzuki coupling of arylboronic acids and Glaser-Hay coupling of terminal alkynes resp. using 1,4-dioxane as a benign solvent. The present ligand-free catalytic system proceeded smoothly under mild conditions, avoided noble and stoichiometric metal reagents and tolerated sensitive functional groups such as nitrogen and sulfur containing heteroaryl boronic acids. Hot filtration test unambiguously proved the true heterogeneity of the catalyst and which supported for the further reusability of the catalyst for several times without any change in the activity. The easy preparation and simple magnetic separation, stability and reusability revealed that as-prepared RGO-Ni as a versatile catalyst for the synthesis of polyaromatic compounds both in academia and industries. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fang, Zhen; Liu, Yang; Zhang, Rong; Chen, Qiang; Wang, Tianqi; Yang, Wei; Fan, Yan; Yu, Chundong; Xiang, Rong; Yang, Shengyong published an article in 2021. The article was titled 《Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D》, and you may find the article in European Journal of Medicinal Chemistry.Reference of 2-Pyridinylboronic acid The information in the text is summarized as follows:

Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of tumorigenesis, progression and drug resistance and has been considered a potential target for cancer treatment. However, there is still a lack of potent and selective KDM4D inhibitors. In this investigation, we report a new class of KDM4D inhibitors containing the 2-(aryl(pyrrolidine-1-yl)methyl)phenol scaffold, identified through AlphaLisa-based screening, structural optimization, and structure-activity relationship analyses. Among these inhibitors, 24s (I) was the most potent, with an IC50 value of 0.023 ± 0.004μM. This compound exhibited more than 1500-fold selectivity towards KDM4D vs. KDM4A as well as other JMJD subfamily members, indicating good selectivity for KDM4D. Kinetic anal. indicated that 24s did not occupy the 2-oxoglutarate binding pocket. In an in vitro assay, 24s significantly suppressed the proliferation and migration of colorectal cancer (CRC) cells. Overall, this study has identified a good tool compound to explore the biol. function of KDM4D and a good lead compound for drug discovery targeting KDM4D. After reading the article, we found that the author used 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and Structure-Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects》 was written by Vekariya, Rakesh H.; Lei, Wei; Ray, Abhisek; Saini, Surendra K.; Zhang, Sixue; Molnar, Gabriella; Barlow, Deborah; Karlage, Kelly L.; Bilsky, Edward J.; Houseknecht, Karen L.; Largent-Milnes, Tally M.; Streicher, John M.; Ananthan, Subramaniam. Related Products of 197958-29-5 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

We previously identified a pyridomorphinan (6, SRI-22138) possessing a 4-chlorophenyl substituent at the 5′-position on the pyridine and a 3-phenylpropoxy at the 14-position of the morphinan as a mixed μ opioid receptor (MOR) agonist and δ/κ opioid receptor (DOR/KOR) antagonist with potent antinociceptive activity and diminished tolerance and dependence in rodents. Structural variations at the 5′- and 14-positions of this mol. gave insights into the structure-activity relationships for binding and functional activity. Subtle structural changes exerted significant influence, particularly on the ability of the compounds to function as agonists at the MOR. In vivo evaluation identified compound 20(I) (SRI-39067) as a MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in tail-flick assay in mice, with diminished tolerance, dependence/withdrawal, reward liability, and respiratory depression vs. morphine. These results support the hypothesis that mixed MOR agonist/DOR antagonist ligands may emerge as novel opioid analgesics with reduced side effects. The experimental part of the paper was very detailed, including the reaction process of 2-Pyridinylboronic acid(cas: 197958-29-5Related Products of 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem