19798-77-7 | Pyridine-derivatives

09/22/21 News Extended knowledge of 19798-77-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Application of 19798-77-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19798-77-7, name is 4-Amino-3-chloropyridine. A new synthetic method of this compound is introduced below.

To a (100 ml_) round bottom flask was added 2-(5-iodo-3-methyl- 4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7(4H)-yl)acetic acid (1.2 g, 3.60 mmol), HATU (1.370 g, 3.60 mmol) and 4-amino-3-chloropyridine (0.695 g, 5.40 mmol). N,N- dimethylformamide (DMF) (Volume: 7 mL) was added. The mixture was stirred at room temperature for 2 hrs after which an additional amount HATU (0.5 eqv) was added until reaction was judged complete by LCMS. A mixture of EtOAc/Hexanes (50 ml, 1 :4) was added and the crude mixture stirred for an additional 5 minutes. The top layer was decanted and the resulting mixture was treated with 50 mL of water. The resulting precipitate was filtered, dried under vacuum at 45-50C to afford the desired product (1.582g, 95% yield); LCMS [M+H]+ 444.99.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2 Sep 2021 News Some tips on 19798-77-7

Statistics shows that 19798-77-7 is playing an increasingly important role. we look forward to future research findings about 4-Amino-3-chloropyridine.

Electric Literature of 19798-77-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.

General procedure: To a solution of substituted acetylsalicyloyl chlorides (0.022 mol) in anhydrous chloroform (100 mL) was added triethylamine (0.023 mol) at 4 C. After the mixture was stirred for 5-15 min and then substituted 4-amino pyridinewas added portion wise in the ice bath. After warmed to room temperature, the solution was stirred for 24-48 h and then quenched by 1 mL of 1 M hydrochloric acid. The reaction mixture was extracted with 10 % hydrochloric acid (50, 30and 30 mL) and the combined aqueous was basified to pH 7-9 with cooled saturated sodium bicarbonate solution. The yellow precipitation was filtered producing the crude products. After recrystallized in ethanol, the products were isolated as pure form in more than 85 % yields.

Statistics shows that 19798-77-7 is playing an increasingly important role. we look forward to future research findings about 4-Amino-3-chloropyridine.

Reference:
Article; Dian, He; Zhou, De-Bin; Mou, Jian-Ping; Yang, Zhu-Qing; Zhong, Jia; Ding, Xiao-Quan; Li, Chong; Wang, Xiao-Hong; Zhang, Jian-Gang; Asian Journal of Chemistry; vol. 26; 21; (2014); p. 7269 – 7275;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 19798-77-7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-77-7, 4-Amino-3-chloropyridine.

Application of 19798-77-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In the second step, the first step product 2- (1-pentyl-1H-indol-3-yl) acetic acid was added to dichloromethane (20 mL)EDCI (1.27 g) was added at room temperature,Stirring dissolved;3-Chloro-4-aminopyridine (0.9 g) was added,DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.(10 mL) was stirred for 10 min, and the organic phase was added with saturated brine (10 mL) for 10 min.The organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to give a pale yellow gum N- (3-chloropyridin-4-yl) -2- (1-pentyl-1H-indol-3-yl) acetamide (1.3 g).

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Chen Qing; Chen Minghua; Ba Mingyu; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107151223; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Simple exploration of 4-Amino-3-chloropyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19798-77-7, 4-Amino-3-chloropyridine, other downstream synthetic routes, hurry up and to see.

Application of 19798-77-7 ,Some common heterocyclic compound, 19798-77-7, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 100mL three-necked flask was added 3-chloro-4-aminopyridine 1.3g (10. Ommo 1),Dichloromethane 30ml,Ice water bath cooled to 0 ~ 5 C,Dropping 1)Step prepared phenazine-1-carboxylic acid chloride(11.2mm0l) in dichloromethane, after the addition was completed, incubated 0 ~ 5 C reaction lh, point plate monitoring, the reaction was complete. The solvent was removed by adding 50 ml of methylene chloride and the organic layer was sufficiently washed with a 5% aqueous hydrochloric acid solution. The organic layer was separated and the organic layer was washed with a 5% aqueous sodium hydroxide solution. The organic layer was separated and dried over anhydrous sodium sulfate 1 hour, suction filtration, the filtrate was stripped to obtain the amide 3.15g. Yield 94%

Reference:
Patent; Yangtze University; Wu Qinglai; Qin Chuan; Li Junkai; (36 pag.)CN107459490; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New downstream synthetic route of 19798-77-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 19798-77-7, 4-Amino-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Amino-3-chloropyridine, blongs to pyridine-derivatives compound. name: 4-Amino-3-chloropyridine

In a second step, the first step of the product 2- [1- (2-methylbutyl) -1H-indol-3-yl] acetic acid was added to dichloromethane(20 mL) and stirred at room temperature. EDCI (1.27 g) (10g) wasstirred for 10 min, and the organic phase was added to saturated brine(10 mL), and the mixture was stirred at room temperature for 3 h.The organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to giveN- (3-chloropyridin-4-yl) -2- [1- (Methylbutyl) -1H-indol-3-yl] acetamide (1.4 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Chen Qing; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107174581; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: 19798-77-7

Related Products of 19798-77-7 ,Some common heterocyclic compound, 19798-77-7, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sources of common compounds: 19798-77-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19798-77-7, 4-Amino-3-chloropyridine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19798-77-7, name is 4-Amino-3-chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Amino-3-chloropyridine

In the second step, the first step product 2- (1-butyl-1H-indol-3-yl) acetic acid was added to dichloromethane (20 mL)EDCI (1.27 g) was added at room temperature,Stirring dissolved;3-Chloro-4-aminopyridine (0.9 g) was added,DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.Add water (10mL) for 10min,The organic phase was added to saturated brine (10 mL) for 10 min,The organic phase was separated by column chromatography,Eluting with ethyl acetate-petroleum ether (1: 3)To give a pale yellow solidN- (3-chloropyridin-4-yl) -2- (1-butyl-1H-indol-3-yl) acetamide (1.3 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19798-77-7, 4-Amino-3-chloropyridine.

Brief introduction of 4-Amino-3-chloropyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-77-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 19798-77-7, 4-Amino-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19798-77-7, blongs to pyridine-derivatives compound. Recommanded Product: 19798-77-7

EXAMPLE 60 7-[(3-chloropyridin-4-yl)amino]-5-{[2-metlioxy-4-(piperazin-l -yl)phenyl]amino}pyrid d]pyridazin-4(3H)-one EXAMPLE 60A tert-butyl 4-(4-(7-(3 hloropyridin-4-ylamino)-4-oxo-3,4-dihydropyrido|3,4-i ]pyridazin-5- ylamino)-3-methoxyphenyl)piperazine- l -carboxylate A mixture of EXAMPLE 24A (160 mg, 0.33 mmol), 3-chloropyridin-4-amine (65 mg, 0.45 mmol), tris(dibenzylideneacetone)dipalladium (30 mg, 0.03 mmol),dimethylbisdiphenyl phosphinoxanthene (20 mg, 0.03 mmol), potassium r/-butoxide (1 12 mg, 1 mmol) and /erf-butanol (2 mL) was bubbled with nitrogen and heated at 100C for 18 hours. The mixture was concentrated and the residue was dissolved in dichloromethane, washed with saturated aqueous sodium bicarbonate and brine, dried over sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with 98/2 dichloromethane/methanol to give the title compound. MS : 579 (M + H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-77-7, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 19798-77-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-77-7, its application will become more common.

Application of 19798-77-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 19798-77-7 as follows.

In the second step, the first step product 2- [1- (2-cyanoethyl) -1H-indol-3-yl] acetic acid was added to dichloromethane (20 mL)EDCI (1.27 g) was added at room temperature,Stirring dissolved;3-Chloro-4-aminopyridine (0.9 g) was added,DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.(10 mL) was stirred for 10 min, and the organic phase was added with saturated brine (10 mL) for 10 min.The organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to give a pale yellow solidN- (3-chloropyridin-4-yl) -2- [1- (2-cyanoethyl) -1H-indol-3-yl] acetamide (0.8 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-77-7, its application will become more common.