Category: 19798-77-7

Synthetic Route of 19798-77-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.

The second step,2- (4-methoxy-1H-indol-3-yl) -2-carbonylacetyl chloride was added to dichloromethane (20 mL)Solution, cooling to 0 ~ 5 stirring. A solution of 3-chloro-4-aminopyridine (1.28 g) and triethylamine (1.5 g) was added slowly to room temperature for 2 h. Cooling to 0 ~ 5 stirring 30min, filtration, filter cake with dichloromethane (5mL) washing; 40 blast drying to light yellow solid2- (4-methoxy-1H-indol-3-yl) -N- (3-chloropyridin-4-yl) -2-carbonylacetamide (2.0 g).

The chemical industry reduces the impact on the environment during synthesis 19798-77-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Yang Ying; Zhu Chenggen; Chen Qing; Jiang Jiandong; Cao Yingli; Guo Qinglan; Zhang Chao; Lin Sheng; Tang Ke; Yang Yongchun; Guo Jiamei; (140 pag.)CN107149603; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 19798-77-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.

first step,Indole acetic acid (1.05 g)Was added to dichloromethane (20 mL) and stirred and stirred,EDCI (1.27 g) was added at room temperature,3-chloro-4-aminopyridine (0.85 g), DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.Add deionized water (20 mL) for 10 min,The organic phase was stirred for 10 min with saturated brine (10 mL)The organic phase was removed at 40 C under reduced pressure to give the crude N- (3-chloropyridin-4-yl) -2- (1H-indol-3-yl) acetamide as a pale reddish brown oil.

Statistics shows that 19798-77-7 is playing an increasingly important role. we look forward to future research findings about 4-Amino-3-chloropyridine.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Yang Ying; Zhu Chenggen; Chen Qing; Jiang Jiandong; Cao Yingli; Guo Qinglan; Zhang Chao; Lin Sheng; Tang Ke; Yang Yongchun; Guo Jiamei; (140 pag.)CN107149603; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19798-77-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In the second step, the first step of the product 2- [1- (pentyl-4-en-1-yl) -1H-indol-3-yl] acetic acid was added to dichloromethane (20 mL) and stirred at room temperature (1.27 g), stirred and dissolved;3-Chloro-4-aminopyridine (0.9 g) was added,DMAP (0.15 g), stirred at room temperature for 3 h;Add water (10mL) for 10min,The organic phase was stirred for 10 min and the organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to give red-brown gum N- (3 Yl) -2-yl] -2- (1- (3-pentyl-4-en-1-yl) -1H-indol-3-yl] acetamide (1.3 g).

According to the analysis of related databases, 19798-77-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Chen Qing; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (45 pag.)CN107151231; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem