Category: 19798-80-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19798-80-2, name is 4-Chloropyridin-2-amine. A new synthetic method of this compound is introduced below., Formula: C5H5ClN2

Step 1 : To a solution of 4-chloropyridin-2-amine (3 g, 23.2 mmol) in DMSO (60 mL) was added sodium methoxide (12.6 g, 232 mmol) and the mixture was then stirred at 150 C for 3 hours then poured into ice- water. The product was extracted with EtOAc (2×100 mL), and the combined organic layers were washed with water (50 mL) and brine (50 mL), dried (Na2S04) and concentrated. The residue was purified by silica gel chromatography using a solvent system of 50% petroleum ether/EtOAc to give 4-methoxypyridin-2 -amine (460 mg, 16%) as a yellow solid MS ESI calcd for C6H8N20 [M + H]+ 125, found 125.

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Reference:
Patent; MERCK SHARP & DOHME CORP.; ROMEO, Eric Thomas; MACHACEK, Michelle, R.; TROTTER, Benjamin Wesley; MILLER, Thomas Allen; ANDRESEN, Brian Michael; ANTHONY, Neville John; TAOKA, Brandon, M.; LIU, Yuan; WO2012/151137; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 19798-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-80-2, name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-chloropyridin-2-amine (3 g, 23.2 mmol) in DMSO (60 mL) was added sodium methoxide (12.6 g, 232 mmol) and the mixture was then stirred at 150 C for 3 hours then poured into ice-water. The product was extracted with EtOAc (2×100 mL), and the combined organic layers were washed with water (50 mL) and brine (50 mL), dried (Na2S04) and concentrated. The residue was purified by silica gel chromatography using a solvent system of 50% petroleum ether/EtOAc to give 4-methoxypyridin-2-amine (460 mg, 16%) as a yellow solid MS ESI calc’d for C6H8N20 [M + H]+ 125, found 125.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-80-2, 4-Chloropyridin-2-amine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ANDRESEN, Brian, M.; ANTHONY, Neville, J.; MILLER, Thomas, A.; WO2014/74422; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 19798-80-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19798-80-2, name is 4-Chloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-amino-4-chloropyridine (150 g, 0.78 mol) in DMF (1.5 L) was added NIS (341 g, 1.52 mol) and the reaction mixture stirred at RT for 18 h before being concentrated in vacuo to 300 mL volume. The resultant residue was poured into 10% aqueous sodium thiosulfate solution (1.2 L), stirred for 15 min and the precipitate formed collected by filtration, washed with water then dried at 35 C. in vacuo to give the title compound as a pale brown solid (185 g, 62%). 1H NMR 400 MHz (CDCl3) delta: 8.33 (1H, s), 6.68 (1H, s), 4.52 (2H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-80-2, 4-Chloropyridin-2-amine.

Reference:
Patent; Genentech, Inc.; US2012/245144; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19798-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-80-2, name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 4-chloropyridin-2-amine (8 g, 62.2 mmol) in acetonitrile (600 mL) at rt was added NBS (11.08 g, 62.2 mmol) in portions and the reaction was stirred for 14 h. The reaction mixture was concentrated under reduced pressure. The residue was reconstituted in ethyl acetate and water. The organics were extracted with ethyl acetate (3*50 mL). The combined organic layers were washed with water (100 mL), brine (100 mL), and dried over sodium sulphate. The organics were concentrated under reduced pressure to afford 5-bromo-4-chloropyridin-2-amine as yellow solid (13 g, 99% yield) that was used without further purification in the next step. LCMS (ESI) m/e 207.0 [(M+H)+, calcd for C5H5BrClN2 206.9]; LC/MS retention time (method B): tR=0.8 min; 1H NMR (400 MHz, CDCl3) delta 8.17 (s, 1H), 6.63 (s, 1H), 4.59 (s, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-80-2, 4-Chloropyridin-2-amine.

Reference:
Patent; Bristol-Myers Squibb Company; Vrudhula, Vivekananda M.; Pan, Senliang; Rajamani, Ramkumar; Macor, John E.; Bronson, Joanne J.; Dzierba, Carolyn Diane; Nara, Susheel Jethanand; Karatholuvhu, Maheswaran Sivasamban; US2013/237555; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 19798-80-2, 4-Chloropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19798-80-2, blongs to pyridine-derivatives compound. Quality Control of 4-Chloropyridin-2-amine

To a solution of 4-chloropyridin-2-amine (5.0 g, 39 mmol) in MeCN (200 mL) at 0 C was added B (2.2 mL, 43 mmol) in portions over a period of 30 min. The reaction was warmed to rt and stirred overnight. The solid was filtered, washed with hexane (3x), and dried to afford Intermediate 12A (9.1 g, 81%) as an off-white solid. LC-MS (ESI) m/z: 206.9/208.9 [M+H]+; ‘H NMR (400MHZ, DMSO-d6) delta 8.30 (s, 1H), 7.02 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-80-2, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; QUAN, Mimi L.; HU, Zilun; WANG, Cailan; PATIL, Sharanabasappa; WO2015/2915; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19798-80-2 , The common heterocyclic compound, 19798-80-2, name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of LHMDS (1M in THF, 17.11 mL, 17.11 mmol) in THF (5 mL) at -5 C was added a solution of 4-chloropyridin-2-amine (1 g, 7.78 mmol) in THF (5 mL) and the mixture was stirred for 5 min. To this mixture was added a solution of BOC2O (1.898 mL, 8.18 mmol) in THF (5 mL). The mixture was stirred at 0 C for 2 h and quenched by addition of aqueous NH4Cl. The pH of the solution was adjusted to 6 by addition of 1.5N HCl and extracted with ethyl acetate (3×15 mL). The combined organic extracts were washed with sodium bicarbonate (15 mL), water (15 mL) and brine (15 mL). The combined organic extracts were dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate, petroleum ether gradient) to yield tert-butyl (4-chloropyridin-2-yl)carbamate (1.435 g, 6.28 mmol, 81% yield).

The synthetic route of 19798-80-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol – Myers Squibb Company; Vivekanand, M.Burda; Pan, Senrian; Ramkumar, Rajamani; Sushil, Jetanand Nara; Maheswaran, Shibasanban Calatrava; Tarun Kumar, Meishar; Jonathan, L. Ditta; Carolyn, Diane Jiaba; John, J. Bronson; John, E. Maco; (232 pag.)JP2015/528018; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 19798-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-80-2, name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5.2.2.30 7,8-Dichloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione (30) To a solution of 2-amino-4-chloropyridine (1.28 g, 10.0 mmol) in DMF (40 mL) at -20 C was added NCS (2.67 g, 20.0 mmol). This mixture was allowed to warm to room temperature and stirred for 24 h, and then poured into 300 mL ice-water and extracted with ethyl acetate. The extracts were washed with 1 M NaOH and brine, dried and evaporated. The residue was purified by column chromatography on silica gel to give 4,5-dichloropyridin-2-amine (1.12 g, 69.0%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-80-2, 4-Chloropyridin-2-amine.

Reference:
Article; Xie, Dongsheng; Lu, Jun; Xie, Jin; Cui, Junjun; Li, Teng-Fei; Wang, Yan-Chao; Chen, Yuan; Gong, Nian; Li, Xin-Yan; Fu, Lei; Wang, Yong-Xiang; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 19 – 32;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In an article, author is Gu, Shengshen, once mentioned the application of 19798-80-2, Name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, molecular weight is 128.56, MDL number is MFCD04113820, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Name: 4-Chloropyridin-2-amine.

Cobalt porphyrin immobilized on the TiO2 nanotube electrode for CO2 electroreduction in aqueous solution

Herein we report CO2 electrochemical reduction reaction (CO2 ERR) on the cobalt tetraphenylporphyrin (CoTPP) modified TiO2 nanotube (TNT) electrode. It was found the axial coordination of drop-casting solvent to CoTPP and the porphyrin structure are the major factors that have significant effects on the catalytic performance of the electrode. As confirmed by spectrophotometric titration, pyridine has a stronger coordination bond to CoTPP than DMF and THE thus leading to the highest efficiency among the dropcasting solvents tested in the study. Based on the spectrophotometric analysis, possible coordination mechanism between drop-casting solvents and CoTPP is put forward. On the other hand, introduction of -COOMe substituents in phenyl rings of CoTPP weakens the coordination bond between pyridine and CoTPP as clearly evidenced by deuterium NMR spectra, resulting in a detrimental effect on CO2 ERR. Therefore, the manipulation of the coordination environment around the metal center of immobilized catalyst is crucial in designing an efficient electrocatalytic system. (C) 2020 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by ELSEVIER B.V. and Science Press. All rights reserved.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Chen, Hong, once mentioned the application of 19798-80-2, Name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, molecular weight is 128.56, MDL number is MFCD04113820, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 4-Chloropyridin-2-amine.

Rhenium(I) N-Heterocyclic Carbene Complexes in Photoinitiating Systems for Polymerization upon Visible Light: Development of Photosensitive Resins for 3D and 4D Applications

Two fac-rhenium tris-carbonyl complexes bearing a pi-accepting pyridoannelated N-heterocyclic carbene (NHC) ligand with general formula Re(CO)(3) (pyipy)X, where pyipy is 2-pyridil-imidazo[1,5-a]pyridine-3-ylidene and X = CI (Re1) and Br (Re2), are investigated as photoredox catalytic systems in light-promoted polymerization reactions. Both rhenium(I) complexes are able to efficiently generate radicals to initiate free radical polymerization. Remarkably, excellent radical polymerization profiles and final conversions are obtained under soft irradiations (LED lamp, lambda(exc) = 405 nm) by using the proposed complexes with iodonium salt and amine as photoinitiating systems (PISs) for polyethyleneglycol (PEG)-acrylate monomers. The involved mechanism is investigated by means of different spectroscopic techniques and further supported by electrochemical data. In addition, using the prepared three-component PISs, outstanding 3D patterns with spatial resolution could be obtained through direct laser write experiments. Remarkably, the resulting material displays reversible deformation that can be controlled with heating-hydration cycles due to stimuli-responsiveness of PEG chains of the polymeric network, thus opening the way for innovative smart and stimuli-responsive 4D-printed materials and soft actuators.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

19798-80-2, Name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, Product Details of 19798-80-2, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Klemens, Tomasz, once mentioned the new application about 19798-80-2.

Tuning Optical Properties of Re(I) Carbonyl Complexes by Modifying Push-Pull Ligands Structure

In this work, the structure-property relationship was investigated for a series of Re(I) carbonyls [ReCl(CO)(3)(R-terpy-kappa N-2)], [ReCl(CO)(3)(R-dtpy-kappa N-2)], and [ReCl(CO)(3)(R-dppy-kappa N-2)]. The studied compounds bear 2,2′:6′,2 ”-terpyridines (R-terpy), 2,6-di(thiazol-2-yl)pyridines (R-dtpy), and 2,6-di(pyrazin-2-yl)pyridines (R-dppy) functionalized with strongly electron-donating cyclic (piperidine and morpholine) and acyclic (dimethylamine, diphenylamine) amine donor attached to the central pyridine ring of the triimine skeleton via phenylene linkage. Their thermal properties were evaluated using DSC. The ground- and excited-state properties of these systems were elucidated with electrochemistry, absorption and emission spectroscopy, and density-functional theory (DFT)-based calculations. The terpy skeleton was found to efficiently stabilize the LUMO orbital, as manifested by the most negative reduction potentials for Re(I) terpyridine complexes and significant blue-shift of the absorption and emission of [ReCl(CO)(3)(R-terpy-kappa N-2)] in relation to those of Re(I) carbonyls bearing dtpy- and dppy-based ligands. Substitution of the triimines with amine substituents resulted in participation of intraligand charge-transfer (ILCT) transitions, and it was found to be beneficial for hole-transport properties of the Re(I) carbonyls. The constructed nondoped and doped single layer diodes based on Re(I) complexes emitted red light with various intensity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 19798-80-2 help many people in the next few years. Product Details of 19798-80-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem