Category: 19798-81-3

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19798-81-3, name is 6-Bromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To a solution of 6-bromopyridin-2-amine (1 g, 5.78 mmol) in acetonitrile (10 mL) was added N-chlorosuccinimide (0.849 g, 6.36 mmol) and the mixture was heated at 80C for 12 hours. The mixture was filtered through diatomaceous earth and concentrated and the residue was dissolved in ethyl acetate and washed with water and brine. Drying over anhydrous sodium sulfate, filtration, concentration and purification by column chromatography (silica gel, 30% ethyl acetate in hexane) afforded the title compound. LCMS: 209.1 (M+2)+.

With the rapid development of chemical substances, we look forward to future research findings about 19798-81-3.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; TONG, Yunsong; BRUNCKO, Milan; CLARK, Richard F.; CURTIN, Michael L.; FLORJANCIC, Alan S.; FREY, Robin R.; GONG, Jianchun; HANSEN, Todd M.; JI, Zhiqin; LAI, Chunqiu; MASTRACCHIO, Anthony; MICHAELIDES, Michael; MIYASHIRO, Juliem; RISI, Roberto M.; SONG, Xiaohong; TAO, Zhi-fu; WOODS, Keith W.; ZHU, Guidong; PENNING, Thomas; SOUERS, Andrew; GOSWAMI, Rajeev; IQUTURI, Omprakash Reddy; DABBEERU, Madhu Babu; WO2014/139328; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19798-81-3, name is 6-Bromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 6-Bromopyridin-2-amine

Under ice cooling, a solution of 6-bromopyridin-2-amine (10 g, 57.8 mmol) in MeCN (100 mL) was slowly added dropwise to a solution of NBS (10.3 g, 57.8 mmol) in MeCN (200 mL). After dropping, the temperature was maintained for 1 hour. After completion of the reaction, the mixture was concentrated under reduced pressure to 20 mL. 300 mL of EtOAc was added. The organic phase was washed with H2O, saturated NaCl solution, and dried over anhydrous Na2SO4. The solvent was concentrated under reduced pressure to give the product, 14.2 g, 97% yield, as a white solid

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19798-81-3, 6-Bromopyridin-2-amine.

Reference:
Patent; Shenzhen Bolijian Pharmaceutical Co., Ltd.; Huang Liye; Liu Yun; Li Tao; Mao Wenjin; Liu Huabin; (28 pag.)CN107778302; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem