Category: 19828-20-7

Reference of 19828-20-7 , The common heterocyclic compound, 19828-20-7, name is 2-Amino-5-acetylpyridine, molecular formula is C7H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3: N-(5-Acetyl-pyridin-2-yl)-4-(3-dimethylamino-propoxy)-benzenesulfonamide The flask was charged with 1-(6-amino-pyridin-3-yl)-ethanone (100 g, 0.74 mol. Ref: J. Med. Chem. 1973, 16 (8), 959-961) and was purged with nitrogen. To this was added 500 mL pyridine, and the mixture was heated to 60 C.; a pale amber solution was obtained. To it was added 230 g 4-[3-(dimethylamino)propoxy]benzenesulfonyl chloride (230 g, 0.74 mol) in portions over the course of one hour. After the addition was complete the mixture was heated to 60 C. for 90 minutes. It was allowed to cool to 35 C., and was then poured into a vigorously stirred mixture of 2L ethyl acetate and 1170 g dibasic potassium phosphate dissolved in 2 L water. The mixture was stirred for 15 minutes. The resulting precipitate was collected by filtration. It was washed with 2*1 L ethyl acetate and air dried to give 330 g of crude tan solid. 1H-NMR (400 MHz, DMSO) delta 8.60 (s, 1H), 7.96 (d, 1H), 7.77 (d, 2H), 6.95-7.00 (m, 3H), 4.02 (t, 2H), 2.60 (t, 2H), 2.42 (s, 3H), 2.33 (s, 6H), 1.84-1.96 (m, 2H); [M+H]+378.

The synthetic route of 19828-20-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KALYPSYS, INC.; US2007/135438; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19828-20-7, name is 2-Amino-5-acetylpyridine, molecular formula is C7H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-Amino-5-acetylpyridine

Step A: 2-(6-Aminopyridin-3-yl)-6-chloroquinoline-4-carboxylic acid (27) [00392] A solution of l-(6-aminopyridin-3-yl)ethanone 16, example 8, step A) (1.5 g, 11.0 mmol) in ethanol (10 mL) was added slowly to a solution of 5-chloroindoline-2,3-dione (9) (1.66 g, 9.17mmol) in 6M aqueous KOH (lOmL) at 100C. The reaction was monitored by LCMS until the staring material consumed. Then the reaction mixture was concentrated to remove ethanol, the residue was diluted with water (10 mL), the pH value of the mixture was acidified to 5 by adding 1M aqueous HCl solution. The precipitate was filtered to give the desired product (1.2 g, 44%) as an orange solid. LC-MS: (M + H)+ 300.1

With the rapid development of chemical substances, we look forward to future research findings about 19828-20-7.

Reference:
Patent; NEW YORK UNIVERSITY; UNIVERSITY OF ALBANY; SCHMIDT, Ann, Marie; RAMASAMY, Ravichandran; SHEKHTMAN, Alexander; RAI, Vivek; MANIGRASSO, Michaele, B.; (179 pag.)WO2017/184547; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem