Category: 1990-90-5

Application of 1990-90-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The crude 2-(5-chloro-2-fluorophenyl)-4-iodo-5,6,7,8-tetrahydroquinazoline (130 mg, 0.35 mmol, 1 eq) was dissolved in dioxane (5 ml) and to this was added Pd(OAc)2 (4 mg, 0.02 mmol, 0.05 eq) followed by BINAP (16 mg, 0.03 mmol, 0.075 eq), 4-amino-3-picoline (49 mg, 0.45 mmol, 1.3 eq) and Cs2CO3 (170 mg, 0.52 mmol,1.5 eq). The reaction mixture was heated to 80C for 15 h. The reaction mixture was cooled to r.t. and filtered through Celite and the crude material was purified by flash column chromatography (l:l/ethyl acetate:hexane) to afford [2-(5-chloro-2-fluoro- EPO phenyl)-5,6,7,8-tetrahydroquinazolin-4-yl]-(3-methylpyridin-4-yl)-amine, compound of formula (38) (110 mg, 86%)

According to the analysis of related databases, 1990-90-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2006/35061; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1990-90-5, name is 3-Methylpyridin-4-amine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H8N2

To a solution of 2-(5-chloro-2-fluorophenyl)-4-iodo-5-methyl-6,7-dihydro-5H-cyclo- pentapyrimidine (275 mg, 0.71 mmol, 1 eq) in dioxane (5 ml) was added Pd(OAc)2 (8 mg, 0.04 mmol, 0.05 eq) followed by BINAP (33 mg, 0.05 mmol, 0.075 eq), 4-amino-3-picoline (84 mg, 0.78 mmol, 1.1 eq) and Cs2CO3 (347 mg, 1.06 mmol, 1.5 eq). The reaction mixture was heated to 80C for 15 h. The reaction mixture was cooled to r.t. and filtered through Celite and the crude material was purified by flash column chromatography (l:l/ethyl acetate:hexane-100% ethyl acetate) to afford [2-(5-chloro-2-fluorophenyl)-5-methyl-6,7-dihydro-5H-cyclopentapyrimidin-4-yl]- (3-methyl-pyridin-4-yl)-amine, compound of formula (43) (250 mg, 96%)

The synthetic route of 1990-90-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2006/35061; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1990-90-5 , The common heterocyclic compound, 1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A total of 20.628 mg (0.1 mmol) of S-IBU and 10.814mg (0.1 mmol) of 3M4AP were dissolved in methanol-H2O (3:1, v: v) and left for slow evaporation at ambient conditions. Good quality single crystals were obtained for SCXRD after 10 days

The synthetic route of 1990-90-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ma, Dejia; Pei, Tiezhu; Bai, Yunhe; Zhou, Lina; Bao, Ying; Yin, Qiuxiang; Xie, Chuang; Journal of Molecular Structure; vol. 1179; (2019); p. 487 – 494;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1990-90-5 , The common heterocyclic compound, 1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A total of 20.628 mg (0.1 mmol) of S-IBU and 10.814mg (0.1 mmol) of 3M4AP were dissolved in methanol-H2O (3:1, v: v) and left for slow evaporation at ambient conditions. Good quality single crystals were obtained for SCXRD after 10 days

The synthetic route of 1990-90-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ma, Dejia; Pei, Tiezhu; Bai, Yunhe; Zhou, Lina; Bao, Ying; Yin, Qiuxiang; Xie, Chuang; Journal of Molecular Structure; vol. 1179; (2019); p. 487 – 494;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1990-90-5, Adding some certain compound to certain chemical reactions, such as: 1990-90-5, name is 3-Methylpyridin-4-amine,molecular formula is C6H8N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1990-90-5.

To a solution of 2-(5-chloro-2-fluorophenyl)-4-iodo-5,7-dihydrofuro[3,4-d]pyrimidine (80 mg, 0.21 mmol, 1 eq) in anhydrous dioxane (5 ml) was added Pd(OAc)2 (2 mg, 0.01 mmol, 0.05 eq) followed by BINAP (10 mg, 0.02 mmol, 0.075 eq), 4-amino-3- picoline (25 mg, 0.23 mmol, 1.2 eq) and Cs2CO3 (100 mg, 0.32 mmol, 1.5 eq). The EPO reaction mixture was heated to 80C for 15h. The reaction mixture was cooled to r.t. and filtered through Celite and the crude material was purified by flash column chromatography (9:l/ethyl acetate:hexane) to afford [2-(5-Chloro-2-fluorophenyl)-5,7- dihydrofuro[3,4-d]pyrimidin-4-yl]-(3-methyl-pyridin-4-yl)-amine, compound of formula (33) (20 mg, 26%) as a white solid

According to the analysis of related databases, 1990-90-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2006/35061; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1990-90-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, molecular weight is 108.14, as common compound, the synthetic route is as follows.

To a solution of 3-methylpyridin-4-amine (10 g, 92.6 mmol) in THF (100 ml.) was added TEA (14 g, 138 mmol) and DMAP (1 .12 g, 9.25 mmol) followed by addition of (Boc)20 (22.2 g, 101 mmol) at 0 C. The reaction mixture was stirred at rt for 16h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was concentrated under vacuum. The residue was diluted with water (50 ml.) and extracted with DCM (3 x 70 ml_). The organic layer was separated, dried over anhydrous Na2S04 and concentrated under vacuum to afford 16.2 g of tert-butyl A/-(3-methylpyridin-4-yl)carbamate a49, which was used in next step without further purification. LCMS (ES+): 209 (M+H)+, 96% purity. 1H NMR (400 MHz, DMSO-cfe) delta 8.76 (s, 1 H), 8.22-8.26 (m, 2H), 7.62-7.66 (m, 1 H), 2.18 (s, 3H), 1 .48 (s, 9H).

The chemical industry reduces the impact on the environment during synthesis 1990-90-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UCB BIOPHARMA SPRL; ATES, Ali; JNOFF, Eric; PROVINS, Laurent; VALADE, Anne; HALL, Adrian; (97 pag.)WO2017/178377; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1990-90-5, name is 3-Methylpyridin-4-amine. A new synthetic method of this compound is introduced below., Safety of 3-Methylpyridin-4-amine

To a solution of intermediate 2c (100 mg) in CH2Cl2(7 mL) were consecutively added N,N-Diisopropylethylamine (140 muL), 3-methylpyridin-4-amine (40 mg) and bromotripyrrolidinophosphonium hexafluorophosphate (230 mg) and the mixture was stirred at ambient temperature for 2 h. The volatiles were removed under reduced pressure and the residue was purified by column chromatography (Interchim cartridge50SiHP/25 g, Cy/EtOAc) to yield the desired compound (84% yield). [0430] LC-MS (Method 2): m/z [M+H]+=353.2 (MW calc.=352.39); Rt=0.48 min

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1990-90-5, 3-Methylpyridin-4-amine.

Reference:
Patent; Gruenenthal GmbH; Nordhoff, Sonja; Wachten, Sebastian; Kless, Achim; Voss, Felix; Ritter, Stefanie; US2014/194452; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1990-90-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of the imino chloride [(500MG,] 1. [42MMOL)] in dioxane [(5ML)] was added Pd2 (dba) 3 (65mg, 0. [07MMOL)] followed by BINAP (66mg, [0.] [1] [LMMOL),] 4-amino-3-picoline (230mg, 2. [13MMOL)] and NaO’Bu (273mg, 2. [84MMOL).] The reaction mixture was heated to [90C] for 15h. The reaction mixture was cooled to r. t. and filtered through Celite and the crude 219002029440 material purified by flash column chromatography to give (152 mg, 24% yield) as a cream colored solid. ESMS: 440 [(M+).]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1990-90-5, 3-Methylpyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SCIOS INC.; WO2004/24159; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1990-90-5 , The common heterocyclic compound, 1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-(5-Chloro-2-fluoro-phenyl)-4-iodo-6,6-dimethyl-6,7-dihydro-5H- cyclopentapyrimidine (100 mg, 0.25 mmol), 3-Methyl-pyridin-4-ylamine (30 mg,0.27 mmol), Pd(OAc)2 (3 mg, 12.42 mumol) and itoc-BINAP (12 mg, 18.63 mumol) in dry dioxane (3 mL) was added Cs2CO3 (121 mg, 0.37 mmol). The mixture was heated for 48 h at 85C, cooled and evaporated. HPLC purification gave, after lyophilization, the desired product of formula (60) as the TFA salt, which was a white solid (6.4 mg)

The synthetic route of 1990-90-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2006/35061; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1990-90-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: tert-butyl (3-methylpyridin-4-yl)carbamate (6B) To a solution of 3-methylpyridin-4-amine (6A) (38.0 g, 0.35 mol) in 1-butanol (300 mL) was added (Boc)2O (84.3 g, 0.38 mol). The mixture solution was stirred at r.t. for 8 hours. Then the solution mixture was diluted with EA (1000 mL), washed with water (2*500 mL) and brine (1*250 mL), dried with Na2SO4 and concentrated. The crude product was purified by flash chromatography to afford the title compound 6B (73.0 g, 99%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1990-90-5, 3-Methylpyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Fronthera U.S. Pharmaceuticals LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; LI, Yao; (169 pag.)US2019/367515; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem