Category: 1991/2/1

Singh, Anmol published the artcileComparative study of palladium(II) complexes bearing tridentate ONS and NNS Schiff base ligands: Synthesis, characterization, DFT calculation, DNA binding, bioactivities, catalytic activity, and molecular docking, Application In Synthesis of 91-02-1, the publication is Polyhedron (2022), 115895, database is CAplus.

Two palladium (II) Schiff base complexes were prepared by using equivalent molar of Schiff base ligand [L¹ = (E)-2-(((2-(benzylthio)phenyl)imino)methyl)naphthalen-1-ol and L² = (E)-N-(2-(benzylthio)phenyl)-1-phenyl-1-(pyridin-2-yl)methanimine] and sodium tetrachloropalladate. The structure of ligands and complexes were characterized by physicochem. and spectroscopic analyses. The results suggested that the Pd(II) complexes have a distorted square planar geometry when coordinated to the tridentate ONS from L¹ and the NNS donor ligand from L². Electronic absorption and spectrofluorometric measurements were employed to investigate the DNA binding of ligands and their associated complexes with CT-DNA. DFT calculations were used to optimize the geometric structures and calculate the electronic and structural properties of the synthesized compounds NBO anal. was also performed in combination with the TD-DFT method. Moreover, to study the reactivity and bioactivity, the synthesized compounds were tested for in-vitro antioxidant activity by utilizing the DPPH method, in-vitro anti-inflammatory activity using protein denaturation method, and in-vitro anti-diabetic activity employing α-glucosidase and α-amylase enzymes. The results reflect that PdL¹ is more biol. potent than PdL² or other related palladium complexes, as discussed in the literature. The binding mechanism of the synthesized compounds with CT-DNA, α-glucosidase, and α-amylase, was investigated using mol. docking experiments In addition to these, the catalytic activity of palladium metal complexes (PdL¹ and PdL²) was evaluated for the Suzuki-Miyaura reaction for comparisons.

Polyhedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C13H16BF3O2S, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Singh, Yogendra Pratap published the artcileMolecular structures, spectral, electrochemical, DFT and antioxidant activities of copper(II) complexes with NNO donor Schiff base ligand, Application In Synthesis of 91-02-1, the publication is Journal of Molecular Structure (2021), 129457, database is CAplus.

The synthesis and solid state structural, spectral and electrochem. solution characterization of [Cu(L)(acpy)]ClO₄ 1 and [Cu(L)(NO₃)] 2 [where L = N’-[(E)-phenyl(pyridin-2-yl)methylidene]thiophene-2-carbohydrazide and acpy = 2,6-Diacetylpyridine] were done by elemental anal., UV-visible, FTIR, electrochem. techniques (CV and DPV) and EPR spectroscopy. The single crystal structures were solved by the x-ray diffraction technique. In complex 1, copper ion is in a distorted octahedral environment. The geometry of copper(II) in complex 2 is distorted square pyramidal (τ = 0.201). The mono deprotonated, HL ligand act as a tridentate to a copper(II) ion. On the basis of d. functional theory (DFT) calculation, the electronic excitations involve transitions mainly from metal ligand bonding mostly the α-LUMO within the dominant Cu d_xy character and to α-LUMO+1. EPR spectra for polycrystalline samples showed the copper(II) hyperfine features as well as half-field signal which are appropriate for ΔM_s = ±2 of dimers. Presence of half-field signal in 1 is due to solid-solid interaction (intra-mol.) where as in 2 the nature of interaction is intra-mol. The antioxidant superoxide measurements show that the both complexes 1 and 2 behave as superoxide mimic in alk. nitro blue tetrazolium chloride assay.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Singh, Y. published the artcileNon-covalent interactions governing the supramolecular assembly of copper(II) complexes with hydrazone-type ligand: Experimental and quantum chemical study, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Polyhedron (2021), 115142, database is CAplus.

Two new mono- and one binuclear μ-nitrato bridged Cu(II) complexes [Cu(L)(HL)]ClO₄ (1), [Cu(HL)(NO₃)(H₂O)]2NO₃•H₂O (2) and [Cu₂(L₂)(μ-NO₃)₂] (3), with an unsym. NNO donor Schiff base (HL) were synthesized and characterized by elemental anal., FTIR, CV, UV-visible and EPR spectroscopy. Their mol. structures were also determined by single crystal x-ray crystallog. In the binuclear complex 3, the Cu··· Cu distance is 3.494 Å. In 1, 2 and 3, the Cu(II) centers have distorted square pyramidal geometry (τ₅ = 0.05-0.17). Evidence of weak π···π stacking intermol. interactions along with other noncovalent interactions (H bonding) was observed by analyzing the resp. crystal structures of the complexes. Thus, these H bonds, π···π stacking interactions and other weak intermol. interactions establish as supramol. architectures a crystalline network environment. The noncovalent interactions were also studied by employing Hirshfeld Anal. The room temperature magnetic moments of the mononuclear complexes are less than the spin only values which are indicative of small interactions. Also, significant magnetic interactions were not exhibited by binuclear Cu(II) complex 3 in the variable temperature magnetic measurements. The X-band EPR spectra of all three complexes exhibit Cu(II) hyperfine structures as well as zero-field splitting which are appropriate for the triplet states of dimers. In 1 and 2, the presence of pseudo dipolar interactions is proposed. Quantum chem. calculations (DFT) were carried out on complexes 1–3 to explore the electronic and spectral properties of these newly synthesized complexes. These complexes show significant antiproliferative and SOD activity. The SOD activity measured in terms of k_McCF is in the range 4.94-12.31 (mol L)^-1s^-1 x 10⁴.

Polyhedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C9H10O3S, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhao, Bin published the artcileElectrochemical fluorosulfonylation of alkenes to access vicinal fluorinated sulfones derivatives, Quality Control of 91-02-1, the publication is Tetrahedron (2022), 132651, database is CAplus.

Herein, a practical and efficient fluorosulfonylation of the various alkenes with sulfonyl radical sources and Et₃N·3HF as cost-effective fluorination reagents under mild conditions is reported. Remarkably, this protocol features very green and sustainable conditions obviating the need of chem. oxidants and transition metal catalyst. A variety of substituents on both sulfonyl hydrazides and alkenes are tolerated to give vicinal fluorinated sulfones in moderate to excellent yields. Also, the synthetic utility of this transformation is further demonstrated by a gram-scale reaction and the late-stage functionalization of complex mols.

Tetrahedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C20H17FO4S, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Xiaoqing published the artcileInfluence of Guest/Host Morphology on Room Temperature Phosphorescence Properties of Pure Organic Doped Systems, Name: Phenyl(pyridin-2-yl)methanone, the publication is Journal of Physical Chemistry Letters (2021), 12(30), 7357-7364, database is CAplus and MEDLINE.

Guest/host phosphorescence materials have attracted much attention; traditionally, researchers have focused on the influence of the electronic properties and energy levels of the mols. on the phosphorescence activities. The effects of the morphol. on the phosphorescence are ignored. Three isoquinoline guests with different aliphatic rings and 3 hosts are selected to construct guest/host materials. The guests are dispersed in the host as clusters. The morphols. of the guest/host directly affect the phosphorescence. In these systems, the guests have strong intermol. interactions, which are beneficial to stabilize the triplet excitons; meanwhile, the hosts should have weak intermol. interactions with easily changed morphol. to accept the guest clusters, which synergistically ensure that the doped materials have excellent RTP properties. This is the 1st work focusing on the effect of mol. morphol. on the phosphorescence of guest/host systems.

Journal of Physical Chemistry Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kim, Jong Hyun published the artcileAnticancer gold(III)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition, Application In Synthesis of 91-02-1, the publication is Chemical Science (2021), 12(21), 7467-7479, database is CAplus and MEDLINE.

Expanding the chem. diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chem. of gold to create organometallic gold(III) compounds by ligand tuning. We obtained novel organogold(III) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiol. stability. Biol. evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of ATP (ATP). Mechanism-of-action efforts, RNA-Seq, quant. proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple neg. breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiol.

Chemical Science published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hamukwaya, Eunike published the artcileA multi-colorimetric probe to discriminate between heavy metal cations and anions in DMSO-H₂O with high selectivity for Cu²⁺ and CN^–: study of logic functions and its application in real samples, Quality Control of 91-02-1, the publication is RSC Advances (2021), 11(47), 29466-29485, database is CAplus and MEDLINE.

A ditopic multi-colorimetric probe based on the phenylpridyl-thioic moiety (EN) was synthesized via a Schiff base reaction mechanism and characterized using ¹H NMR and UV-vis spectroscopy. The colorimetric analyses carried out revealed that EN was capable of discriminating between a number of heavy metal cations via coordination induced charge transfer, as well as between anions through hydrogen bonding induced charge transfer, in DMSO-H₂O (9 : 1). In particular, the ditopic probe could spectrally and colorimetrically recognize the most toxic heavy metal cations of Cd²⁺, Pb²⁺ and Hg²⁺, among others, in DMSO-H₂O. Addnl., EN was selective and sensitive to the presence of CN^–, F^–, AcO^– and H₂PO₄^– in the same solvent system as cations. The reversibility and reproducibility studies showed that EN exhibited complementary IMP/INH logic functions, based on color and spectral switching (ON/OFF), modulated by F^–/Al³⁺. The real time application of the probe was tested on food grade products to detect the presence of F^– in toothpastes and mouthwash dissolved in water, as well as cations in underground water (normally saline), which displayed substantial responses. Thus, EN displayed an excellent scope of response and can thus be developed for real time sensing kits, which could be used instantly in on-field anal. Theor. studies were conducted to complement the exptl. work.

RSC Advances published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Palav, Amey published the artcileRapid, chemoselective and mild oxidation protocol for alcohols and ethers with recyclable N-chloro-N-(phenylsulfonyl)benzenesulfonamide, Synthetic Route of 91-02-1, the publication is Tetrahedron Letters (2021), 153094, database is CAplus.

A sulfonimide reagent, N-chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI) was identified as a mild and selective oxidant. Without activation, the reagent was proved to oxidize primary and secondary alcs. as well as their sym. and mixed ethers to corresponding aldehydes and ketones. With recoverable PS-TEMPO catalyst, selective oxidation over chlorination of primary and secondary alcs. and their ethers with electron-donating substituents was achieved. The reagent precursor of NCBSI was recovered quant. and can be reused for synthesizing NCBSI.

Tetrahedron Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nevskaya, Alisa A. published the artcileSynthesis and cytotoxicity of novel 1-arylindolizines and 1-arylpyrrolo[2,1-a]isoquinolines, Product Details of C12H9NO, the publication is Tetrahedron Letters (2021), 153552, database is CAplus.

An efficient approach to the synthesis of indolizines and pyrrolo[2,1-a]isoquinolines based on a domino reaction was described. The reactivity of the derivatives and the structure-activity anal. are carried out in a number of the obtained compounds A hit was found showing high cytotoxicity on tumor cells whose cytotoxic effect was comparable to that of the known topoisomerase I inhibitor camptothecin.

Tetrahedron Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zeng, Kui published the artcileDirect nitrogen interception from chitin/chitosan for imidazo[1,5-a]pyridines, Name: Phenyl(pyridin-2-yl)methanone, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(41), 6068-6071, database is CAplus and MEDLINE.

A catalyst-free one-pot methodol. that enable direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed. This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands. In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines were unprecedentedly synthesized by this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C15H24S, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem