Category: 1991/2/1

Mangalam, Neema Ani published the artcileDiversities in the chelation of aroylhydrazones towards cobalt(II) salts: Synthesis, spectral characterization, crystal structure and some theoretical studies, COA of Formula: C12H9NO, the publication is Journal of Molecular Structure (2021), 129978, database is CAplus.

Five Co complexes synthesized from two aroylhydrazones were characterized by elemental analyses, TGA, molar conductivity, magnetic susceptibility measurements, IR and electronic spectra. Single crystal x-ray structure of one of the complex is also reported and it got crystallized in triclinic space group P1̅ and the crystal structure shows a distorted octahedral geometry around the metal center. Spectral data reveal that both the aroylhydrazones are tridentate and coordinate through the azomethine N, hydrazonic O, and pyridyl N. Magnetic susceptibility measurements confirm the paramagnetic nature of the Co(II) complexes and one of the complex is diamagnetic in nature. Addnl., HF/6-311G(d,p)/LANL2DZ calculations were performed to predict the possible intramol. interactions contributing to the lowering of the stabilization energy. Accordingly, πâ†?π^* transitions are responsible for the stabilization energy for the ligands and their Co complexes. To describe and discuss the chem. reactivity and stability of synthesized complexes, quantum chem. parameters like frontier orbital energies, hardness, softness, energy gap, electronegativity, chem. potential, electrophilicity, polarizability and dipole moment were calculated Also, the main electronic structure principles such as maximum hardness, min. polarizability, and min. electrophilicity principles were considered to evaluate the stability of the complexes.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Raghu, M. S. published the artcileSynthesis, characterization, antimicrobial and interaction studies of pteridines with human serum albumin: A combined multi-spectroscopic and computational study, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Molecular Structure (2022), 1250(Part_3), 131857, database is CAplus.

A novel series of pteridine derivatives I [R = H, F, Cl, F₃C, Br] was synthesized, and the structures of these mols. were established using elemental anal. and numerous spectroscopic methods. The disk diffusion technique was used to examine the antimicrobial potential of the newly synthesized mols. Among the compounds examined, I [R = F, F₃C] compounds had the highest impact against the examined bacterial and fungal strains. The compounds min. inhibitory concentration (MIC) was observed to be in the line of 0.41-6.83μM. UV-vis absorption, fluorescence quenching, FT-IR spectroscopy and CD (CD) along with mol. docking methods, were studies to assess the binding behavior of efficient pteridine derivatives I [R = F, F₃C] with human serum albumin (HSA). Formation of HSA-test compounds complex indicated the static quenching phenomena during fluorescence quenching of HSA by test compounds Synthesized I [R = F, F₃C] were further evaluated for three basic binding sites of HSA including subdomains IIA, IIIA, and IB, using mol. docking studies. Hydrophobic and interaction through hydrogen bonding influenced the binding pathway of HSA with test mols., according to the mol. docking data. Furthermore, the DFT technique was used to optimize the mol. geometry of potent I [R = F, F₃C] compounds using the B3LYP hybrid functional and the 6-311 + G(d, p) basis set. The optimized structure closely aligned with the test findings. The electrostatic potential framework was produced to visualize the mol.’s energy distribution and chem. reactive areas.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guha, Somraj published the artcileIodine-promoted controlled and selective oxidation of (aryl)(heteroaryl)methanes, Category: pyridine-derivatives, the publication is Journal of Organic Chemistry (2022), 87(8), 5424-5429, database is CAplus and MEDLINE.

Herein, an iodine-catalyzed controlled oxidation of (aryl)(heteroaryl)methanes to (aryl)(heteroaryl)methanols ArCH(O)Ar¹ [Ar = Ph, 2-MeC₆H₄, 4-ClC₆H₄, etc.; Ar¹ = pyridin-2-yl, benzothiazol-2-yl] was disclosed under metal-free reaction conditions. A catalytic system comprised of iodine/silyl chloride with HI as an additive in the presence of DMSO selectively oxidize the C(sp³)-H bonds without being over oxidized to corresponding ketones. Therapeutically important aryl heteroaryl methanol derivatives were obtained in good yields. The preliminary mechanistic investigation proved that the primary source of oxygen was DMSO.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chatterjee, Arnab published the artcilepH dependent catecholase activity of Fe(II) complexes of type [Fe(L)]X₂ [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO^–₄ (1), PF^–₆ (2)]: Role of counter anion on turnover number, SDS of cas: 91-02-1, the publication is Inorganica Chimica Acta (2020), 119933, database is CAplus.

Two mononuclear Fe(II) complexes having same ligand framework, coordination geometry but different counter anions [Fe(L)]X₂ [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO^–₄ (1), PF^–₆ (2)] have been synthesized and crystallog. characterized. Both the complexes catalyzed catechol-quinone oxidation pH dependently. In the pH range 8.3-8.5 the suitable activity of both the complexes were found. Counter anions in the complexes played a significant role in controlling the turn over numbers of the catalytic reactions. In acetonitrile (MeCN), the turn over number for 1 was 4.99 h^-1 and for 2, it was 42.75 h^-1.

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, SDS of cas: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Baydas, Yasemin published the artcileAsymmetric reduction of aromatic heterocyclic ketones with bio-based catalyst Lactobacillus kefiri P2, Related Products of pyridine-derivatives, the publication is Chemical Papers (2021), 75(3), 1147-1155, database is CAplus.

In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asym. reduction of prochiral ketones RC(O)R¹ (R = pyridin-2-yl, 2H-1,3-benzodioxol-5-yl, furan-2-yl, etc.; R¹ = Me, Ph, pyridin-2-yl) to chiral secondary alcs R/S-RCH(R¹)OH. Secondary chiral carbinols were obtained by asym. bioreduction of different prochiral substrates with results up to > 99% enantiomeric excess (ee). The compound R/S-RCH(R¹)OH (R = pyridin-2-yl, R¹ = Me (I)) which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective β-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70 g of I in enantiomerically pure form was obtained in 96% yield. Also, production of I in terms of yield and gram scale through catalytic asym. reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcs. compared to chem. processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis.

Chemical Papers published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gou, Yi published the artcileDithiocarbazate-Fe^III, -Co^III, -Ni^II, and -Zn^II Complexes: Design, Synthesis, Structure, and Anticancer Evaluation, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Medicinal Chemistry (2022), 65(9), 6677-6689, database is CAplus and MEDLINE.

Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [Fe^III(L)₂]·Cl·2H₂O 1, [Co^III(L)₂]·NO₃·2.5H₂O 2, [Ni^II(L)₂] 3, and [Zn^II(L)₂] 4, have been designed and evaluated for their efficacy as antineoplastic agents. Among them, complex 2 exhibited higher anticancer efficacy than complexes 1, 3, 4, and cisplatin against several cancer cell lines. Hemolysis assays revealed that complex 2 showed comparable hemolysis with cisplatin. In vivo anticancer evaluations showed that complex 2 could retard tumor xenograft growth effectively with low systemic toxicity. Further studies revealed that complex 2 suppressed cancer cells by triggering multiple mechanisms involving the simultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancer mechanism of Co complexes, which can be used as a good strategy to overcome the flexibility of cancer cells to chemotherapy adaptation.

Journal of Medicinal Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Song, Peidong published the artcileDevelopment of a Tunable Chiral Pyridine Ligand Unit for Enantioselective Iridium-Catalyzed C-H Borylation, Related Products of pyridine-derivatives, the publication is ACS Catalysis (2021), 11(12), 7339-7349, database is CAplus.

Although pyridine derivatives are versatile supporting ligands in catalysis, the development of their chiral versions has been relatively limited. Herein, we report the design, synthesis, and proof-of-concept application of a structurally tunable chiral pyridine framework featuring an annulated compact ring system. Using an N,B-bidentate ligand skeleton containing the chiral pyridine moiety, we have developed an enantioselective iridium-catalyzed desymmetrizing C-H borylation reaction of diaryl(2-pyridyl)methane compounds with up to 96% ee and 93% yield. The resulting borylation products could be readily transformed into various chiral tri(hetero)arylmethane compounds D. functional theory investigations revealed that the two chair conformations of the flexible ketal motif both favored the enantiomer that was consistent with exptl. results. This work has thus introduced an effective and tunable chiral pyridine ligand framework that may be used in many catalytic asym. transformations.

ACS Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C9H5ClO2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kondoh, Azusa published the artcileFormal umpolung addition of phosphites to 2-azaaryl Ketones under chiral Broensted base catalysis: enantioselective protonation utilizing [1,2]-phospha-Brook rearrangement, HPLC of Formula: 91-02-1, the publication is Chemistry – A European Journal (2022), 28(42), e202201240, database is CAplus and MEDLINE.

The formal enantioselective umpolung addition of dialkyl phosphites to 2-azaaryl ketones was developed under Broensted base catalysis. The reaction involved the enantioselective protonation of the transient α-oxygenated (2-azaaryl)methyl anion generated through the 1,2-addition of the anion of dialkyl phosphite to the 2-azaaryl ketone and the subsequent [1,2]-phospha-Brook rearrangement. A chiral bis(guanidino)iminophosphorane organosuperbase efficiently catalyzed the reaction to provide enantio-enriched phosphates in high yields with good to high enantioselectivities. This is a rare example of the catalytic enantioselective protonation of transient carbanions other than enolates, constructing a trisubstituted stereogenic center α to 2-azaarenes.

Chemistry – A European Journal published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, HPLC of Formula: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Murayama, Hiroaki published the artcileIridium-Catalyzed Enantioselective Transfer Hydrogenation of Ketones Controlled by Alcohol Hydrogen-Bonding and sp³-C-H Noncovalent Interactions, Application of Phenyl(pyridin-2-yl)methanone, the publication is Advanced Synthesis & Catalysis (2020), 362(21), 4655-4661, database is CAplus.

Iridium-catalyzed enantioselective transfer hydrogenation of ketones with formic acid was developed using a prolinol-phosphine chiral ligand. Cooperative action of the iridium atom and the ligand through alc.-alkoxide interconversion was crucial to facilitate the transfer hydrogenation. Various ketones including alkyl aryl ketones, ketoesters, and an aryl heteroaryl ketone were competent substrates. An attractive feature of this catalysis was efficient discrimination between the alkyl and aryl substituents of the ketones, promoting hydrogenation with the identical sense of enantioselection regardless of steric demand of the alkyl substituent and thus resulting in a rare case of highly enantioselective transfer hydrogenation of tert-alkyl aryl ketones. Quantum chem. calculations revealed that the sp³-C-H/π interaction between an sp³-C-H bond of the prolinol-phosphine ligand and the aryl substituent of the ketone was crucial for the enantioselection in combination with O-H···O/sp³-C-H···O two-point hydrogen-bonding between the chiral ligand and carbonyl group.

Advanced Synthesis & Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Application of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cappello, Daniela published the artcileDual Emission, Aggregation, and Redox Properties of Boron Difluoride Hydrazones Functionalized with Triphenylamines, HPLC of Formula: 91-02-1, the publication is ChemPhotoChem, database is CAplus.

π-Conjugated mol. materials often exhibit interesting photoluminescence, redox, and optoelectronic properties that grant them utility as light-harvesting materials in solar cells, as the emissive component of organic light-emitting diodes, and as fluorescence sensors. Preparing dye conjugates by appending multiple dyes together to generate π-conjugated mols. is a common strategy to enhance the properties of these materials as it often imparts traits that cannot be achieved by the building blocks independently. Herein, we report mol. materials that incorporate boron difluoride hydrazone (BODIHY) and triphenylamine (TPA) units that exhibit charge-transfer character, dual-emission, and aggregation-induced emission. The title compounds have low-energy absorption bands (λ_abs=455-493 nm) that are red-shifted relative to BODIHYs with smaller π-systems and exhibit dual-emission in the solution, solid, and aggregate states. TPA-BODIHY (donor-acceptor) conjugates show multiple reversible redox events and, in combination, the data presented herein indicate that there is electronic communication throughout the donor-acceptor and acceptor-donor-acceptor π-systems. These results are rationalized with the use of computational chem. and solid-state structural anal. This study provides new opportunities for the design of mol. materials that are comprised of redox-active photoluminescent dyes, including BODIHY, and their potential applications.

ChemPhotoChem published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, HPLC of Formula: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem